Protein Alignment ATP2A2 and cta3

DIOPT Version :10

• Sequence 1: NP_733765.1
• Gene: ATP2A2 / 488
• HGNCID: 812
• Length: 1042
• Species: Homo sapiens
• Sequence 2: NP_595246.1
• Gene: cta3 / 2541204
• PomBaseID: SPBC839.06
• Length: 1037
• Species: Schizosaccharomyces pombe
• Alignment Length: 1084
• Identity: 329/1084 - (30%)
• Similarity: 501/1084 - (46%)
• Gaps: 190/1084 - (17%)

Human     9 VEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISF 73
            :::|...|..:...||:.|:.:.....:|.|.|.|:.|.:..::::.|..:.:..:|:|||.:||
pombe    15 IKDVESEFLTSIPNGLTHEEAQNRLSEYGENRLEADSGVSAWKVLLRQVLNAMCVVLILAAALSF 79

Human    74 -VLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSV 137
             ...|.|.|           ||..|:|.|..||..||..||..:::|:.....|..|.|..:  .
pombe    80 GTTDWIEGG-----------VISAIIVLNITVGFIQEYKAEKTMDSLRTLASPMAHVTRSSK--T 131

Human   138 QRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQ 202
            ..|.:..:||||:|.:..||.||||:||  :::.....|:::|||||:.|||      |..|..|
pombe   132 DAIDSHLLVPGDVVVLKTGDVVPADLRL--VETVNFETDEALLTGESLPVIK------DAHATFQ 188

Human   203 --------DKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKI------------RDEMVATEQER- 246
                    |:.|:.:|.:.:..|:|.|:..|||:.|:||.|            |.|.......|
pombe   189 MNEDVPIGDRINLAYSSSIVTKGRAKGICYATGMQTQIGAIAAGLRQKGKLFQRPEKDEPNYRRK 253

Human   247 ----------------------TPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWI 289
                                  ||||:||......|..:..::.|.|...:..|..:.|
pombe   254 LNKYYLKVTSYYVQRVLGLNVGTPLQRKLTVLAYILFCIAIILAIIVMAAHSFHVTNEV------ 312

Human   290 RGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTG 354
              :||    |::|.::.|||.|.||::..:|:|.:.|:|:..|||.|.::|.||..:.|||||||
pombe   313 --SIY----AISLGISIIPESLIAVLSITMAMGQKNMSKRRVIVRKLEALEALGGVTDICSDKTG 371

Human   355 TLTTNQMSVCRMFI--LDRVEGDTCSLNEFTI--TGSTYAPIGEVHKDDK-------PVNCHQYD 408
            |:|..:|...|::|  ...:..||...|..||  .....|.:.:|.|:.|       |.| ...|
pombe   372 TITQGKMITRRVWIPSYGYLSVDTSDANNPTIGTVSGLEAAMQDVLKEKKQEMKNIDPSN-QPSD 435

Human   409 GLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNS 473
            ..:.|...|||||.|.::..|. |.:...||.||.||....::.|....:|
pombe   436 QFIPLLKTCALCNLSTVNQTET-GEWVVKGEPTEIALHVFSKRFNYGKEDL-------------- 485

Human   474 VIKQLMKKEFTLE--FSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPM 536
                |....|..|  |..:.|.|:|.....:...|    ::.|||.|.:::||      ||....
pombe   486 ----LKTNTFVREYPFDSEIKRMAVIYEDQQGQYT----VYAKGAVERILERC------STSNGS 536

Human   537 TSGVKQKIMSVIREWGSGSDTLRCLALATH-----DNPLRREEMHLEDSANFIKYETNLTFVGCV 596
            |.....:.:.:.:.....::.||.|||||.     ||    .|....|.|     |::|.||..|
pombe   537 TLEEPDRELIIAQMETLAAEGLRVLALATKVIDKADN----WETLPRDVA-----ESSLEFVSLV 592

Human   597 GMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIF-----GQDEDVTSKAFTGRE 656
            |:.||||.|...:|:||.:|||||.|:|||:..||.||.|.:||.     .:|.:::....||.:
pombe   593 GIYDPPRTESKGAVELCHRAGIRVHMLTGDHPETAKAIAREVGIIPPFISDRDPNMSWMVMTGSQ 657

Human   657 FDELNPSAQRDACLNARC--FARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAM 719
            ||.|  |.:....|.|.|  .||..|..|.|::|.|.......|||||||||:|:||:|.:||||
pombe   658 FDAL--SDEEVDSLKALCLVIARCAPQTKVKMIEALHRRKAFVAMTGDGVNDSPSLKQANVGIAM 720

Human   720 G-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP 783
            | :|:.|||.||::||.|||||:||.|:||||.:::|:.:|:.:|:.||||||  |.|...|.|.
pombe   721 GQNGSDVAKDASDIVLTDDNFSSIVNAIEEGRRMFDNIMRFVLHLLVSNVGEV--ILLVVGLAFR 783

Human   784 E-------ALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGC 841
            :       .:.||::||.|::|...|:..||......|:|.:.|.:.|..:....|....:..|.
pombe   784 DEVHLSVFPMSPVEILWCNMITSSFPSMGLGMELAQPDVMERLPHDNKVGIFQKSLIVDMMVYGF 848

Human   842 YVGAATVGAAAWWFIA-ADGGPRVSFYQLSHF-LQCKEDNPDFEGVDCAIFESPYPMTMALSVLV 904
            ::|  .|....|..|. ..|...:|:...:|: ..|.    |......|:|.   .:|..: :::
pombe   849 FLG--VVSLMTWVVIMYGFGTGNLSYDCNAHYHAGCN----DVFKARSAVFA---VVTFCI-LIM 903

Human   905 TIEMCNALNSLSENQSLLRMPPW-------------ENIWLVGSICLSMSLHFLILYVEPLPLI- 955
            .:|:.|..|||.....:    ||             ||.:|..:|.|:....|..:|:   |:|
pombe   904 AVEVKNFDNSLFNLHGI----PWGEWNFRYFLHTLVENKFLAWAIALAAVSVFPTIYI---PVIN 961

Human   956 ---FQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKE 996
               |:.|.:. .:|.:|....:......|..|.:.|:...|.|:
pombe   962 RDVFKHTYIG-WEWGVVAVAVMFYFFYVEIWKSIRRSLTNPQKK 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A2	NP_733765.1	P-type_ATPase_SERCA	5..988	CDD:319778	326/1074 (30%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:18971376	575..594		5/18 (28%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	787..807		7/19 (37%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250|UniProtKB:O55143	788..1042		52/228 (23%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	931..942		3/10 (30%)
cta3	NP_595246.1	ATPase-IID_K-Na	5..1003	CDD:130586	328/1081 (30%)