Protein Alignment ATP2A3 and atp2a3

DIOPT Version :10

• Sequence 1: XP_011522183.1
• Gene: ATP2A3 / 489
• HGNCID: 813
• Length: 1114
• Species: Homo sapiens
• Sequence 2: XP_697108.5
• Gene: atp2a3 / 568671
• ZFINID: ZDB-GENE-060531-103
• Length: 1005
• Species: Danio rerio
• Alignment Length: 992
• Identity: 774/992 - (78%)
• Similarity: 885/992 - (89%)
• Gaps: 3/992 - (0%)

Human     1 MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRIL 65
            ||.||...|::||.:|.|....||:..||....::|||||||:||||||||||:|||||||||||
Zfish     1 MENAHTKSASEVLANFGVNENTGLTLEQVKNNFDKYGPNELPAEEGKSLWELVVEQFEDLLVRIL 65

Human    66 LLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
            ||||.||||||.||||||:|||||||:||:|||||||::|||||||||:|||||||||||||||.
Zfish    66 LLAACVSFVLALFEEGEESTTAFVEPIVILLILVANAVIGVWQERNAENAIEALKEYEPEMGKVY 130

Human   131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIP 195
            |.:|..||||:|||||||||||::||||||||:|:..||||||||||||||||||||.|||:.:|
Zfish   131 RMNRTAVQRIKARDIVPGDIVEISVGDKVPADIRITSIKSTTLRVDQSILTGESVSVIKHTDPVP 195

Human   196 DPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQL 260
            |||||||||||||||||||.:|:|:||.|:||:.||:||||:||||.|.|:||||:||||||:||
Zfish   196 DPRAVNQDKKNMLFSGTNIAAGRAIGVVVSTGVSTEIGKIRNQMAATEQEKTPLQQKLDEFGQQL 260

Human   261 SHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |..||:||:|||||||||||||.|||||:|||:||||||||||||||||||||||||||||||||
Zfish   261 SKVISLICIAVWVINIGHFADPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

Human   326 MARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYT 390
            ||:|||||||||||||||||||||||||||||||||||||||||.:||..||.||||||||:||.
Zfish   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVNKADDSSCSLHEFTISGSTYA 390

Human   391 PEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVF 455
            |||||.:.|:.|:||.:||||||||||:|||||:||||||||||||||||||||||.||||||||
Zfish   391 PEGEVLKADKQVQCGDYDGLVELATICSLCNDSSLDYNEAKGVYEKVGEATETALTTLVEKMNVF 455

Human   456 DTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPES 520
            .|||..||:|:||.|||.:|:|||:|:|||||||||||||||||   |:.|...||||||||||.
Zfish   456 KTDLSGLSKVDRAAACNLIIRQLMQKKFTLEFSRDRKSMSVYCT---PNGTNSQSKMFVKGAPEG 517

Human   521 VIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFV 585
            ||:||..||||....|||...:|::::.|||||:|.||||||||||||:||..:.|:|::..||.
Zfish   518 VIDRCQFVRVGKERFPLTMAVKEELMSTIRDWGTGRDTLRCLALATRDSPPAVDKMDLENAGKFA 582

Human   586 QYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAG 650
            :||:.||||||||||||||.||...|..|.:|||||:||||||||||||||||:|||.:.|||.|
Zfish   583 EYESSLTFVGCVGMLDPPRKEVIGSIKLCNKAGIRVIMITGDNKGTAVAICRRIGIFSENEDVEG 647

Human   651 KAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715
            :||||||||||:||.||:|.:.|||||||||||||:||..||||:||||||||||||||||||||
Zfish   648 RAYTGREFDDLAPEAQREAVKRARCFARVEPAHKSKIVAYLQSFDEITAMTGDGVNDAPALKKAE 712

Human   716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAI 780
            |||||||||||||||:|||||||||::||||||||||||:|||||||||||||||||||||||||
Zfish   713 IGIAMGSGTAVAKSASEMVLSDDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAI 777

Human   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVG 845
            |||||||||||||||||||||||||||||||||||||:|.||:|:|.||||||||||||||.|||
Zfish   778 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDKPPRNPKEPLISGWLFFRYLAIGGYVG 842

Human   846 LATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMC 910
            |.||:|||||:::|.:||.::|||||:|::|:|:||:|.||:|||||||:||||||||||||||.
Zfish   843 LGTVSAATWWYLFDEDGPQVSFYQLRHFMQCTEENPMFEGINCEVFESRYPTTMALSVLVTIEMF 907

Human   911 NALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISL 975
            |||||:||||||||||||:|.|||.|:.:|::||||||.|.|||||||||||...||::|.:||:
Zfish   908 NALNSLSENQSLLRMPPWVNIWLLGAIILSLSLHFLILHVEPLPLIFQVTPLHFSQWIIVFKISI 972

Human   976 PVILLDEALKYLSRNHM 992
            |||||||||||:||:|:
Zfish   973 PVILLDEALKYISRHHL 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A3	XP_011522183.1	P-type_ATPase_SERCA	5..989	CDD:319778	768/983 (78%)
atp2a3	XP_697108.5	P-type_ATPase_SERCA	5..986	CDD:319778	768/983 (78%)