DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5504 and Dnaja3

DIOPT Version :9

Sequence 1:	NP_995932.1	Gene:	CG5504 / 48844	FlyBaseID:	FBgn0002174	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001033684.2	Gene:	Dnaja3 / 360481	RGDID:	1306527	Length:	480	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	228/535 - (42%)
Similarity:	305/535 - (57%)	Gaps:	116/535 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CKKLFVFRQLPAVRRCLAAAAFST----PRA-------------TSYRILSSAGSGSTRADAPQV 52
            |:||           |::|...|.    |||             .|:..:.:|.
  Rat    40 CRKL-----------CVSAFGLSMGAHGPRALLTLRPGVRLTGTKSFPFVCTAS----------- 82

  Fly    53 RRLHTTRDLLAKDYYATLGVAKNANGKDIKKAYYQLAKKYHPDTNKEDPDAGRKFQEVSEAYEVL 117
              .||:..|...|||..|||.:||:.||||||||||||||||||||:||.|..||.:::||||||
  Rat    83 --FHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVL 145

  Fly   118 SDEQKRREYDTYGQTAENIGRQGGGF-PGGGAGGFGPEGFSQSWQFRSSIDPEELFRKIFGEGNF 181
            |||.||::||.||         ..|| ||..:.|   :|:   |:...|:||||||||||||  |
  Rat   146 SDEVKRKQYDAYG---------SAGFDPGASSSG---QGY---WRGGPSVDPEELFRKIFGE--F 193

  Fly   182 RTNSFDDFADSKFGFGQAQEMVMDLTFAQAARGVNKDVNVNVVDQCPKCAGTKCEPGTKPGRCQY 246
            .::.|.||.:.   |.|.||.:|:|||.|||:||||:..||::|.|.:|.|...|||||...|.|
  Rat   194 SSSPFGDFQNV---FDQPQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHY 255

  Fly   247 CNGTGFETVSTGPFVMRSTCRYCQGTRQHIKYPCSECEGKGRTVQRRKVTVPVPAGIENGQTVRM 311
            |:|:|.||::|||||||||||.|.|....|..||..|.|.|:..|:::||||||||:|:||||||
  Rat   256 CSGSGMETINTGPFVMRSTCRRCGGRGSIITNPCVVCRGAGQAKQKKRVTVPVPAGVEDGQTVRM 320

  Fly   312 QVGSKELFVTFRVERSDYFRREGADVHTDAAISLAQAVLGGTVRVQGVYEDQWINVEPGTSSHHK 376
            .||.:|:||||||::|..|||:|||:|:|..||:|||:||||.:.||:||...:.:..|..:..|
  Rat   321 PVGKREIFVTFRVQKSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQK 385

  Fly   377 IMLRGKGLKRVNAHGHGDHYVHVKITVPSAKKLDKKRLALIEAYAELEEDTPGQIHGIANRKDGS 441
            |.|.|||:.|:|::|:||||:|:||.||  |:|..::..||.:|||.|.|..|.::|:.:...|.
  Rat   386 IRLTGKGIPRINSYGYGDHYIHIKIRVP--KRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGG 448

  Fly   442 K--QATAGASEEPGAGAAAKASAAAAGSGASKPGPGAEKSEGKDQWTDNEKTKAKEGGGSGSGQG 504
            :  .::.|:.:...||                              .|||
  Rat   449 RTMDSSTGSKDRREAG------------------------------EDNE--------------- 468

  Fly   505 DGGGGGFISKIKSMF 519
                 ||:||:|.:|
  Rat   469 -----GFLSKLKKIF 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5504	NP_995932.1	DnaJ	63..437	CDD:223560	201/374 (54%)
		DnaJ	65..127	CDD:278647	44/61 (72%)
		DnaJ_zf	227..287	CDD:199908	33/59 (56%)
		DnaJ_C	288..409	CDD:199909	67/120 (56%)
Dnaja3	NP_001033684.2	DnaJ	90..480	CDD:223560	214/461 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341683
Domainoid	1	1.000	258	1.000	Domainoid score	I1939
eggNOG	1	0.900	-	-		E2759_KOG0715
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36170
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1787
OMA	1	1.010	-	-		QHG53632
OrthoDB	1	1.010	-	-		D436402at33208
OrthoFinder	1	1.000	-	-		FOG0001676
OrthoInspector	1	1.000	-	-		oto96521
orthoMCL	1	0.900	-	-		OOG6_100469
Panther	1	1.100	-	-	LDO	PTHR44145
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770