DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Catsup and Slc39a6

DIOPT Version :9

Sequence 1:	NP_524931.1	Gene:	Catsup / 48805	FlyBaseID:	FBgn0002022	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_631882.2	Gene:	Slc39a6 / 106957	MGIID:	2147279	Length:	765	Species:	Mus musculus

Alignment Length:	771	Identity:	160/771 - (20%)
Similarity:	240/771 - (31%)	Gaps:	359/771 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LALVVILGAVLFSLPALCAGQGNPSFKYSRE-ANENFDP----QKAPRAEHHH------------ 66
            |::::||...|:....|...|...:|..:.| .|.|::|    ..|...:.||
Mouse     5 LSVIMILTFALWVTSPLHELQSTAAFSQTTEKINSNWEPGVNVDLAVTMQRHHLQQLFYRYGEND 69

  Fly    67 ------------------------HHDHDHDHGHHHHG-HDHDHDHDHGHDHGHHHHGHDHDHDH 106
                                    ||||:|...|.||. |:|..||:|..||.||   .||:|..
Mouse    70 SLSVEGFRKLLQNIGIDKIKRVHIHHDHEHHADHEHHSDHEHHSDHEHHSDHEHH---SDHEHHS 131

  Fly   107 DHGHHHHGHDERHTKAK--------PDLD------------------------------------ 127
            ||.||.|   ..||.|.        ||||
Mouse   132 DHEHHSH---RSHTVAGKNNRKAFCPDLDSDNSGKNPRTSLGKGSRPAEHMNGRRNIKESASSSE 193

  Fly   128 ---------------MSTI---------------------------------------------- 131
                           :.||
Mouse   194 VTSAVYNAVSEGTRFVETIETPKPGRRTKDVNPSTPPSITEKSRVGRLSRLARKKSNESVSEPRK 258

  Fly   132 ----------------------------------------------------------------- 131

Mouse   259 SFMYSRNTNDNIQECFNTTKLLTSHGMSIQALLNATEFNYLCPAIINQIDARACLIHTASEKKAE 323

  Fly   132 -----------WLHSIGSTLLISAAPFVLL---YIIPLDNSEAMKPRLKVLLAFASGGLLGDAFL 182
                       ||   |..:.||...|:.|   .::||.|....|..|..|:|.|.|.|.|||.|
Mouse   324 IPPKTYSLQIAWL---GGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDALL 385

  Fly   183 HLIPHATHPHSHGEHGHDHGHDH----------HHHHDGEEHEHGHSHDMS-IGLWVLGGIIAFL 236
            ||:     ||||..|.|.|.|:.          ..|...:..|.....|.: .||..|||:....
Mouse   386 HLL-----PHSHASHQHSHSHEEPAMEMKRGPLFSHLSAQNIEESSYFDSTWKGLTALGGLYFMF 445

  Fly   237 SVEKLVRILKGGHGGHGHSHGAPK-PKPVPAKKK--------SSDKEDSGDGDKP--------AK 284
            .||.::.::|........:...|: .:.|.:||:        ||::|....|::|        .:
Mouse   446 LVEHVLTLIKQFKDKKKKNQKKPENDEDVESKKQLSKYDSQLSSNEEKVDPGERPESYLRADSQE 510

  Fly   285 PAKIKSKKP--------------------EAEPEG------------------------------ 299
            |:...|::|                    |..|.|
Mouse   511 PSPFDSQQPTMLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHIL 575

  Fly   300 --------------------EVEISGYLNLA-----ADFAHNFTDGLAIGASYLAGNSIGIVTTI 339
                                |::.:|...||     .|..|||:|||||||::..|.|.|:.|::
Mouse   576 HHHHHQNHHPHSHSQRYSREELKDAGIATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSV 640

  Fly   340 TILLHEVPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGGGDGSAPWVLPFTAG 404
            .:..||:|||:||||:|:|:|.:.::|:|...::|:.|..|.|..:......:..:.|:...|||
Mouse   641 AVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAG 705

  Fly   405 GFIYIATVSVLPELLEESTK-----------LKQSLKEIFALLTGVALMIVIAKFE 449
            .|:|:|.|.::||:|.....           |:.:     .:|.|..:|::|:.||
Mouse   706 LFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNA-----GILLGFGIMLLISIFE 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Catsup	NP_524931.1	Zip	129..446	CDD:280666	111/555 (20%)
Slc39a6	NP_631882.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..196		30/105 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..257		2/47 (4%)
		Zip	333..752	CDD:280666	109/431 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..519		11/60 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820