Protein Alignment NPY5R and npr-7

DIOPT Version :10

• Sequence 1: XP_011530317.1
• Gene: NPY5R / 4889
• HGNCID: 7958
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_509570.3
• Gene: npr-7 / 185321
• WormBaseID: WBGene00018067
• Length: 380
• Species: Caenorhabditis elegans
• Alignment Length: 400
• Identity: 85/400 - (21%)
• Similarity: 166/400 - (41%)
• Gaps: 124/400 - (31%)

Human    55 YTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKV 119
            |..|..|..:|||.:|:.::.:|..:|..|..|.:::.:|:::..|....|..:.....|.|||.
 Worm    31 YGLVGALSLVGNLAVLLIVICRREMQTVTNIFISSVSAADLVITSFSLWATPLAYYQRVWHFGKY 95

Human   120 MCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVF 184
            ||:::..:|.:|::...|.|.::|:.||.::..|....::......:||.:|..|||:.||:
 Worm    96 MCYMVSIIQGLSLMWVPLTLAAVALDRYSLVASPFRQPMSKKTCLLIIAGIWMGGFAVLSPM--- 157

Human   185 HSLVELQETFGSALLSSRYLCVESWPSDS--YRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC 247
            ..:|:..:::|..     :.|:|||..|.  ||:.:.:|:|:::..:|||.:::.|
 Worm   158 IRMVDFVDSYGPC-----HFCLESWDHDKQHYRLFYGLSVLVIRSAIPLVLISLCH--------- 208

Human   248 GLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQ 312
                                                |..:.|...:   :||
 Worm   209 ------------------------------------WRIAVILNTQ---TKK------------- 221

Human   313 ENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRL 377
                      |.::||..:.:                :::|:          |.|:|.:::   |
 Worm   222 ----------FQTLRSASTVT----------------QSTDI----------RRKQRLQTL---L 247

Human   378 TILILVFAVSWMPLHLFHVVTDF---------NDNLISNRHFKLVYCICHLLGMMSCCLNPILYG 433
            ..::::||||.:||.|.:|:.|.         .||:   |||  ::..||...|....|||::|.
 Worm   248 LAMVVIFAVSSLPLDLSNVLQDLIVVYQVRPVPDNV---RHF--IFFFCHWTAMAGTLLNPLVYA 307

Human   434 FLNNGIKADL 443
            :.|...:..:
 Worm   308 YYNENFRRQI 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPY5R	XP_011530317.1	7tmA_NPY5R	49..443	CDD:320520	85/398 (21%)
		TM helix 1	50..76	CDD:320520	7/20 (35%)
		TM helix 2	83..108	CDD:320520	5/24 (21%)
		TM helix 3	121..151	CDD:320520	8/29 (28%)
		TM helix 4	162..183	CDD:320520	8/20 (40%)
		TM helix 5	215..244	CDD:320520	7/28 (25%)
		TM helix 6	368..398	CDD:320520	10/29 (34%)
		TM helix 7	411..436	CDD:320520	7/24 (29%)
npr-7	NP_509570.3	7tmA_NPYR-like	25..317	CDD:320331	85/398 (21%)
		TM helix 1	26..52	CDD:320331	7/20 (35%)
		TM helix 2	59..84	CDD:320331	5/24 (21%)
		TM helix 3	97..127	CDD:320331	8/29 (28%)
		TM helix 4	138..159	CDD:320331	8/23 (35%)
		TM helix 5	185..214	CDD:320331	8/73 (11%)
		TM helix 6	238..268	CDD:320331	12/32 (38%)
		TM helix 7	285..310	CDD:320331	9/26 (35%)