DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)73Ah and COMMD3-BMI1

DIOPT Version :9

Sequence 1:	NP_001246797.1	Gene:	l(3)73Ah / 48903	FlyBaseID:	FBgn0002283	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_001190991.1	Gene:	COMMD3-BMI1 / 100532731	HGNCID:	48326	Length:	469	Species:	Homo sapiens

Alignment Length:	230	Identity:	93/230 - (40%)
Similarity:	136/230 - (59%)	Gaps:	21/230 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RVKLKTINPHITCKICGGYFIDATTVTECLHTFCKSCLVKHLEEKKTCPTCDNIIHQSHPLQYIS 68
            |:|:..:|||:.|.:||||||||||:.||||:|||:|:|::||..|.||.||..:|::.||..|.
Human   149 RIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIR 213

  Fly    69 FDRTMQDIVYKLVPKLQEDESRRERDFYKSRNMPCPKDITQNHED-----DNEK--VMDAHAES- 125
            .|:|:|||||||||.|.::|.:|.||||.:.  |.......::||     |.:|  :.|....|
Human   214 SDKTLQDIVYKLVPGLFKNEMKRRRDFYAAH--PSADAANGSNEDRGEVADEDKRIITDDEIISL 276

  Fly   126 -----DFHRLDEQVNVCLECISNNFKNLQRRFIRCSSQATITHLKKLVAKKILNGIEKYREIDIL 185
                 |.:|||.:||...|.......:  :|::||.:..|:.||:|.:..|:  .|....:||::
Human   277 SIEFFDQNRLDRKVNKDKEKSKEEVND--KRYLRCPAAMTVMHLRKFLRSKM--DIPNTFQIDVM 337

  Fly   186 CNEELLGKDHTL-KFVYVTRWRFRDPPLRLQFRPR 219
            ..||.|...:|| ...|:..|| |:.||.|::|.|
Human   338 YEEEPLKDYYTLMDIAYIYTWR-RNGPLPLKYRVR 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)73Ah	NP_001246797.1	RING-HC_PCGF3	13..59	CDD:319649	28/45 (62%)
l(3)73Ah	NP_001246797.1	RAWUL_PCGF3	133..217	CDD:340603	26/84 (31%)
COMMD3-BMI1	NP_001190991.1	HCaRG	20..>125	CDD:284632
		zf-C3HC4	161..199	CDD:278524	25/37 (68%)
		RAWUL	291..369	CDD:292824	25/82 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810