Protein Alignment ATP2A3 and ENA5

DIOPT Version :10

• Sequence 1: XP_011522183.1
• Gene: ATP2A3 / 489
• HGNCID: 813
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_010323.3
• Gene: ENA5 / 851608
• SGDID: S000002445
• Length: 1091
• Species: Saccharomyces cerevisiae
• Alignment Length: 1098
• Identity: 307/1098 - (27%)
• Similarity: 496/1098 - (45%)
• Gaps: 204/1098 - (18%)

Human     3 AAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLL 67
            |.|.|...:.......:...||:..:.....:..|.|.|..:.......:||.|..:.::.:|::
Yeast    16 AYHTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNAMIMVLVI 80

Human    68 AALVSF-VLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIR 131
            :..:|| |..|...|           ||..::..|.::|:.||..|...:.:||........|||
Yeast    81 SMAISFAVRDWITGG-----------VISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIR 134

Human   132 SDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAI-- 194
            :.:.  :.|.::|:|||||..|.|||.:||||||||.|:  ...|:|:|||||:.|:|....:
Yeast   135 NGKS--ETINSKDVVPGDICLVKVGDTIPADLRLIETKN--FDTDESLLTGESLPVSKDANLVFG 195

Human   195 -PDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIR------SQMAAVEPER------ 246
             .:..:|. |:.|:.||.:.:..|:|.|:.:.|.|::|:|||.      |.:.:.:|.:
Yeast   196 KEEETSVG-DRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNT 259

Human   247 -----------------TPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVY 294
                             |||.|||.:.. .|...|:|:...:.:.:.....|.       |.|:|
Yeast   260 WISTKKVTGAFLGTNVGTPLHRKLSKLA-VLLFWIAVLFAIIVMASQKFDVDK-------RVAIY 316

Human   295 YFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTN 359
                |:.:|::.||..|..|:|..:::|...|..:|.|||.|.|:|.||..:.||||||||||..
Yeast   317 ----AICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQG 377

Human   360 QMSVCRMFV-------VAEAD-------AGSCLLHEFTISGTTYTPEGEV----------RQGDQ 400
            :|...::::       ::.:|       ....|:..|:....::..:|:|          .:.|.
Yeast   378 KMLARQIWIPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDL 442

Human   401 P--VRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNV--------- 454
            |  :....|...:|.||   |.|.:.:..::|...::..|:.||.|:.....||::
Yeast   443 PEDIDMDLFQKWLETAT---LANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEK 504

Human   455 -----FDTDLQALSR-VERAGACNTVIKQLMRKEFTLEFSRD---RKSMSVYCTPTRPHPTGQGS 510
                 .:.|..:||: .|:.|:.        :.|...||..|   ::..|||.     :...:..
Yeast   505 STNQSNENDQSSLSQHNEKPGSA--------QFEHIAEFPFDSTVKRMSSVYY-----NNHNETY 556

Human   511 KMFVKGAPESVIERCSS--VRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRK 573
            .::.|||.||:|..|||  .:.|.:..|||....|.|...:  :...::.||.|..|::..   .
Yeast   557 NIYGKGAFESIISCCSSWYGKDGVKITPLTDCDVETIRKNV--YSLSNEGLRVLGFASKSF---T 616

Human   574 EDMELDD-----CSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAV 633
            :|...||     .|.....|:||.|:|.:|:.||||.|.|..:.:.:||||.|.|:|||..|||.
Yeast   617 KDQVNDDQLKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAK 681

Human   634 AICRRLGIFG------DTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQ 692
            ||.:.:||..      ..|.|.....||.:||.||.|:...........||..|..|.|::|.|.
Yeast   682 AIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALH 746

Human   693 SFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSN 756
            ...:..|||||||||:|:||.|.:||||| :|:.|:|.|:::||||||||||:.||||||.:..|
Yeast   747 RRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDN 811

Human   757 MKQFIRYLISSNVGEVVCIFLTAILGL-----------PEALIPVQLLWVNLVTDGLPATALGFN 810
            :::|:..|::.||.:.    |..|:||           |  |.||::||:.:||...||..||..
Yeast   812 IQKFVLQLLAENVAQA----LYLIIGLVFRDENGKSVFP--LSPVEVLWIIVVTSCFPAMGLGLE 870

Human   811 PPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLK 875
            ....|:|::.|......:.:..:.....|.|:.:..:.:|:    |.....|  ||..:|
Yeast   871 KAAPDLMDRPPNDSEVGIFTWEVIIDTFAYGIIMTGSCMAS----FTGSLYG--INSGRL----- 924

Human   876 CSEDNPLFAGIDC---------EVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPP---- 927
                     |.||         :|:.||   :.|.:.:....:..|...|...:|..||.|
Yeast   925 ---------GHDCDGTYNSSCRDVYRSR---SAAFATMTWCALILAWEVVDMRRSFFRMHPDTDS 977

Human   928 ---------WMNPWLLVAVAMSMALHFLILLVPPL-PLIFQVTPLSGRQWVVVLQISL 975
                     |.|.:|..::.......|.::.:|.: ..:|...|: |.:|.:.:..::
Yeast   978 PVKEFFRSIWGNQFLFWSIIFGFVSAFPVVYIPVINDKVFLHKPI-GAEWGLAIAFTI 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A3	XP_011522183.1	P-type_ATPase_SERCA	5..989	CDD:319778	306/1096 (28%)
ENA5	NP_010323.3	ATPase-IID_K-Na	11..1055	CDD:130586	307/1098 (28%)