DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Catsup and Slc39a7

DIOPT Version :9

Sequence 1:	NP_524931.1	Gene:	Catsup / 48805	FlyBaseID:	FBgn0002022	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001071177.1	Gene:	Slc39a7 / 14977	MGIID:	95909	Length:	476	Species:	Mus musculus

Alignment Length:	494	Identity:	241/494 - (48%)
Similarity:	300/494 - (60%)	Gaps:	91/494 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LALVVILGAVLFSLPALCAGQGNPSFKYSREANENFDPQKAPRAEHHHHHDHDHDHGHH--HHGH 81
            :|:.::..|.|..|.|...|.|:    ..::..|:|.......:....||.|.|.|.|.  ||||
Mouse    11 VAVGLLTWAALGLLVAGHEGHGD----LHKDVEEDFHGHSHGHSHEDFHHGHSHGHSHEDFHHGH 71

  Fly    82 DHDHD-----HDHGHDHGHH----HHGHDHDHDHD---HGHHHHGHDE------RHTKA---KPD 125
            .|.|:     |.|.|||||.    ||||.|.|.||   ||.|.|.|.|      |...|   |..
Mouse    72 GHTHESIWHGHAHSHDHGHSREELHHGHSHGHSHDSLHHGGHGHAHREHSHGTSREAGAPGIKHH 136

  Fly   126 LDMSTIWLHSIGSTLLISAAPFVLLYIIPLD-NSEAMKPRLKVLLAFASGGLLGDAFLHLIPHAT 189
            ||..|:|.:::|:|:|||||||.:|::||:: ||...:..|::||:||||||||||||||||||.
Mouse   137 LDTVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHAL 201

  Fly   190 HPHSHGEHGHDHGHDHHHHHDGEEHEHGHSHD-----MSIGLWVLGGIIAFLSVEKLVRILKGGH 249
            .|||              ||..|:..|||||.     :|:|||||.||:|||.|||.||.:||||
Mouse   202 EPHS--------------HHAPEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGH 252

  Fly   250 G---GHG--------HSHG-----APKPKPVPAKKKSSDKE----------DSGDGDKPAKPAKI 288
            |   |||        |:||     :.|.||    ....:||          ::|..|.|.||
Mouse   253 GHSHGHGDRHAHGDSHTHGDRHECSSKEKP----STEEEKEVGGLRKRRGGNTGPRDGPVKP--- 310

  Fly   289 KSKKPEAEPEG-EVEISGYLNLAADFAHNFTDGLAIGASYLAGNSIGIVTTITILLHEVPHEIGD 352
              :.||.|..| ::.:|||||||||.|||||||||||||:..|..:||:||:|:||||||||:||
Mouse   311 --QSPEEEKAGSDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGD 373

  Fly   353 FAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGG------GDGSAP-WVLPFTAGGFIYIA 410
            ||||::||||:::||.||||||:|||||||.|||..||      ..|:.| ||||||||||||:|
Mouse   374 FAILVQSGCSKKQAMRLQLVTAIGALAGTACALLTEGGAVDSDVAGGAGPGWVLPFTAGGFIYVA 438

  Fly   411 TVSVLPELLEESTKLKQSLKEIFALLTGVALMIVIAKFE 449
            |||||||||.|::.| |||.|:..||.|||:|::||..|
Mouse   439 TVSVLPELLREASPL-QSLLEVLGLLGGVAMMVLIAHLE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Catsup	NP_524931.1	Zip	129..446	CDD:280666	191/356 (54%)
Slc39a7	NP_001071177.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..131		36/95 (38%)
		Zip	140..453	CDD:280666	180/335 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..320		24/79 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849980
Domainoid	1	1.000	337	1.000	Domainoid score	I1112
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	405	1.000	Inparanoid score	I1886
Isobase	1	0.950	-	0	Normalized mean entropy	S1421
OMA	1	1.010	-	-		QHG57827
OrthoDB	1	1.010	-	-		D548499at33208
OrthoFinder	1	1.000	-	-		FOG0001345
OrthoInspector	1	1.000	-	-		oto94643
orthoMCL	1	0.900	-	-		OOG6_103840
Panther	1	1.100	-	-	LDO	PTHR16950
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1954
SonicParanoid	1	1.000	-	-		X2900
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750