DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)73Ah and PCGF6

DIOPT Version :9

Sequence 1:	NP_001246797.1	Gene:	l(3)73Ah / 48903	FlyBaseID:	FBgn0002283	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_001011663.1	Gene:	PCGF6 / 84108	HGNCID:	21156	Length:	350	Species:	Homo sapiens

Alignment Length:	209	Identity:	87/209 - (41%)
Similarity:	128/209 - (61%)	Gaps:	20/209 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ERRVKLKTINPHITCKICGGYFIDATTVTECLHTFCKSCLVKHLEEKKTCPTCDNIIHQSHPLQY 66
            ||.:.|..:.|:|.|.||.||.|||||:|||||||||||:|:|......||.|:.::||:.||..
Human   120 ERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYN 184

  Fly    67 ISFDRTMQDIVYKLVPKLQEDESRRERDFYKSRNMPCPKDI----TQNHEDDNEKVMDAHAESDF 127
            |..||.:||||||||..|:|.|.::..||||.|.:..||..    ..:.:..::||:    ||.|
Human   185 IRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVL----ESVF 245

  Fly   128 H---RLDEQVNVCLECISNN-----FKNLQRRFIRCSSQATITHLKKLVAKKILNGIEKYREIDI 184
            .   .||  :::.||.|..|     ||.|:::|:|.|.:|||.|::|.:.:|:  |::...::||
Human   246 RIPPELD--MSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKM--GLDPACQVDI 306

  Fly   185 LCNEELLGKDHTLK 198
            :|.:.||.:..||:
Human   307 ICGDHLLEQYQTLR 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)73Ah	NP_001246797.1	RING-HC_PCGF3	13..59	CDD:319649	27/45 (60%)
l(3)73Ah	NP_001246797.1	RAWUL_PCGF3	133..217	CDD:340603	24/71 (34%)
PCGF6	NP_001011663.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115
		zf-C3HC4	134..172	CDD:278524	25/37 (68%)
		RAWUL	270..>319	CDD:292824	17/50 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1203951at2759
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820