DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Catsup and Slc39a7

DIOPT Version :9

Sequence 1:	NP_524931.1	Gene:	Catsup / 48805	FlyBaseID:	FBgn0002022	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	XP_038954431.1	Gene:	Slc39a7 / 294281	RGDID:	1593280	Length:	504	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	239/520 - (45%)
Similarity:	301/520 - (57%)	Gaps:	115/520 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LALVVILGAVLFSLPALCAGQGNPSFKYSREANENFDPQKAPRAEHHHHHDHDHD---HGHHH-H 79
            :|:.::..|.|..|.|...|.|:    ..|:..|:|         |.|.|.|.|:   |||.| |
  Rat    11 VAVGLLTWAALGLLVAGHEGHGD----LHRDVEEDF---------HGHSHGHSHEDFHHGHSHGH 62

  Fly    80 GHDHD---HDHDHGHDHGHH----HHGHDHDHDHDHGHHH-HGHDERHTK------AKPDLDMST 130
            ||.|:   |.|.|.|||||.    ||||.|.|.||..||. |||....::      .|..||..|
  Rat    63 GHTHESIWHGHAHSHDHGHSREDVHHGHSHGHSHDSLHHRGHGHSHGASREAGAPGIKHHLDTVT 127

  Fly   131 IWLHSIGSTLLISAAPFVLLYIIPLD-NSEAMKPRLKVLLAFASGGLLGDAFLHLIPHATHPHSH 194
            :|.:::|:|:|||||||.:|::||:: ||...:..|::||:||||||||||||||||||..||||
  Rat   128 LWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHALEPHSH 192

  Fly   195 ---GEHGHDHGHDHHHHHDGEEHEHGHSHDMSIGLWVLGGIIAFLSVEKLVRILKGGHG-----G 251
               .:.||.|.|.            |....:|:|||||.||:|||.|||.||.:|||||     |
  Rat   193 DTPAQPGHGHSHS------------GQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHAHAHG 245

  Fly   252 HGHSHG------------------------------------------------APKPKPVPAKK 268
            ||||||                                                :|...|...|.
  Rat   246 HGHSHGDSHAHGHSHAHGDRHGEPTPIACYTTRSGSSAGAGHGKSSVPHSDQLLSPSECPSKGKP 310

  Fly   269 KSSDKEDSG------DGDKPAKPAKIKSKKPEAEPEG-EVEISGYLNLAADFAHNFTDGLAIGAS 326
            .|.|::::|      .||...:...:|.:.||.|..| ::.:|||||||||.|||||||||||||
  Rat   311 SSEDEKEAGGLRKRRGGDTGPRDGPLKPQNPEEEKTGSDLRVSGYLNLAADLAHNFTDGLAIGAS 375

  Fly   327 YLAGNSIGIVTTITILLHEVPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGGG 391
            :..|..:||:||:|:||||||||:||||||::||||:::||.|||:||:|||||||.|||..||.
  Rat   376 FRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAIGALAGTACALLTEGGA 440

  Fly   392 DGS------AP-WVLPFTAGGFIYIATVSVLPELLEESTKLKQSLKEIFALLTGVALMIVIAKFE 449
            .||      .| ||||||||||||:||||||||||.|::.| |||.|:..||.|||:|::||..|
  Rat   441 VGSEVAGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPL-QSLLEVLGLLGGVAMMVLIAHLE 504

Fly 450 449
Rat 505 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Catsup	NP_524931.1	Zip	129..446	CDD:280666	189/387 (49%)
Slc39a7	XP_038954431.1	Zip	126..481	CDD:396884	178/366 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353658
Domainoid	1	1.000	342	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	412	1.000	Inparanoid score	I1799
OMA	1	1.010	-	-		QHG57827
OrthoDB	1	1.010	-	-		D548499at33208
OrthoFinder	1	1.000	-	-		FOG0001345
OrthoInspector	1	1.000	-	-		oto98151
orthoMCL	1	0.900	-	-		OOG6_103840
Panther	1	1.100	-	-	LDO	PTHR16950
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2900
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770