Protein Alignment l(3)73Ah and Pcgf1

DIOPT Version :10

• Sequence 1: NP_524933.1
• Gene: l(3)73Ah / 48903
• FlyBaseID: FBgn0002283
• Length: 222
• Species: Drosophila melanogaster
• Sequence 2: NP_932109.2
• Gene: Pcgf1 / 69837
• MGIID: 1917087
• Length: 259
• Species: Mus musculus
• Alignment Length: 228
• Identity: 92/228 - (40%)
• Similarity: 145/228 - (63%)
• Gaps: 21/228 - (9%)

  Fly     2 ERRVKLKTINPHITCKICGGYFIDATTVTECLHTFCKSCLVKHLEEKKTCPTCDNIIHQSHPLQY 66
            |.|||:|.:|.||.|.:|.|||:||||:|||||||||||:||:|:..|.||.|:..||::.||..
Mouse    33 EVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLN 97

  Fly    67 ISFDRTMQDIVYKLVPKLQEDESRRERDFYKSRNMPCPKDITQNHEDDNEKVMDA--------HA 123
            :..||.||||||||||.||:.|.:|.|:||:||.:    |.......:...:.:.        |:
Mouse    98 LKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL----DRVSQPSGEEPALSNLGLPFSSFDHS 158

  Fly   124 ESDFHRLDEQVNVCLECISN----NFKNLQRRFIRCSSQATITHLKKLVAKKI-LNGIEKYREID 183
            ::.::|.|||:::|||.:|:    |...||.:::|||.:|.:.||::::..:: ||.    :.:.
Mouse   159 KAHYYRYDEQLSLCLERLSSGKDKNKNVLQNKYVRCSVRAEVRHLRRVLCHRLMLNP----QHVQ 219

  Fly   184 ILCNEELLGKDHTLKFVYVTRWRFRDPPLRLQF 216
            :|.:.|:|....|:|.::::||..:..||.||:
Mouse   220 LLFDNEVLPDHMTMKQLWLSRWFGKPSPLLLQY 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)73Ah	NP_524933.1	RING_Ubox	4..96	CDD:473075	55/91 (60%)
		RAWUL_PCGF3	133..217	CDD:340603	27/89 (30%)
Pcgf1	NP_932109.2	RING-HC_PCGF1	36..106	CDD:438391	40/69 (58%)
		Necessary for repressor activity. /evidence=ECO:0000250	86..247		53/168 (32%)
		Required for the interaction with the KDM2B-SKP1 heterodimeric complex. /evidence=ECO:0000250|UniProtKB:Q9BSM1	150..255		31/107 (29%)
		RAWUL_PCGF1	166..253	CDD:340601	29/91 (32%)
		RING-finger and WD40-associated ubiquitin-like domain (RAWUL), sufficient for interaction with BCOR and BCORL1. /evidence=ECO:0000250|UniProtKB:Q9BSM1	167..255		28/90 (31%)