DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and atp7a

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001361526.1	Gene:	atp7a / 100170482	XenbaseID:	XB-GENE-1010489	Length:	1501	Species:	Xenopus tropicalis

Alignment Length:	849	Identity:	177/849 - (20%)
Similarity:	316/849 - (37%)	Gaps:	240/849 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 GFAMLLWIGAILCFVA-------YSIQASTSEEPADDNLYLGIVL--------SAVVIVTGIF-- 164
            |.:::..:..:||...       :.|||..:.:....|:.:.|||        |.:|::..||
Frog   712 GLSIMNLVSLLLCIPVQFLGGWYFYIQAYKALKHRTANMDVLIVLATSVAFIYSLIVLIVAIFEK 776

  Fly   165 -------------------------SYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLV 204
                                     .:..:||:|:.:....::....|||:......|:::|:.|
Frog   777 SKVNPITFFDTPPMLFVFIALGRWLEHIAKSKTSEALSRLISLQATEATVVILDPDNTVKSEEQV 841

  Fly   205 ------LGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSR--GAEFTHENPLETKNLA 261
                  .||:|.|..|.:.|.|.|:||.::. ||.|.:|||:.|.|:  |:.....:..:..:|.
Frog   842 DVELVQRGDIVRVTPGGKFPVDGRVIEGQSM-VDESLITGEAMPVSKKPGSSVIAGSINQNGSLL 905

  Fly   262 FFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIA----KEIHHFIHLITGVAVFLGV 322
            ..:|:.            |..|.:.:|..|.....|.:.||.    |...:|:..|..|:|   :
Frog   906 IAATHV------------GSDTTLSQIVKLVEDAQTSKAPIQQFADKLSGYFVPFIVAVSV---L 955

  Fly   323 TFFVIAFILGYHWLDAV--------------------IFLIGIIVANV--PEGL-LATVTVCLTL 364
            |.|| ..|:|||..:.|                    .|...|.|..:  |..| |||.|..:..
Frog   956 TLFV-WIIIGYHNFEIVEKYFPGYNKSISKGEVIVRFAFQAAITVLCIACPCSLGLATPTAVMVG 1019

  Fly   365 TAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQY 429
            |... |....|:|..|.:|......|:..|||||:|:....|..:   ..::|::
Frog  1020 TGVG-AQNGILIKGGEPLEMAHKVKTVVFDKTGTITKGTPVVMQV---KVLVESN---------- 1070

  Fly   430 DRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGD---------ASEAALLKCMELALGDV 485
              ..|..|.|:.:.|..:.:|...|...:...|:.::.:         |.....:.|      .|
Frog  1071 --RMPSNKLLAIVGTAESNSEHPLGSAVIKYCKEVLNAETLGTCYDFQAVPGCGISC------KV 1127

  Fly   486 MNI-----------RKRNKKIAEVPFNSTN----KYQVSIHETEDTNDPRYLLVMKGAPERILER 535
            .||           .|||..:.::.....:    ...||.:.:..::.|:...|:.|..|.:...
Frog  1128 NNIEPLLHAANGPDNKRNAVLVQIDGQHEDSILPSITVSQNPSNGSSPPQTYSVLIGNREWMNRN 1192

  Fly   536 CSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDN 600
            ..|:... .:.::.|..|:......:.:.|:      .|
Frog  1193 FLTLTAE-TDSLMTEHEKKGRTAVLVAVDGV------LC-------------------------- 1224

  Fly   601 LRFVGLMSMID--PPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIA 663
                ||:::.|  .|.||:  |:...||.|:.::::|||:..|||.||..|||..
Frog  1225 ----GLIAIADTVKPEAAL--AIHSLRSMGLDIVLMTGDNSKTAKTIAAQVGITK---------- 1273

  Fly   664 QRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGA 728
                                                       |||...|..|:..|:..|..|.
Frog  1274 -------------------------------------------VFAEVLPSHKVAKVKQLQEQGT 1295

  Fly   729 IVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKS 793
            .||:.|||:||||||..||:|:.:| :|:||:.:|||::|:.::...:|..::..|.....::.:
Frog  1296 RVAMVGDGINDSPALAMADVGITIG-SGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRIN 1359

  Fly   794 IAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPF 858
            ..:.|..|:..| |..|.:.    :|:|.:....:........::|:.:......:.::|.|:..
Frog  1360 FVFALIYNLVGI-PIAAGVF----MPVGLILQPWMGSAAMAASSVSVVFSSLLLKLYRKPSREKL 1419

  Fly   859 NDKL 862
            ..::
Frog  1420 EQRV 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	177/849 (21%)
		Cation_ATPase_N	58..132	CDD:214842	3/14 (21%)
		E1-E2_ATPase	152..383	CDD:278548	71/300 (24%)
		Cation_ATPase	445..539	CDD:289987	17/117 (15%)
		COG4087	<695..770	CDD:226572	30/74 (41%)
		Cation_ATPase_C	817..1025	CDD:279079	5/46 (11%)
atp7a	NP_001361526.1	HMA	12..74	CDD:238219
		HMA	172..234	CDD:238219
		HMA	279..336	CDD:238219
		HMA	384..447	CDD:238219
		HMA	497..559	CDD:238219
		HMA	572..632	CDD:238219
		P-type_ATPase_Cu-like	657..1389	CDD:319783	174/813 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910