DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5504 and mdj1

DIOPT Version :9

Sequence 1:	NP_995932.1	Gene:	CG5504 / 48844	FlyBaseID:	FBgn0002174	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_587824.1	Gene:	mdj1 / 2539501	PomBaseID:	SPCC4G3.14	Length:	528	Species:	Schizosaccharomyces pombe

Alignment Length:	524	Identity:	164/524 - (31%)
Similarity:	240/524 - (45%)	Gaps:	83/524 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SCKKLFVFRQLPAVR-------RCLAAAAFSTPRATSYRILSSAGSGSTRADAPQVRRLHTTRDL 61
            ||.|   ||.:...|       ||.|...||.                      ..|..|.||.:
pombe    42 SCTK---FRNVAIQRNAKREFSRCAALKNFSY----------------------HARCFHATRAV 81

  Fly    62 L-AKDYYATLGVAKNANGKDIKKAYYQLAKKYHPDTNKEDPDAGRKFQEVSEAYEVLSDEQKRRE 125
            . ..|.|.||||:|:|:..:||.|||:|||:||||.| .|..|..||.|:.:|||||.|.:|::.
pombe    82 WEMTDPYKTLGVSKSASASEIKSAYYKLAKQYHPDAN-PDKAAQDKFVEIKQAYEVLQDPKKKKA 145

  Fly   126 YDTYGQTAENIGRQGGGFPGGGAGGFGPEGFSQSWQFRSSIDPEELFRKIFGEGN-----FRTNS 185
            :||||..|    .:.|.|.||...|| ..||:.:..|.|.. |...|..:||..:     .|..|
pombe   146 FDTYGAGA----FKNGEFTGGDFEGF-QNGFAGASSFSSGF-PGFNFEDLFGFSSRGPQARRNTS 204

  Fly   186 FDDFADSKFGFGQAQEMVMDLTFAQAARGVNKDVNVNVVDQCPKCAGTKCEPGTKPGRCQYCNGT 250
            ||.|.      |:..|..:.:.|.:|.||..||::.:|...|..|.|:..:||:....|..|.||
pombe   205 FDVFV------GEDIEASITIDFMEAVRGAKKDLSYSVSSTCSSCHGSGLQPGSHKSTCFACKGT 263

  Fly   251 GFETVSTGP-FVMRSTCRYCQGTRQHI--KYPCSECEGKGRTVQRRKVTVPVPAGIENGQTVR-M 311
            |.......| |.|::||..|.||...|  ...|..|.|.|...:|:.|::.:|.||::...:| |
pombe   264 GQRLHFIPPSFHMQTTCDSCGGTGTTIPPNSACRSCMGSGTVRERKTVSIDIPPGIDDNTVLRVM 328

  Fly   312 QVGSK---------------ELFVTFRVERSDYFRREGADVHTDAAISLAQAVLGGTVRVQGVYE 361
            ..|:.               :||.|..|.:..:|.|||.:|..:|.|.:..|.||||:||..:..
pombe   329 GAGNDASTAKGGPNAKSRPGDLFATIHVRKHPFFVREGTNVTYNAKIPMTTAALGGTLRVPTLTG 393

  Fly   362 DQWINVEPGTSSHHKIMLRGKGLKRVNAHGHGDHYVHVKITVPSAKKLDKKRLALIEAYAELEED 426
            :..:.|.||||:..:|.:.|||:::||...:|:.||:.::|:|  |.|.....:|:|..|:...|
pombe   394 NVDLRVSPGTSTGDRITMAGKGIRKVNTSRYGNFYVNFEVTIP--KILSPHERSLLEQLADALND 456

  Fly   427 --------TPGQIHGIANRKDGSKQATAGASEEPGAGAAAKASAAAAG---SGASKPGPGAEKSE 480
                    :|...:...:....|.:.:.|.|.||..|...|...:..|   ....:..|..:::.
pombe   457 STARRTQSSPSGTNSSTSTSSTSSKHSTGISTEPTTGEENKQDGSVGGFFKRAFRRLHPDEDQNP 521

  Fly   481 GKDQ 484
            .||:
pombe   522 KKDE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5504	NP_995932.1	DnaJ	63..437	CDD:223560	138/405 (34%)
		DnaJ	65..127	CDD:278647	33/61 (54%)
		DnaJ_zf	227..287	CDD:199908	22/62 (35%)
		DnaJ_C	288..409	CDD:199909	43/136 (32%)
mdj1	NP_587824.1	DnaJ	82..457	CDD:223560	136/389 (35%)
		DnaJ	86..147	CDD:278647	33/61 (54%)
		DnaJ_zf	243..303	CDD:199908	21/59 (36%)
		DnaJ_C	304..439	CDD:199909	43/136 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	126	1.000	Domainoid score	I1376
eggNOG	1	0.900	-	-		E2759_KOG0715
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36170
Inparanoid	1	1.050	217	1.000	Inparanoid score	I925
OMA	1	1.010	-	-		QHG53632
OrthoFinder	1	1.000	-	-		FOG0001676
OrthoInspector	1	1.000	-	-		oto100969
orthoMCL	1	0.900	-	-		OOG6_100469
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R701
SonicParanoid	1	1.000	-	-		X2075
TreeFam	1	0.960	-	-
	13	12.760