Protein Alignment Catsup and SLC39A6

DIOPT Version :9

• Sequence 1: NP_524931.1
• Gene: Catsup / 48805
• FlyBaseID: FBgn0002022
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_036451.4
• Gene: SLC39A6 / 25800
• HGNCID: 18607
• Length: 755
• Species: Homo sapiens
• Alignment Length: 708
• Identity: 149/708 - (21%)
• Similarity: 217/708 - (30%)
• Gaps: 322/708 - (45%)

  Fly    38 GQGNP-SFKYSREANENFDPQKAPRAEHHHHHDHDHDHGHH-----HHGHDHDHDHDHGHDHGHH 96
            |:.|. |.:..|:..:|....|..|...||.|||..||.||     |..|:|..:|:|..||.||
Human    65 GENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHDHH 129

  Fly    97 -HHGH-------------DHDHD---------HDHGHHHHGHD---------------------- 116
             ||.|             |||.|         ...|.|...|.
Human   130 SHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEVTSTVYNT 194

  Fly   117 -----------------------------------------------------------ERHTKA 122
                                                                       .|:|..
Human   195 VSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFMYSRNTNE 259

  Fly   123 KP-----------------------------------DLDMSTIWLHS----------------- 135
            .|                                   .:|..:..:|:
Human   260 NPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIHTSEKKAEIPPKTYSLQIA 324

  Fly   136 -IGSTLLISAAPFVLL---YIIPLDNSEAMKPRLKVLLAFASGGLLGDAFLHLIPHATHPHSHGE 196
             :|..:.||...|:.|   .::||.|....|..|..|:|.|.|.|.|||||||:     ||||..
Human   325 WVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDAFLHLL-----PHSHAS 384

  Fly   197 HGHDHGHDH----------HHHHDGEEHEHGHSHDMS-IGLWVLGGIIAFLSVEKLVRILKGGHG 250
            |.|.|.|:.          ..|...:..|.....|.: .||..|||:.....||.::.::
Human   385 HHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVEHVLTLI----- 444

  Fly   251 GHGHSHGAPKPKPVPAKKKSSDKEDSGDGDKPAK------------------------------- 284
                       |....|||.:.|:...|.|...|
Human   445 -----------KQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTNEEKVDTDDRTEGYLRADS 498

  Fly   285 --PAKIKSKKPEAEPEGEVEI-------------------------------------------- 303
              |:...|::|....|.||.|
Human   499 QEPSHFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHH 563

  Fly   304 --------------------------SGYLNLA-----ADFAHNFTDGLAIGASYLAGNSIGIVT 337
                                      :|...||     .|..|||:|||||||::..|.|.|:.|
Human   564 ILHHHHHQNHHPHSHSQRYSREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLST 628

  Fly   338 TITILLHEVPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGGGDGSAPWVLPFT 402
            ::.:..||:|||:||||:|:|:|.:.::|:|...::|:.|..|.|..:......:..:.|:...|
Human   629 SVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALT 693

  Fly   403 AGGFIYIATVSVLPELLEESTK-----------LKQSLKEIFALLTGVALMIVIAKFE 449
            ||.|:|:|.|.::||:|.....           |:.:     .:|.|..:|::|:.||
Human   694 AGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNA-----GMLLGFGIMLLISIFE 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Catsup	NP_524931.1	Zip	129..446	CDD:280666	107/467 (23%)
SLC39A6	NP_036451.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..186		26/90 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..246		0/43 (0%)
		Zip	323..742	CDD:308248	106/444 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820