Protein Alignment ATP2A2 and PMR1

DIOPT Version :10

• Sequence 1: NP_733765.1
• Gene: ATP2A2 / 488
• HGNCID: 812
• Length: 1042
• Species: Homo sapiens
• Sequence 2: NP_011348.1
• Gene: PMR1 / 852709
• SGDID: S000003135
• Length: 950
• Species: Saccharomyces cerevisiae
• Alignment Length: 1016
• Identity: 318/1016 - (31%)
• Similarity: 513/1016 - (50%)
• Gaps: 151/1016 - (14%)

Human     6 TKTVEEVLGHFGVNESTGL-SLEQVKKLKERWGSNELPAEEGKTLLELVIEQF-EDLLVRILLLA 68
            |.:|:|.|.....:::.|| |..:....:..:|.||:..|:.::|.:..:..| ||.::.:|:.:
Yeast    40 TLSVDEALEKLDTDKNGGLRSSNEANNRRSLYGPNEITVEDDESLFKKFLSNFIEDRMILLLIGS 104

Human    69 ACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQD 133
            |.:|..:...::......|.   |:::       .||..||..:|.::|||.:..|....:.|..
Yeast   105 AVVSLFMGNIDDAVSITLAI---FIVV-------TVGFVQEYRSEKSLEALNKLVPAECHLMRCG 159

Human   134 RKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPV---- 194
            ::|  .:.|..:||||:|...:||::|||||:  |::..|.:|:|.||||:..|.|.:..:
Yeast   160 QES--HVLASTLVPGDLVHFRIGDRIPADIRI--IEAIDLSIDESNLTGENEPVHKTSQTIEKSS 220

Human   195 ----PDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDE 255
                |:......::..:.:.||.:..|...|:||.||.||..|.:.:.|...|:.:||||..:|:
Yeast   221 FNDQPNSIVPISERSCIAYMGTLVKEGHGKGIVVGTGTNTSFGAVFEMMNNIEKPKTPLQLTMDK 285

Human   256 FGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLA 320
            .|:.||.|..::...:.::.|      :.|.||:.    .|:|:|:|||||||||||.::|..||
Yeast   286 LGKDLSLVSFIVIGMICLVGI------IQGRSWLE----MFQISVSLAVAAIPEGLPIIVTVTLA 340

Human   321 LGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTIT 385
            ||..||||:.||||.||||||||..:|||||||||||:|.|:|.:::.||.:..   .||..::
Yeast   341 LGVLRMAKRKAIVRRLPSVETLGSVNVICSDKTGTLTSNHMTVSKLWCLDSMSN---KLNVLSL- 401

Human   386 GSTYAPIGEVHKDDKPVNCHQYDGLV----ELATICALCNDSALDYNEAKGVYEKVGEATETALT 446
                    :.:|..|..|.:..:.|.    |..||..|||:::  :::...::  :|..|:.||
Yeast   402 --------DKNKKTKNSNGNLKNYLTEDVRETLTIGNLCNNAS--FSQEHAIF--LGNPTDVAL- 453

Human   447 CLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSV--------YCTPNKP 503
                        |:.|:..|..:..|:|     :|...|.|:..||.|:.        .||
Yeast   454 ------------LEQLANFEMPDIRNTV-----QKVQELPFNSKRKLMATKILNPVDNKCT---- 497

Human   504 SRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGS--GSDTLRCLALATH 566
                   ::||||.|.:::..|...  .:|...|..:.:...:.|.|..:  .|:.||....|
Yeast   498 -------VYVKGAFERILEYSTSYL--KSKGKKTEKLTEAQKATINECANSMASEGLRVFGFA-- 551

Human   567 DNPLRREEMHLEDSA-----NFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGD 626
                   ::.|.||:     :.||   :|||.|.:||.||||..|..:::...|.|:.:||||||
Yeast   552 -------KLTLSDSSTPLTEDLIK---DLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITGD 606

Human   627 NKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQ 691
            ::.|||.|.::|||...|..::  ..:|.:.||::.....:...:...|||..|.||..||..|:
Yeast   607 SENTAVNIAKQIGIPVIDPKLS--VLSGDKLDEMSDDQLANVIDHVNIFARATPEHKLNIVRALR 669

Human   692 SFDEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNN 755
            ...::.||||||||||||||.::||::||. ||.|||.||:|||.||:||||:.|:|||:.|:||
Yeast   670 KRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFSTILTAIEEGKGIFNN 734

Human   756 MKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPP 820
            ::.|:.:.:|::|..:..:.|:.|...|..|..:|:||:|::.||.||.:||..|.|.::|.|||
Yeast   735 IQNFLTFQLSTSVAALSLVALSTAFKLPNPLNAMQILWINILMDGPPAQSLGVEPVDHEVMKKPP 799

Human   821 RNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFI---AADGGPRVSFYQLSHFLQCKEDNPDF 882
            |...:.:::..:..|.|.....:...||    :.|:   |.||               |....|
Yeast   800 RKRTDKILTHDVMKRLLTTAACIIVGTV----YIFVKEMAEDG---------------KVTARD- 844

Human   883 EGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLIL 947
                         .||..:..|..:|.|||......:|:..:..:.|.....::.||:......:
Yeast   845 -------------TTMTFTCFVFFDMFNALACRHNTKSIFEIGFFTNKMFNYAVGLSLLGQMCAI 896

Human   948 YVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVAR 988
            |:.....||:...|.::..|::|.||..|.::||..|...|
Yeast   897 YIPFFQSIFKTEKLGISDILLLLLISSSVFIVDELRKLWTR 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A2	NP_733765.1	P-type_ATPase_SERCA	5..988	CDD:319778	317/1014 (31%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:18971376	575..594		8/23 (35%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	787..807		8/19 (42%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250|UniProtKB:O55143	788..1042		51/204 (25%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	931..942		2/10 (20%)
PMR1	NP_011348.1	ATPase-IIA2_Ca	35..940	CDD:130585	318/1016 (31%)