DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and atp2b3

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_012823355.1	Gene:	atp2b3 / 100125191	XenbaseID:	XB-GENE-977575	Length:	1242	Species:	Xenopus tropicalis

Alignment Length:	1177	Identity:	307/1177 - (26%)
Similarity:	502/1177 - (42%)	Gaps:	317/1177 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DDNRTADGQYKSRRK-------MPAKVNKKENLDDLK-----QELDIDFHKISPEELYQRFQTHP 77
            |.|.:.|...|::|:       ....:.:..:|.:|:     |::...:..::  .|.:|.:|.|
Frog     3 DLNSSVDFYQKNQRREQNHAGGFGCTLQELRSLMELRGSEAIQKIQDSYGDVN--GLCRRLKTSP 65

  Fly    78 ENGLSHAKAKENLERD--GPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTS 140
            ..|||...|.....|.  |.|.: |||:...:::..........:::...|.:..:..|..|...
Frog    66 TEGLSENIADFEKRRQIYGVNFI-PPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYAPPG 129

  Fly   141 EEPADDN-----------------------LYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNM 182
            |:  .||                       :.|.::  .||:||. |:.:.:.|..:.::|....
Frog   130 EQ--SDNCGNVSGGGHDEGEAEAGWIEGAAILLSVI--CVVLVTA-FNDWSKEKQFRGLQSRIEQ 189

  Fly   183 VPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGA 247
            ..:| :|||.|:.:.:...:|::||:.::|:||.:|||..:|:..:.|:|.|||||||:...:..
Frog   190 EQRF-SVIRNGQVVQIPVAELIVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSV 253

  Fly   248 EFTHENPLETKNLAFFSTNAVEGTAKGVVISCG-------------------------------- 280
            |   ::|     :....|:.:||:.:.||.:.|
Frog   254 E---KDP-----MLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKASKSAVN 310

  Fly   281 DHTVMGRIAGLASGLDTGE---------------------------------------------- 299
            .|.:....|.|.||...|:
Frog   311 AHQITAANAFLPSGYINGKQQDGAVETNQNKAKKQDGAVAMEMQPLKSAEGGEMEEREKKKASVP 375

  Fly   300 -----------TPIAKEIHHFIHLITGVAVFLGVTFFVI-AFIL-GYHWLD----------AVIF 341
                       |.:|.:|.....:::.:.|.:.|.:||| .|:: |..||.          ...|
Frog   376 KKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIQTFVVDGKVWLTECTPVYVQYFVKFF 440

  Fly   342 LIG--IIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRM 404
            :||  ::|..|||||...||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.|||
Frog   441 IIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRM 505

  Fly   405 TVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKAL----SRIATLCNRA------EFKGGQDGVP 459
            ||         ::::..:..:..:.|.:|...|.|    :.||..|...      |.:|.
Frog   506 TV---------VQSNIGDIHNKDKPDPSSINHKILDLLVNAIAINCAYTTKILPPEKEGA----- 556

  Fly   460 ILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIA-EVP---------FNSTNKYQVSIHETE 514
             |.::| |:.:|.||       ||.|:::::..:.:. ::|         |||..|...:|....
Frog   557 -LPQQV-GNKTECAL-------LGFVLDMQRDYQLVRDQIPEETLYKVYTFNSVRKSMSTIIRLP 612

  Fly   515 DTNDPRYLLVMKGAPERILERCSTIFING------KEKVLDEEMKEAFNNAYMELGGLGERVLGF 573
            :..   :.|..|||.|.:|::||.|..:.      :.:..:|.:|:....  |...||....:.:
Frog   613 NGG---FRLYSKGASEIVLKKCSNILNSAGDLRAFRARDREEMVKKVIEP--MACDGLRTICIAY 672

  Fly   574 CDFM-LPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGD 637
            .||. :|..::.|.        |..:.:|..:|::.:.||.|..||:|:.||:.|||.|.|||||
Frog   673 RDFPGVPEPEWENE--------NEIVCDLTCIGVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGD 729

  Fly   638 HPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEI--- 699
            :..||:|||...|||..|    ||.   |.:...|.|.|...       |..::..::||:|
Frog   730 NINTARAIAAKCGIIQPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERLDKIWPK 780

  Fly   700 LRYHTEIVFARTSPQQKLIIVEGC-------QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGS 757
            ||     |.||:||..|..:|:|.       ||.  :|||||||.||.|||||||:|.|||:||:
Frog   781 LR-----VLARSSPTDKHTLVKGIIDSTIGEQRQ--VVAVTGDGTNDGPALKKADVGFAMGLAGT 838

  Fly   758 DVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAF----ILCDIPL 818
            ||:|:|:|:||.||||:|||..|..||.::|::.|.:.:.||.|:  ::..:||    |..|.||
Frog   839 DVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQDSPL 901

  Fly   819 PLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP---RDPFNDKLVNSRLISMAYGQIGMIQA 880
            .  .|.:|.::|..|...:::||.|.....::.|.|   ..|...:.:...::..|..|:.:|..
Frog   902 K--AVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAVYQLIIIFT 964

  Fly   881 A--AG------------------------FFVYFVIM-AENGFLPKKLFGIRKMWDSKAVNDLTD 918
            .  ||                        .|..||:| ..|....:|:.|.|.::|....|.:
Frog   965 LLFAGEIFFDIDSGRNAPLHAPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPI-- 1027

  Fly   919 SYGQEWTYRDRKTLEYTCHT---AFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFG---LV 977
                            .|..   .|.:.|::||:..........|:  ||.:  |.|..|   ||
Frog  1028 ----------------FCSIVLGTFGVQILIVQFGGKPFSCAPLNA--QQWL--WCLFVGVGELV 1072

  Fly   978 FETVLAA 984
            :..|:||
Frog  1073 WGQVIAA 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	302/1150 (26%)
		Cation_ATPase_N	58..132	CDD:214842	15/75 (20%)
		E1-E2_ATPase	152..383	CDD:278548	76/333 (23%)
		Cation_ATPase	445..539	CDD:289987	26/109 (24%)
		COG4087	<695..770	CDD:226572	44/84 (52%)
		Cation_ATPase_C	817..1025	CDD:279079	43/204 (21%)
atp2b3	XP_012823355.1	ATPase-IIB_Ca	13..1083	CDD:273668	304/1167 (26%)
		Cation_ATPase_N	50..119	CDD:279080	15/71 (21%)
		E1-E2_ATPase	156..484	CDD:278548	77/339 (23%)
		Cation_ATPase	545..634	CDD:289987	25/105 (24%)
		HAD	<706..825	CDD:289480	57/139 (41%)
		Cation_ATPase_C	899..1077	CDD:279079	40/201 (20%)
		ATP_Ca_trans_C	1122..1169	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920