Protein Alignment NPY5R and npy4r

DIOPT Version :10

• Sequence 1: XP_011530317.1
• Gene: NPY5R / 4889
• HGNCID: 7958
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_571515.1
• Gene: npy4r / 30717
• ZFINID: ZDB-GENE-980526-393
• Length: 377
• Species: Danio rerio
• Alignment Length: 434
• Identity: 124/434 - (28%)
• Similarity: 192/434 - (44%)
• Gaps: 106/434 - (24%)

Human    17 NKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKT 81
            |.||....:.::....|.|.|   :||...|.  |:..|..|.:||.:||:|::..:|.:|:...
Zfish    16 NSTLTHNQSNSSLFLLDVPCW---QSSTMTLT--LVLCYCLVLILGLLGNILLICIIMHQRDPPN 75

Human    82 TVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVR 146
            ..:.||.||:.|||||.:||.|||:...|:|.|:||.::|.:|||:|||||.||.|.|:.||:.|
Zfish    76 VTSILIANLSVSDILVSVFCLPFTVVYTLMDHWIFGALLCRLMPFVQCVSVTVSVLSLVLIALER 140

Human   147 YHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPS 211
            :.:|.||.....:....|..:.|||.|......|...||.|.....:...|.||...:|:|.|||
Zfish   141 HQLILHPSGWKPSVPQAYIAVLTVWLLACVTSLPFLAFHLLTSEPYSLFPAPLSQLQVCLEVWPS 205

Human   212 DSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQV 276
            ..:::|:|.||||.||..||:.:.:.:..:
Zfish   206 QDHKLAYTTSLLLFQYCCPLLLMLLCYLRI----------------------------------- 235

Human   277 KLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVP 341
                       |::..||....:..|     .|..::.|.|::
Zfish   236 -----------FLRLQRRERMLERQC-----SRNREDEHRRVM---------------------- 262

Human   342 TCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLIS 406
                                       .|:.:...|..|:..|||.|:||:.|:||.|.:..::.
Zfish   263 ---------------------------HSKRINVMLATLVAAFAVCWLPLNAFNVVADCDQEVLP 300

Human   407 NRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLI-HC 449
            ..:..|::.:||||.|.|.|:|||:|||||:..:.|:.|:: ||
Zfish   301 VCNHNLLFSLCHLLAMSSTCVNPIIYGFLNSNFRKDVASVVLHC 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPY5R	XP_011530317.1	7tmA_NPY5R	49..443	CDD:320520	111/393 (28%)
		TM helix 1	50..76	CDD:320520	9/25 (36%)
		TM helix 2	83..108	CDD:320520	14/24 (58%)
		TM helix 3	121..151	CDD:320520	16/29 (55%)
		TM helix 4	162..183	CDD:320520	6/20 (30%)
		TM helix 5	215..244	CDD:320520	10/28 (36%)
		TM helix 6	368..398	CDD:320520	11/29 (38%)
		TM helix 7	411..436	CDD:320520	14/24 (58%)
npy4r	NP_571515.1	7tm_GPCRs	43..337	CDD:475119	112/395 (28%)
		TM helix 1	45..69	CDD:320519	8/23 (35%)
		TM helix 2	78..100	CDD:320519	13/21 (62%)
		TM helix 3	116..138	CDD:320519	13/21 (62%)
		TM helix 4	159..175	CDD:320519	4/15 (27%)
		TM helix 5	210..233	CDD:320519	10/22 (45%)
		TM helix 6	268..290	CDD:320519	9/21 (43%)
		TM helix 7	305..330	CDD:320519	14/24 (58%)