Protein Alignment NPY1R and NPFR

DIOPT Version :10

• Sequence 1: NP_000900.1
• Gene: NPY1R / 4886
• HGNCID: 7956
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Alignment Length: 368
• Identity: 109/368 - (29%)
• Similarity: 177/368 - (48%)
• Gaps: 55/368 - (14%)

Human    34 HLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTF 98
            |:.::|       ||.:|:.|..||..::|.::::..||...|:.|:||:.||||:.::.:|.|.
  Fly    87 HMLISM-------YGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTL 144

Human    99 VYTLMDHWVFGEA--MCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVG--- 158
            :..|..:|.:|..  :||....:|.:.|.||..|:..||.:|:|:|:.|    ..:...:||
  Fly   145 MEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYP----TRDSLQFVGAVT 205

Human   159 -IAVIWVLAVASSLPFLIYQ--VMTDEP--FQNVTLDAYKDKY-VCFDQFPSDSHRLSYTTLLLV 217
             :|.||.||:..:.|..:|:  :.||.|  .|.:.|   :|.. .|.:.:||.:.|..|:...|.
  Fly   206 ILAGIWALALLLASPLFVYKELINTDTPALLQQIGL---QDTIPYCIEDWPSRNGRFYYSIFSLC 267

Human   218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSE----TKRINIMLLSIVVAFAVCWLP 278
            :||..|:..:.:.||.||.:||.|..::.....:..|..|    .||.|.:|:||.:.|.|.|||
  Fly   268 VQYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLP 332

Human   279 LTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSR 343
            |..||...|.....: |.:..:.:.:||:..|.|.|.||:.||:||.||:::.|.....|.
  Fly   333 LNFFNLYADMERSPV-TQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCS---- 392

Human   344 DDDYETIAMSTMHT-----------------DVSKTSLKQASP 369
                :|......||                 ::||..||...|
  Fly   393 ----DTNVALNGHTTGCNVQAAARRRRKLGAELSKGELKLLGP 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPY1R	NP_000900.1	7tmA_NPY1R	41..331	CDD:320517	97/304 (32%)
		TM helix 1	42..68	CDD:320517	7/25 (28%)
		TM helix 2	75..100	CDD:320517	10/24 (42%)
		TM helix 3	113..143	CDD:320517	11/29 (38%)
		TM helix 4	154..175	CDD:320517	8/24 (33%)
		TM helix 5	208..237	CDD:320517	10/28 (36%)
		TM helix 6	256..286	CDD:320517	15/33 (45%)
		TM helix 7	299..324	CDD:320517	9/24 (38%)
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	98/310 (32%)
		TM helix 1	88..114	CDD:320331	8/32 (25%)
		TM helix 2	121..146	CDD:320331	10/24 (42%)
		TM helix 3	161..191	CDD:320331	11/29 (38%)
		TM helix 4	202..223	CDD:320331	7/20 (35%)
		TM helix 5	258..287	CDD:320331	10/28 (36%)
		TM helix 6	310..340	CDD:320331	14/29 (48%)
		TM helix 7	352..377	CDD:320331	9/24 (38%)