DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and atp4a

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_031762229.1	Gene:	atp4a / 100488221	XenbaseID:	XB-GENE-486104	Length:	1031	Species:	Xenopus tropicalis

Alignment Length:	1034	Identity:	635/1034 - (61%)
Similarity:	794/1034 - (76%)	Gaps:	6/1034 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKK-ENLDDLKQELDIDFHKISPEELYQRF 73
            |:.:.|.:..|    :..|..||....:.|..:|.:|| |.|:.:|:|:||:.|:|:.|||.|::
Frog     2 GKKEQYDMYAV----EMEREEDGGMDVKIKKKSKGSKKQEKLESMKKEMDINDHEITIEELEQKY 62

  Fly    74 QTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAS 138
            .|:...|:....|.|.|.|||||.|.|||.|||:|||.:.|.||...|:|:.|::|.:|:.|:.:
Frog    63 NTNVTKGMKATFAAEILIRDGPNELKPPKGTPEYVKFARQLAGGLQCLMWVAAVICLIAFGIECA 127

  Fly   139 TSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDL 203
            ..:..:.|||||.|.|.|||:|||.|.||||.||:.|:.||||:|||.|||:|:|||..:.|..|
Frog   128 QGDLTSADNLYLAITLIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVLRDGEKFQINANQL 192

  Fly   204 VLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAV 268
            |:||:||:|.|||:|||||||.::..||||||||||||||:|..|:|||:||||:|:|||||..:
Frog   193 VVGDLVEIKGGDRVPADIRIITSQGCKVDNSSLTGESEPQTRSPEYTHESPLETRNIAFFSTMCL 257

  Fly   269 EGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGY 333
            ||||.||:|:.||.|::||||.||||:...:||||.||.||:.:|.|:|:|.|.||||:|.::||
Frog   258 EGTATGVIINTGDRTIIGRIASLASGVGNEKTPIAIEIEHFVDIIAGLAIFFGATFFVVAMVIGY 322

  Fly   334 HWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGT 398
            .:|.|::|.:.|:||.|||||||||||||:|||||:|.|||:||||||||||||||.||||||||
Frog   323 PFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLARKNCVVKNLEAVETLGSTSVICSDKTGT 387

  Fly   399 LTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKK 463
            ||||||||:|:||||||..|||||||||..:|:||..::|||::.:|||||.||.|||||||.|:
Frog   388 LTQNRMTVSHLWFDNQIHSADTTEDQSGQSFDQTSDTWRALSKVTSLCNRACFKSGQDGVPIPKR 452

  Fly   464 EVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGA 528
            .|.|||||.||||..||.:|:||..|.|.||..|:|||||||:|:||||.:|..|.|||||||||
Frog   453 IVIGDASETALLKFSELTVGNVMEYRDRFKKATELPFNSTNKFQLSIHELQDPLDLRYLLVMKGA 517

  Fly   529 PERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDD 593
            |||||||||||.|.|:|..|||:.||||..|||:||||||||||||...|...:||.||.|:|::
Frog   518 PERILERCSTIMIKGQELPLDEQWKEAFQTAYMDLGGLGERVLGFCHLYLNEKEYPRGFSFDTEE 582

  Fly   594 INFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNET 658
            :|||...|.|.||:||||||||.|||||.|||:|||:||||||||||||||||.||||||||:||
Frog   583 MNFPTSGLCFAGLISMIDPPRATVPDAVMKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSET 647

  Fly   659 VEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGC 723
            |||||.||.|||.:||.|:|:|.|::|.:|:|::|::|.|.|:.|.|:|||||||||||||||.|
Frog   648 VEDIAARLRIPVEQVNKRDARACVINGGQLKDMTSEELVEALKLHPEMVFARTSPQQKLIIVESC 712

  Fly   724 QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 788
            |::||||||||||||||||||||||||||||||||.:|.|||||||||||||||||||:||||||
Frog   713 QKLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFD 777

  Fly   789 NLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRP 853
            |||||||||||.||||::|:|.:|...:|||||.:|||.|:|.||:.|::|||||.||:|||...
Frog   778 NLKKSIAYTLTKNIPELAPYLIYITASVPLPLGCITILFIELCTDIFPSVSLAYERAESDIMHLK 842

  Fly   854 PRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTD 918
            ||:|..|:|||..|...:|.|:|:||:.|||..||.:||:.|:.|..:.|:|..|:::.:.||.|
Frog   843 PRNPRRDRLVNEALAVYSYFQVGIIQSFAGFVDYFTVMAQEGWFPAYVLGLRSHWENQHLQDLED 907

  Fly   919 SYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQG-MRNWALNFGLVFETVL 982
            ||||:||:..|...:|.|:|.|||||.|.|.||::|.||||.|:|||| .||..|...:||:..|
Frog   908 SYGQQWTFSQRLYQQYNCYTVFFISIEVCQIADVLIRKTRRLSVFQQGFFRNKVLVIAIVFQLCL 972

  Fly   983 AAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ..||.|||||.......|::..||...:||.:.||:|||.|:..:|||||.|.::|.||
Frog   973 GNFLCYCPGMPNVFNFMPIRFQWWLVPVPFGILIFVYDEIRKLGVRRNPGSWYDKELYY 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	625/997 (63%)
		Cation_ATPase_N	58..132	CDD:214842	35/73 (48%)
		E1-E2_ATPase	152..383	CDD:278548	149/230 (65%)
		Cation_ATPase	445..539	CDD:289987	67/93 (72%)
		COG4087	<695..770	CDD:226572	61/74 (82%)
		Cation_ATPase_C	817..1025	CDD:279079	104/208 (50%)
atp4a	XP_031762229.1	ATPase-IIC_X-K	39..1031	CDD:273445	622/991 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930