Protein Alignment ATP2A3 and SERCA

DIOPT Version :10

• Sequence 1: XP_011522183.1
• Gene: ATP2A3 / 489
• HGNCID: 813
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Alignment Length: 989
• Identity: 673/989 - (68%)
• Similarity: 795/989 - (80%)
• Gaps: 0/989 - (0%)

Human     1 MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRIL 65
            ||..|.......|..|....|.||:..|:...:::|||||||:|||||:|:||||||:||||:||
  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65

Human    66 LLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
            ||||::|||||.|||.|||.|||||||||:|||:|||:||||||||||||||||||||||||||:
  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130

Human   131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIP 195
            |.|:.|:|::||::|||||:|||:||||:|||:|:..|.|||||:||||||||||||.|||:|||
  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195

Human   196 DPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQL 260
            |||||||||||:||||||:.:|||.||.:.|||.|.:||||::|:..|..:||||:||||||.||
  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260

Human   261 SHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |..|||||||||.||||||.||||||||::||:||||||||||||||||||||||||||||||||
  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

Human   326 MARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYT 390
            ||:|||||||||||||||||||||||||||||||||||.|||:..:.:.......||.::|:||.
  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390

Human   391 PEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVF 455
            |.|||....|.::...:|.|.||:|||.:|||||:||||.|..:|||||||||||..|.||:|.|
  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455

Human   456 DTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPES 520
            ..:...|.|...|.||...|:...:|||||||||||||||.||||.:....|.|.|:|||||||.
  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520

Human   521 VIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFV 585
            |:|||:..|||:...|||...:.:|||....:|:|.|||||||||..|:|.:.::|:|.|.:||.
  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585

Human   586 QYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAG 650
            |||.:|||||.||||||||.||...|.||..|||||::||||||.||.|||||:|:|.:.||..|
  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650

Human   651 KAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715
            |:|:|||||||||.:|:.|...:|.|:||||.|||:|||.|||.|||:|||||||||||||||||
  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715

Human   716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAI 780
            ||||||||||||||||||||:||||:|||:|||||||||:|||||||||||||:||||.|||||.
  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780

Human   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVG 845
            |||||||||||||||||||||||||||||||||||||||.||...|.||||||||||:|||.|||
  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845

Human   846 LATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMC 910
            .|||.||.||||:..|||.::::||.:.|.|......|.|:||::|......||||||||||||.
  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910

Human   911 NALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISL 975
            ||:||:||||||:.||||.|.||:.::|:|..|||:||.|..|..:|||||||..:|:.|::.|:
  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975

Human   976 PVILLDEALKYLSR 989
            ||:||||.||:::|
  Fly   976 PVVLLDETLKFVAR 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A3	XP_011522183.1	P-type_ATPase_SERCA	5..989	CDD:319778	670/983 (68%)
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	670/983 (68%)