DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and atp1a3

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001120366.1	Gene:	atp1a3 / 100145440	XenbaseID:	XB-GENE-996131	Length:	1025	Species:	Xenopus tropicalis

Alignment Length:	1033	Identity:	780/1033 - (75%)
Similarity:	889/1033 - (86%)	Gaps:	10/1033 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HGRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRF 73
            :||:|||||||.....||.....|:         .|.||| :||||:|:.:..|||:.||:.::.
Frog     3 YGRSDSYRVATTQDNKDDESPKKGK---------GVQKKE-IDDLKKEVAMTEHKITVEEVCRKL 57

  Fly    74 QTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAS 138
            .|....||:.:||.|.|.||||||||||..||||:|||:.|||||::||||||||||.||.|.||
Frog    58 NTDCVQGLTLSKAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSILLWIGAILCFFAYGILAS 122

  Fly   139 TSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDL 203
            ..|||:.|||||||||:||||:||.||||||:|||||||||||||||.|.|||||||:.|.||::
Frog   123 MEEEPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQLNAEEV 187

  Fly   204 VLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAV 268
            |:||:||||.|||:|||:|||.:...||||||||||||||:|..:.||||||||:|:||||||.|
Frog   188 VVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPDCTHENPLETRNIAFFSTNCV 252

  Fly   269 EGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGY 333
            ||||:|:|::.||.|||||||.|||||:.|:|||||||.|||||||||||||||||||::.||||
Frog   253 EGTARGIVVATGDRTVMGRIATLASGLEVGKTPIAKEIEHFIHLITGVAVFLGVTFFVLSLILGY 317

  Fly   334 HWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGT 398
            .||:|||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
Frog   318 TWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGT 382

  Fly   399 LTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKK 463
            |||||||||||||||||.||||||||||..:|::||.:..|:|||.|||||.||.|.|.:|:||:
Frog   383 LTQNRMTVAHMWFDNQIHEADTTEDQSGASFDKSSPTWLGLARIAALCNRAVFKAGNDNIPVLKR 447

  Fly   464 EVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGA 528
            :|:|||||:|||||:||:.|.|..:|:::||:||:|||||||||:|||||||.||.|||||||||
Frog   448 DVAGDASESALLKCIELSCGSVKAMREKSKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGA 512

  Fly   529 PERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDD 593
            |||||:.||||.|.|||:.||:|:||||.|||:|||||||||||||.:..|.:.:|.||.|:|:|
Frog   513 PERILDVCSTILIQGKEQPLDDELKEAFQNAYLELGGLGERVLGFCHYYFPEELHPKGFAFDTED 577

  Fly   594 INFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNET 658
            :||..:||.|||||||||||||||||||.|||||||||||||||||||||||||.||||||||||
Frog   578 LNFSTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNET 642

  Fly   659 VEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGC 723
            |||||.|||||||:||||:|||.|:||.:|:|:|::|:||||:.|||||||||||||||||||||
Frog   643 VEDIAARLNIPVSQVNPRDAKACVIHGTDLKDMSTEQIDEILQNHTEIVFARTSPQQKLIIVEGC 707

  Fly   724 QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 788
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   708 QRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 772

  Fly   789 NLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRP 853
            |||||||||||||||||:|||.||:.:|||||||:||||||||||||||||||||.||:|||||.
Frog   773 NLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQ 837

  Fly   854 PRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTD 918
            ||:|..|||||.|||||||||||||||..|||.||||:|||||||..|.|||..||.::||||.|
Frog   838 PRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPSHLIGIRLTWDDRSVNDLED 902

  Fly   919 SYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLA 983
            ||||:|||..||.:|:|||||||:|||||||||:|||||||||:|||||:|..|.|||..||.||
Frog   903 SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADVIICKTRRNSVFQQGMKNKILIFGLFEETALA 967

  Fly   984 AFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            |||||||||:..|||||||..|||.|.|::..||:|||.|:..|||:||||:|:|:||
Frog   968 AFLSYCPGMDIALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRHPGGWVEKESYY 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	765/995 (77%)
		Cation_ATPase_N	58..132	CDD:214842	44/73 (60%)
		E1-E2_ATPase	152..383	CDD:278548	184/230 (80%)
		Cation_ATPase	445..539	CDD:289987	66/93 (71%)
		COG4087	<695..770	CDD:226572	70/74 (95%)
		Cation_ATPase_C	817..1025	CDD:279079	157/207 (76%)
atp1a3	NP_001120366.1	ATPase-IIC_X-K	30..1025	CDD:273445	765/995 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	335	1.000	Domainoid score	I1133
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H113729
Inparanoid	1	1.050	1570	1.000	Inparanoid score	I90
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm48370
Panther	1	1.100	-	-	O	PTHR43294
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160