Protein Alignment ATP2A3 and PMR1

DIOPT Version :10

• Sequence 1: XP_011522183.1
• Gene: ATP2A3 / 489
• HGNCID: 813
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_011348.1
• Gene: PMR1 / 852709
• SGDID: S000003135
• Length: 950
• Species: Saccharomyces cerevisiae
• Alignment Length: 1005
• Identity: 317/1005 - (31%)
• Similarity: 509/1005 - (50%)
• Gaps: 130/1005 - (12%)

Human     7 LPAADVLRHFSVTAEGGL-SPAQVTGARERYGPNELPSEEGKSLWELVLEQF-EDLLVRILLLAA 69
            |...:.|........||| |..:....|..|||||:..|:.:||::..|..| ||.::.:|:.:|
Yeast    41 LSVDEALEKLDTDKNGGLRSSNEANNRRSLYGPNEITVEDDESLFKKFLSNFIEDRMILLLIGSA 105

Human    70 LVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDR 134
            :||..:...::....|      |.|.:::.    ||..||..:|.::|||.:..|....::|..:
Yeast   106 VVSLFMGNIDDAVSIT------LAIFIVVT----VGFVQEYRSEKSLEALNKLVPAECHLMRCGQ 160

Human   135 KGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAI----- 194
            :  ..:.|..:||||:|...:||::|||:|:||  :..|.:|:|.||||:..|.|.::.|
Yeast   161 E--SHVLASTLVPGDLVHFRIGDRIPADIRIIE--AIDLSIDESNLTGENEPVHKTSQTIEKSSF 221

Human   195 ---PDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEF 256
               |:......::..:.:.||.:..|...|:.|.||.:|..|.:...|..:|..:||||..:|:.
Yeast   222 NDQPNSIVPISERSCIAYMGTLVKEGHGKGIVVGTGTNTSFGAVFEMMNNIEKPKTPLQLTMDKL 286

Human   257 GRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLAL 321
            |:.||....::...:.::.|      ..|.|||.    .|:|:|:|||||||||||.::|..|||
Yeast   287 GKDLSLVSFIVIGMICLVGI------IQGRSWLE----MFQISVSLAVAAIPEGLPIIVTVTLAL 341

Human   322 GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTI-- 384
            |..|||::.||||.||||||||..:|||||||||||:|.|:|.:::.:   |:.|..|:..::
Yeast   342 GVLRMAKRKAIVRRLPSVETLGSVNVICSDKTGTLTSNHMTVSKLWCL---DSMSNKLNVLSLDK 403

Human   385 SGTTYTPEGEVRQG-DQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCL 448
            :..|....|.::.. .:.||        |..||..|||:::  :::...::  :|..|:.||
Yeast   404 NKKTKNSNGNLKNYLTEDVR--------ETLTIGNLCNNAS--FSQEHAIF--LGNPTDVAL--- 453

Human   449 VEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMF 513
                      |:.|:..|.....|||     :|...|.|:..||.|:....    :|......::
Yeast   454 ----------LEQLANFEMPDIRNTV-----QKVQELPFNSKRKLMATKIL----NPVDNKCTVY 499

Human   514 VKGAPESVIERCSSV--RVGSRTAPLTPTSREQILAKIRDWGS--GSDTLRCLALA----TRDAP 570
            ||||.|.::|..:|.  ..|.:|..||...:    |.|.:..:  .|:.||....|    :..:.
Yeast   500 VKGAFERILEYSTSYLKSKGKKTEKLTEAQK----ATINECANSMASEGLRVFGFAKLTLSDSST 560

Human   571 PRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
            |..||:           ..||||.|.:||.|||||.|...|.:..|.|:.::|||||::.|||.|
Yeast   561 PLTEDL-----------IKDLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITGDSENTAVNI 614

Human   636 CRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAM 700
            .:::||  ...|......:|.:.|::|.:|..........|||..|.||..||..|:...::.||
Yeast   615 AKQIGI--PVIDPKLSVLSGDKLDEMSDDQLANVIDHVNIFARATPEHKLNIVRALRKRGDVVAM 677

Human   701 TGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYL 764
            ||||||||||||.::||::||. ||.|||.|::|||:||:|::|:.|:|||:.|::|::.|:.:.
Yeast   678 TGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFSTILTAIEEGKGIFNNIQNFLTFQ 742

Human   765 ISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALI 829
            :|::|..:..:.|:....||..|..:|:||:|::.||.||.:||..|.|.::|:|.||...:.::
Yeast   743 LSTSVAALSLVALSTAFKLPNPLNAMQILWINILMDGPPAQSLGVEPVDHEVMKKPPRKRTDKIL 807

Human   830 SGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESR 894
            :..:..|.|.....:.:.||      :::..|              .:||..:.|.
Yeast   808 THDVMKRLLTTAACIIVGTV------YIFVKE--------------MAEDGKVTAR--------- 843

Human   895 FPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQV 959
             .|||..:..|..:|.|||......:|:..:..:.|.....||.:|:......:.:|....||:.
Yeast   844 -DTTMTFTCFVFFDMFNALACRHNTKSIFEIGFFTNKMFNYAVGLSLLGQMCAIYIPFFQSIFKT 907

Human   960 TPLSGRQWVVVLQISLPVILLDEALKYLSR 989
            ..|.....:::|.||..|.::||..|..:|
Yeast   908 EKLGISDILLLLLISSSVFIVDELRKLWTR 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A3	XP_011522183.1	P-type_ATPase_SERCA	5..989	CDD:319778	316/1003 (32%)
PMR1	NP_011348.1	ATPase-IIA2_Ca	35..940	CDD:130585	317/1005 (32%)