DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Catsup and slc39a4

DIOPT Version :9

Sequence 1:	NP_524931.1	Gene:	Catsup / 48805	FlyBaseID:	FBgn0002022	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	XP_031760368.1	Gene:	slc39a4 / 100485091	XenbaseID:	XB-GENE-6049378	Length:	681	Species:	Xenopus tropicalis

Alignment Length:	450	Identity:	118/450 - (26%)
Similarity:	187/450 - (41%)	Gaps:	92/450 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RAEHHHHHDHDHDHGHHHHGHDH--------DHDHDHGHDHGHH--H--------------HGHD 101
            |.|.|..||     |..|.||..        .|......|:..|  |              ||.|
Frog   258 REEEHGDHD-----GEDHEGHGDAQEMPDPMAHRRRLAQDNAPHTRHWVETCFSPRELFAIHGID 317

  Fly   102 HD-----HDHDH----------------GHHHHGHDERHTKAKPDLDMSTIWLHSIGSTLLISAA 145
            .|     ....|                |....|:.|:       |.::..:::...:||::|..
Frog   318 PDLGISPEQFPHVGTSLIQLQVSKVCARGQEPGGNQEQ-------LSIAEKYIYGTIATLVVSLC 375

  Fly   146 PFVLLYIIPLDN-SEAMKPRLKVLLAFASGGLLGDAFLHLIPHATHPHSHGEHGHDHGHDHHHHH 209
            ..:.:.|:...: :.|.:..::..::.|.|.|.|||.|||||...     |.|||.....|.|.
Frog   376 ALLGISILLCTSCTTAYQYIIQFFVSLAVGSLTGDAVLHLIPQLL-----GLHGHSDPQGHSHQ- 434

  Fly   210 DGEEHEHGHSHDMSIGLW----VLGGIIAFLSVEKLVRIL-----KGGHGGHGH-SHGAPKPKPV 264
              ||.:..|       :|    |||||..|..:|||..||     :.....||| .||.......
Frog   435 --EEEDRSH-------IWKLLAVLGGIYLFFLMEKLFSILMISGEEAEGANHGHCDHGLSLQNYH 490

  Fly   265 PAKKKSSDKEDSGDGDKP-AKPAKIKSKKPEAEPEGEVEISGYLNLAADFAHNFTDGLAIGASYL 328
            ..|::..:::.....|.. |...:..|.:.:|:.. |:::..|:....|..|||.|||||||::.
Frog   491 QDKERRKEQKSESQADLVCATDVEFGSGRQKAKSR-ELQMIPYMITIGDAIHNFADGLAIGAAFS 554

  Fly   329 AGNSIGIVTTITILLHEVPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGGGDG 393
            .....|:.|::.:|.||:|||:||||.|:.:|...|.|:||...:||.|..|..:: |.....:.
Frog   555 TSWKTGLATSLAVLCHELPHELGDFAALLHAGLRVRWALLLNFSSALTAFIGLYIS-LSISADEA 618

  Fly   394 SAPWVLPFTAGGFIYIATVSVLPELLEESTKLKQSLKEIF----ALLTGVALMIVIAKFE 449
            ...|:.....|.|:|:|...:||.::  :.||.:.....|    .:|.|..::::::.:|
Frog   619 VQQWIFTVATGLFLYVALADMLPAMM--NVKLHRPWILFFLHNLGILLGWVILLILSLYE 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Catsup	NP_524931.1	Zip	129..446	CDD:280666	95/332 (29%)
slc39a4	XP_031760368.1	ZIP4_domain	79..>153	CDD:408101
slc39a4	XP_031760368.1	Zip	363..672	CDD:396884	95/327 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010