DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)73Ah and PCGF3

DIOPT Version :9

Sequence 1:	NP_001246797.1	Gene:	l(3)73Ah / 48903	FlyBaseID:	FBgn0002283	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_001304765.1	Gene:	PCGF3 / 10336	HGNCID:	10066	Length:	242	Species:	Homo sapiens

Alignment Length:	242	Identity:	135/242 - (55%)
Similarity:	172/242 - (71%)	Gaps:	22/242 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERRVKLKTINPHITCKICGGYFIDATTVTECLHTFCKSCLVKHLEEKKTCPTCDNIIHQSHPLQ 65
            :.|::||..||.||||::|.||.||||||||||||||:|||||:|||..|||||..:||||||||
Human     2 LTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQ 66

  Fly    66 YISFDRTMQDIVYKLVPKLQEDESRRERDFYKSRNMPCPKDI----------TQNHEDDNEKVMD 120
            ||..|||||||||||||.|||.|.|::|:||....|..|.||          ..:|.:...|..|
Human    67 YIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADD 131

  Fly   121 A----------HAESDFHRLDEQVNVCLECISNNFKNLQRRFIRCSSQATITHLKKLVAKKILNG 175
            :          ..::|:||.||||::||||.|:..:.|:|::||||:|||:.||||.:|||:  .
Human   132 SSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKL--N 194

  Fly   176 IEKYREIDILCNEELLGKDHTLKFVYVTRWRFRDPPLRLQFRPRVEL 222
            :..:.|:|||||||:||||||||||.||||||:..||.|.:||:::|
Human   195 LSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDL 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)73Ah	NP_001246797.1	RING-HC_PCGF3	13..59	CDD:319649	34/45 (76%)
l(3)73Ah	NP_001246797.1	RAWUL_PCGF3	133..217	CDD:340603	50/83 (60%)
PCGF3	NP_001304765.1	RING-HC_PCGF3	14..60	CDD:319649	34/45 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..149		4/33 (12%)
		Interaction with BCORL1. /evidence=ECO:0000269\|PubMed:27568929	132..242		58/112 (52%)
		RAWUL_PCGF3	154..236	CDD:340603	50/83 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159805
Domainoid	1	1.000	99	1.000	Domainoid score	I7159
eggNOG	1	0.900	-	-		E1_KOG2660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4605
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2881
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48635
OrthoDB	1	1.010	-	-		D1203951at2759
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	1	1.000	-	-		oto90472
orthoMCL	1	0.900	-	-		OOG6_107223
Panther	1	1.100	-	-	LDO	PTHR45893
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3764
SonicParanoid	1	1.000	-	-		X607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800