Protein Alignment ATP2A3 and cta3

DIOPT Version :10

• Sequence 1: XP_011522183.1
• Gene: ATP2A3 / 489
• HGNCID: 813
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_595246.1
• Gene: cta3 / 2541204
• PomBaseID: SPBC839.06
• Length: 1037
• Species: Schizosaccharomyces pombe
• Alignment Length: 1067
• Identity: 320/1067 - (29%)
• Similarity: 505/1067 - (47%)
• Gaps: 213/1067 - (19%)

Human    11 DVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL 75
            ||...|..:...||:..:.......||.|.|.::.|.|.|:::|.|..:.:..:|:|||.:||
pombe    17 DVESEFLTSIPNGLTHEEAQNRLSEYGENRLEADSGVSAWKVLLRQVLNAMCVVLILAAALSF-- 79

Human    76 AWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRI 140
                    .||.::|..||..|:|.|..||..||..||..:::|:.....|..|.||.:  ...|
pombe    80 --------GTTDWIEGGVISAIIVLNITVGFIQEYKAEKTMDSLRTLASPMAHVTRSSK--TDAI 134

Human   141 RARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQ--- 202
            .:..:||||:|.:..||.|||||||:|  :.....|:::|||||:.|.|      |..|..|
pombe   135 DSHLLVPGDVVVLKTGDVVPADLRLVE--TVNFETDEALLTGESLPVIK------DAHATFQMNE 191

Human   203 -----DKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAA-----VEPER----------- 246
                 |:.|:.:|.:.:|.|:|.|:..|||:.|::|.|.:.:..     ..||:
pombe   192 DVPIGDRINLAYSSSIVTKGRAKGICYATGMQTQIGAIAAGLRQKGKLFQRPEKDEPNYRRKLNK 256

Human   247 -------------------TPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGA 292
                               |||||||...      |..:.|:|:.:..|...|...|..:.:  :
pombe   257 YYLKVTSYYVQRVLGLNVGTPLQRKLTVL------AYILFCIAIILAIIVMAAHSFHVTNEV--S 313

Human   293 VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLT 357
            :|    |::|.::.|||.|.||::..:|:|.:.|:::..|||.|.::|.||..:.||||||||:|
pombe   314 IY----AISLGISIIPESLIAVLSITMAMGQKNMSKRRVIVRKLEALEALGGVTDICSDKTGTIT 374

Human   358 TNQMSVCRMFV-------VAEADAGSCLLHEFTISGTTYTPEGEVRQ----------GDQPVRCG 405
            ..:|...|:::       |..:||.:..:.  |:||.....:..:::          .:||
pombe   375 QGKMITRRVWIPSYGYLSVDTSDANNPTIG--TVSGLEAAMQDVLKEKKQEMKNIDPSNQP---- 433

Human   406 QFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGA 470
             .|..:.|...|||||.|.::..|. |.:...||.||.||....::.|....||.         .
pombe   434 -SDQFIPLLKTCALCNLSTVNQTET-GEWVVKGEPTEIALHVFSKRFNYGKEDLL---------K 487

Human   471 CNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPTGQGS-KMFVKGAPESVIERCSSVRVGSRT 534
            .||.:::       ..|..:.|.|:|.      :...||. .::.|||.|.::||||:    |..
pombe   488 TNTFVRE-------YPFDSEIKRMAVI------YEDQQGQYTVYAKGAVERILERCST----SNG 535

Human   535 APLTPTSREQILAKIRDWGSGSDTLRCLALATR--DAPPRKEDMELDDCSKFVQYETDLTFVGCV 597
            :.|....||.|:|::..  ..::.||.|||||:  |.....|.:..|..      |:.|.||..|
pombe   536 STLEEPDRELIIAQMET--LAAEGLRVLALATKVIDKADNWETLPRDVA------ESSLEFVSLV 592

Human   598 GMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGI----FGDTE-DVAGKAYTGRE 657
            |:.||||.|....:..|::|||||.|:|||:..||.||.|.:||    ..|.: :::....||.:
pombe   593 GIYDPPRTESKGAVELCHRAGIRVHMLTGDHPETAKAIAREVGIIPPFISDRDPNMSWMVMTGSQ 657

Human   658 FDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG- 721
            ||.||.|:...........||..|..|.:::|.|.......|||||||||:|:||:|.:|||||
pombe   658 FDALSDEEVDSLKALCLVIARCAPQTKVKMIEALHRRKAFVAMTGDGVNDSPSLKQANVGIAMGQ 722

Human   722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGL--- 783
            :|:.|||.|:::||:||||:|||.|:||||.::.|:.:|:.:|:.||||||:.:    ::||
pombe   723 NGSDVAKDASDIVLTDDNFSSIVNAIEEGRRMFDNIMRFVLHLLVSNVGEVILL----VVGLAFR 783

Human   784 --------PEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAI 840
                    |  :.||::||.|::|...|:..||......|:||:||...:..:....|....:..
pombe   784 DEVHLSVFP--MSPVEILWCNMITSSFPSMGLGMELAQPDVMERLPHDNKVGIFQKSLIVDMMVY 846

Human   841 GVYVGLATVAAATWWFV----------YDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESR- 894
            |.::|:  |:..||..:          ||....:                  .||.: :||::|
pombe   847 GFFLGV--VSLMTWVVIMYGFGTGNLSYDCNAHY------------------HAGCN-DVFKARS 890

Human   895 --FPTTMALSVLVTIEMCNALNSVSENQSLLRMPPW-------------MNPWLLVAVAMSMALH 944
              |.......:::.:|:.|..||:.....:    ||             .|.:|..|:|::....
pombe   891 AVFAVVTFCILIMAVEVKNFDNSLFNLHGI----PWGEWNFRYFLHTLVENKFLAWAIALAAVSV 951

Human   945 FLILLVPPLPL-IFQVTPLSGRQWVVV 970
            |..:.:|.:.. :|:.|.: |.:|.||
pombe   952 FPTIYIPVINRDVFKHTYI-GWEWGVV 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A3	XP_011522183.1	P-type_ATPase_SERCA	5..989	CDD:319778	320/1067 (30%)
cta3	NP_595246.1	ATPase-IID_K-Na	5..1003	CDD:130586	320/1067 (30%)