DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5504 and dnaja3a

DIOPT Version :9

Sequence 1:	NP_995932.1	Gene:	CG5504 / 48844	FlyBaseID:	FBgn0002174	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_005168528.1	Gene:	dnaja3a / 335894	ZFINID:	ZDB-GENE-030131-7837	Length:	475	Species:	Danio rerio

Alignment Length:	537	Identity:	235/537 - (43%)
Similarity:	303/537 - (56%)	Gaps:	109/537 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RCLAAAAFST---------PRAT-SYR----------------ILSSAG-----SGSTRADAPQV 52
            |.::||..|:         |||. :||                :...||     ||.|...:..|
Zfish    11 RWISAAVSSSHSRACSPFIPRADGAYRGFKSLSGRQMWTTRGGLSGGAGAAVTLSGMTAIGSSHV 75

  Fly    53 ---RRLHTTRDLLAKDYYATLGVAKNANGKDIKKAYYQLAKKYHPDTNKEDPDAGRKFQEVSEAY 114
               ...||:.....:|:|..|||.::|..|:|||||||:|||||||||||||.|..||.:::|||
Zfish    76 VCKMSFHTSAPSRKQDFYQILGVPRSATQKEIKKAYYQMAKKYHPDTNKEDPQAKEKFAQLAEAY 140

  Fly   115 EVLSDEQKRREYDTYGQTAENIGRQGGGFPGGGAGGFGPEGFSQSWQFRSSIDPEELFRKIFGEG 179
            ||||||.||::|||||         ..||..|.||.    |..|.|...:||||||||||||||
Zfish   141 EVLSDEVKRKQYDTYG---------SAGFDAGRAGA----GHQQYWGGGTSIDPEELFRKIFGE- 191

  Fly   180 NFRTNSFDDFADSKFGFGQAQEMVMDLTFAQAARGVNKDVNVNVVDQCPKCAGTKCEPGTKPGRC 244
               .:....|.|....|.|.||.||:|||||||:||||::.||:...|.:|.|...|||:|...|
Zfish   192 ---FSGAQGFGDFNAIFNQPQEYVMELTFAQAAKGVNKEITVNIEGTCQRCDGRGHEPGSKVQHC 253

  Fly   245 QYCNGTGFETVSTGPFVMRSTCRYCQGTRQHIKYPCSECEGKGRTVQRRKVTVPVPAGIENGQTV 309
            ..|||||.|||:|||||||||||.|.|....|..||..|.|.|:|.||:.||||||||||:||||
Zfish   254 GNCNGTGMETVNTGPFVMRSTCRRCGGRGSVITSPCIACRGTGQTKQRKTVTVPVPAGIEDGQTV 318

  Fly   310 RMQVGSKELFVTFRVERSDYFRREGADVHTDAAISLAQAVLGGTVRVQGVYEDQWINVEPGTSSH 374
            ||.||.||:|:||:|::|..|||:|||:|:|..||:|||:||||:|.||:||...:::..||.:.
Zfish   319 RMPVGKKEIFITFKVQKSPIFRRDGADIHSDVMISVAQAILGGTIRAQGLYETINLSIPVGTQTD 383

  Fly   375 HKIMLRGKGLKRVNAHGHGDHYVHVKITVPSAKKLDKKRLALIEAYAELEEDTPGQIHGIANRKD 439
            .:|.|.|||:.||:.:|:||||||:||.:|  |.|..::.||:.:|||.|.|..|.::|:
Zfish   384 QRIRLSGKGIPRVSGYGYGDHYVHIKIKIP--KMLTDRQRALMMSYAEDESDVEGTVNGV----- 441

  Fly   440 GSKQATAGASEEPGAGAAAKASAAAAGSGASKPGPG-AEKSEGKDQWTDNEKTKAKEGGGSGSGQ 503
                                 ::..||.|:::.|.| .||.|
Zfish   442 ---------------------TSTTAGGGSNQTGTGHTEKDE----------------------- 462

  Fly   504 GDGGGGGFISKIKSMFN 520
                  |..||:|.||:
Zfish   463 ------GIFSKLKKMFS 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5504	NP_995932.1	DnaJ	63..437	CDD:223560	204/373 (55%)
		DnaJ	65..127	CDD:278647	41/61 (67%)
		DnaJ_zf	227..287	CDD:199908	34/59 (58%)
		DnaJ_C	288..409	CDD:199909	70/120 (58%)
dnaja3a	XP_005168528.1	DnaJ	89..474	CDD:223560	218/459 (47%)
		DnaJ	91..153	CDD:278647	41/61 (67%)
		DnaJ_C	207..416	CDD:199909	123/210 (59%)
		DnaJ_zf	236..296	CDD:199908	34/59 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581698
Domainoid	1	1.000	260	1.000	Domainoid score	I1936
eggNOG	1	0.900	-	-		E2759_KOG0715
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36170
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1831
OMA	1	1.010	-	-		QHG53632
OrthoDB	1	1.010	-	-		D436402at33208
OrthoFinder	1	1.000	-	-		FOG0001676
OrthoInspector	1	1.000	-	-		otm26102
orthoMCL	1	0.900	-	-		OOG6_100469
Panther	1	1.100	-	-	LDO	PTHR44145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R701
SonicParanoid	1	1.000	-	-		X2075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800