DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NRAS and let-60

DIOPT Version :9

Sequence 1:	NP_002515.1	Gene:	NRAS / 4893	HGNCID:	7989	Length:	189	Species:	Homo sapiens
Sequence 2:	NP_502213.3	Gene:	let-60 / 178104	WormBaseID:	WBGene00002335	Length:	184	Species:	Caenorhabditis elegans

Alignment Length:	181	Identity:	139/181 - (76%)
Similarity:	157/181 - (86%)	Gaps:	0/181 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65
            ||||||||||.||||||||||||||||||:|||||||||||||||||||||||||||||||||||
Worm     1 MTEYKLVVVGDGGVGKSALTIQLIQNHFVEEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65

Human    66 AMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQA 130
            ||||||||||||||.|||:|.:|||.::..|||||:|||||||||||||||||||.:|:||.:..
Worm    66 AMRDQYMRTGEGFLLVFAVNEAKSFENVANYREQIRRVKDSDDVPMVLVGNKCDLSSRSVDFRTV 130

Human   131 HELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGC 181
            .|.||.||||.::||||||.||::||||||||||::|.:..|:.....:.|
Worm   131 SETAKGYGIPNVDTSAKTRMGVDEAFYTLVREIRKHRERHDNNKPQKKKKC 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NRAS	NP_002515.1	H_N_K_Ras_like	3..164	CDD:133338	132/160 (83%)
		Effector region	32..40		7/7 (100%)
		Hypervariable region	166..185		3/16 (19%)
let-60	NP_502213.3	H_N_K_Ras_like	3..164	CDD:133338	132/160 (83%)
let-60	NP_502213.3	small_GTPase	16..166	CDD:197466	122/149 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1094
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	284	1.000	Inparanoid score	I1975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	1	1.000	-	-		otm15429
orthoMCL	1	0.900	-	-		OOG6_100217
Panther	1	1.100	-	-	O	PTHR24070
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870