Protein Alignment NPY5R and NPFR

DIOPT Version :10

• Sequence 1: XP_011530317.1
• Gene: NPY5R / 4889
• HGNCID: 7958
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Alignment Length: 444
• Identity: 111/444 - (25%)
• Similarity: 187/444 - (42%)
• Gaps: 126/444 - (28%)

Human    25 NTAATRNSDF---------PVWDD---YKSSVDDLQY-FLIGLYTFVSLLGFMGNLLILMALMKK 76
            ||.|...||.         ||..|   ...:||...| .||.:|..:.:.|.:||.|:::|:::|
  Fly    50 NTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIRK 114

Human    77 RNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFG--KVMCHIMPFLQCVSVLVSTLIL 139
            ...:|..|..|.|||.||:|:.|...|.||..:|...|.:|  .::|..:..||.:.:.|||:.:
  Fly   115 PIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISI 179

Human   140 ISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYL 204
            .:||..||.:|.:|..::|.......::|.:|.|...:.|||.|:..|:   .|...|||....|
  Fly   180 TAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELI---NTDTPALLQQIGL 241

Human   205 ------CVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMIN 263
                  |:|.|||.:.|..::|..|.|||::|::.::|::..:           .|:|:.    .
  Fly   242 QDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGI-----------YNKLKS----R 291

Human   264 LTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRS 328
            :|:...:.|..|.|:             .|.|..|:|.|:|.:
  Fly   292 ITVVAVQASSAQRKV-------------ERGRRMKRTNCLLIS---------------------- 321

Human   329 QLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHL 393
                                                               :.::|.|||:||:.
  Fly   322 ---------------------------------------------------IAIIFGVSWLPLNF 335

Human   394 FHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLI 447
            |::..|...:.:: :...:.|.|||::||.|.|.||:|||:||:..:.:...|:
  Fly   336 FNLYADMERSPVT-QSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELL 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPY5R	XP_011530317.1	7tmA_NPY5R	49..443	CDD:320520	100/402 (25%)
		TM helix 1	50..76	CDD:320520	8/25 (32%)
		TM helix 2	83..108	CDD:320520	12/24 (50%)
		TM helix 3	121..151	CDD:320520	10/29 (34%)
		TM helix 4	162..183	CDD:320520	6/20 (30%)
		TM helix 5	215..244	CDD:320520	8/28 (29%)
		TM helix 6	368..398	CDD:320520	7/29 (24%)
		TM helix 7	411..436	CDD:320520	13/24 (54%)
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	99/400 (25%)
		TM helix 1	88..114	CDD:320331	8/25 (32%)
		TM helix 2	121..146	CDD:320331	12/24 (50%)
		TM helix 3	161..191	CDD:320331	10/29 (34%)
		TM helix 4	202..223	CDD:320331	6/20 (30%)
		TM helix 5	258..287	CDD:320331	8/39 (21%)
		TM helix 6	310..340	CDD:320331	12/102 (12%)
		TM helix 7	352..377	CDD:320331	13/24 (54%)