DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)73Ah and BMI1

DIOPT Version :9

Sequence 1:	NP_001246797.1	Gene:	l(3)73Ah / 48903	FlyBaseID:	FBgn0002283	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_005171.4	Gene:	BMI1 / 648	HGNCID:	1066	Length:	326	Species:	Homo sapiens

Alignment Length:	230	Identity:	93/230 - (40%)
Similarity:	136/230 - (59%)	Gaps:	21/230 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RVKLKTINPHITCKICGGYFIDATTVTECLHTFCKSCLVKHLEEKKTCPTCDNIIHQSHPLQYIS 68
            |:|:..:|||:.|.:||||||||||:.||||:|||:|:|::||..|.||.||..:|::.||..|.
Human     6 RIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIR 70

  Fly    69 FDRTMQDIVYKLVPKLQEDESRRERDFYKSRNMPCPKDITQNHED-----DNEK--VMDAHAES- 125
            .|:|:|||||||||.|.::|.:|.||||.:.  |.......::||     |.:|  :.|....|
Human    71 SDKTLQDIVYKLVPGLFKNEMKRRRDFYAAH--PSADAANGSNEDRGEVADEDKRIITDDEIISL 133

  Fly   126 -----DFHRLDEQVNVCLECISNNFKNLQRRFIRCSSQATITHLKKLVAKKILNGIEKYREIDIL 185
                 |.:|||.:||...|.......:  :|::||.:..|:.||:|.:..|:  .|....:||::
Human   134 SIEFFDQNRLDRKVNKDKEKSKEEVND--KRYLRCPAAMTVMHLRKFLRSKM--DIPNTFQIDVM 194

  Fly   186 CNEELLGKDHTL-KFVYVTRWRFRDPPLRLQFRPR 219
            ..||.|...:|| ...|:..|| |:.||.|::|.|
Human   195 YEEEPLKDYYTLMDIAYIYTWR-RNGPLPLKYRVR 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)73Ah	NP_001246797.1	RING-HC_PCGF3	13..59	CDD:319649	28/45 (62%)
l(3)73Ah	NP_001246797.1	RAWUL_PCGF3	133..217	CDD:340603	26/84 (31%)
BMI1	NP_005171.4	RING-HC_PCGF4	12..65	CDD:319650	31/52 (60%)
		Nuclear localization signal. /evidence=ECO:0000255	81..95		7/13 (54%)
		RAWUL_PCGF4	130..226	CDD:340685	31/100 (31%)
		Interaction with PHC2. /evidence=ECO:0000269\|PubMed:27827373	162..182		7/19 (37%)
		Interaction with E4F1. /evidence=ECO:0000269\|PubMed:16882984	164..228		23/66 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..326
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S517
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.760