DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5504 and DNAJA3

DIOPT Version :9

Sequence 1:	NP_995932.1	Gene:	CG5504 / 48844	FlyBaseID:	FBgn0002174	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_005138.3	Gene:	DNAJA3 / 9093	HGNCID:	11808	Length:	480	Species:	Homo sapiens

Alignment Length:	466	Identity:	217/466 - (46%)
Similarity:	290/466 - (62%)	Gaps:	73/466 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HTTRDLLAKDYYATLGVAKNANGKDIKKAYYQLAKKYHPDTNKEDPDAGRKFQEVSEAYEVLSDE 120
            ||:..|..:|||..|||.:||:.|:||||||||||||||||||:||.|..||.:::|||||||||
Human    84 HTSAPLAKEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDE 148

  Fly   121 QKRREYDTYGQTAENIGRQGGGFPGGGAGGFGPEGFSQS--WQFRSSIDPEELFRKIFGEGNFRT 183
            .||::||.||         ..||..|.:|       ||.  |:...::||||||||||||  |.:
Human   149 VKRKQYDAYG---------SAGFDPGASG-------SQHSYWKGGPTVDPEELFRKIFGE--FSS 195

  Fly   184 NSFDDFADSKFGFGQAQEMVMDLTFAQAARGVNKDVNVNVVDQCPKCAGTKCEPGTKPGRCQYCN 248
            :||.||   :..|.|.||..|:|||.|||:||||:..||::|.|.:|.|...|||||...|.||.
Human   196 SSFGDF---QTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCG 257

  Fly   249 GTGFETVSTGPFVMRSTCRYCQGTRQHIKYPCSECEGKGRTVQRRKVTVPVPAGIENGQTVRMQV 313
            |:|.||::|||||||||||.|.|....|..||..|.|.|:..|:::|.:|||||:|:||||||.|
Human   258 GSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPV 322

  Fly   314 GSKELFVTFRVERSDYFRREGADVHTDAAISLAQAVLGGTVRVQGVYEDQWINVEPGTSSHHKIM 378
            |.:|:|:||||::|..|||:|||:|:|..||:|||:||||.|.||:||...:.:.|||.:..||.
Human   323 GKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVTIPPGTQTDQKIR 387

  Fly   379 LRGKGLKRVNAHGHGDHYVHVKITVPSAKKLDKKRLALIEAYAELEEDTPGQIHGIANRKDGSKQ 443
            :.|||:.|:|::|:||||:|:||.||  |:|..::.:||.:|||.|.|..|.::|:.....|
Human   388 MGGKGIPRINSYGYGDHYIHIKIRVP--KRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSG--- 447

  Fly   444 ATAGASEEPGAGAAAKASAAAAGSGASKPGPGAEKSEGKDQWTDNEKTKAKEGGGSGSGQGDGGG 508
               |::.:..||:.|:..|                  |:|:
Human   448 ---GSTMDSSAGSKARREA------------------GEDE------------------------ 467

  Fly   509 GGFISKIKSMF 519
            .||:||:|.||
Human   468 EGFLSKLKKMF 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5504	NP_995932.1	DnaJ	63..437	CDD:223560	199/375 (53%)
		DnaJ	65..127	CDD:278647	43/61 (70%)
		DnaJ_zf	227..287	CDD:199908	33/59 (56%)
		DnaJ_C	288..409	CDD:199909	66/120 (55%)
DNAJA3	NP_005138.3	DnaJ	90..480	CDD:223560	214/460 (47%)
		DnaJ	93..155	CDD:278647	43/61 (70%)
		DnaJ_C	207..416	CDD:199909	117/210 (56%)
		DnaJ_zf	236..296	CDD:199908	33/59 (56%)
		CXXCXGXG motif	236..243		3/6 (50%)
		CXXCXGXG motif	253..260		4/6 (67%)
		CXXCXGXG motif	275..282		4/6 (67%)
		CXXCXGXG motif	289..296		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..471		9/75 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147826
Domainoid	1	1.000	257	1.000	Domainoid score	I2032
eggNOG	1	0.900	-	-		E2759_KOG0715
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36170
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1874
Isobase	1	0.950	-	0	Normalized mean entropy	S1730
OMA	1	1.010	-	-		QHG53632
OrthoDB	1	1.010	-	-		D436402at33208
OrthoFinder	1	1.000	-	-		FOG0001676
OrthoInspector	1	1.000	-	-		oto89395
orthoMCL	1	0.900	-	-		OOG6_100469
Panther	1	1.100	-	-	LDO	PTHR44145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R701
SonicParanoid	1	1.000	-	-		X2075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750