Protein Alignment ATP2A2 and sca-1

DIOPT Version :10

• Sequence 1: NP_733765.1
• Gene: ATP2A2 / 488
• HGNCID: 812
• Length: 1042
• Species: Homo sapiens
• Sequence 2: NP_499386.1
• Gene: sca-1 / 176512
• WormBaseID: WBGene00004736
• Length: 1059
• Species: Caenorhabditis elegans
• Alignment Length: 1044
• Identity: 715/1044 - (68%)
• Similarity: 839/1044 - (80%)
• Gaps: 25/1044 - (2%)

Human     1 MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL 65
            ||:||.|...||...||.... ||:.:||:.|:.::|.||:||||||:|.||::|||:||||:||
 Worm     1 MEDAHAKDANEVCKFFGTGPE-GLTPQQVETLRNKYGENEMPAEEGKSLWELILEQFDDLLVKIL 64

Human    66 LLAACISFVLAWFEEGE---ETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMG 127
            ||||.||||||.|||.|   |.:|||||||||||||:|||.||||||||||:||||||||||||.
 Worm    65 LLAAIISFVLALFEEHEDQTEAVTAFVEPFVILLILIANATVGVWQERNAESAIEALKEYEPEMA 129

Human   128 KVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTD 192
            ||.|.....:|.::||::||||:||::||||:|||:||..|.|||:|:|||||||||||||||||
 Worm   130 KVIRSGHHGIQMVRAKELVPGDLVEVSVGDKIPADLRLVKIYSTTIRIDQSILTGESVSVIKHTD 194

Human   193 PVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFG 257
            .|||||||||||||.||||||:|:|||.|:|..||:.|||||||.||..||.|:|||||||||||
 Worm   195 SVPDPRAVNQDKKNCLFSGTNVASGKARGIVFGTGLTTEIGKIRTEMAETENEKTPLQQKLDEFG 259

Human   258 EQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALG 322
            ||||||||:||:|||.|||||||||.|||||::||||||||||||||||||||||||||||||||
 Worm   260 EQLSKVISVICVAVWAINIGHFNDPAHGGSWVKGAIYYFKIAVALAVAAIPEGLPAVITTCLALG 324

Human   323 TRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGS 387
            |||||||||||||||||||||||||||||||||||||||||.:|||..:..||..:..||.|:||
 Worm   325 TRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSKMFIAGQASGDNINFTEFAISGS 389

Human   388 TYAPIGEVHKDDKPVN--CHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE 450
            ||.|:|:|..:.:.:|  ..:::.|.|||.|||:||||::||||.|.:||||||||||||..|.|
 Worm   390 TYEPVGKVSTNGREINPAAGEFESLTELAMICAMCNDSSVDYNETKKIYEKVGEATETALIVLAE 454

Human   451 KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKG 515
            |||||.|...|||..|....||.||:|..||||||||||||||||.||.|  .|..|.:||||||
 Worm   455 KMNVFGTSKAGLSPKELGGVCNRVIQQKWKKEFTLEFSRDRKSMSAYCFP--ASGGSGAKMFVKG 517

Human   516 APEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDS 580
            |||||:.||||:||...|||:||.:.|||:....::|:|.||||||||.|.|.|:....|:||||
 Worm   518 APEGVLGRCTHVRVNGQKVPLTSAMTQKIVDQCVQYGTGRDTLRCLALGTIDTPVSVSNMNLEDS 582

Human   581 ANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDE 645
            ..|:|||.::||||.||||||||.||:.|:|.|..|||||||||||||.||.||.||||:||::|
 Worm   583 TQFVKYEQDITFVGVVGMLDPPRTEVSDSIKACNHAGIRVIMITGDNKNTAEAIGRRIGLFGENE 647

Human   646 DVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPAL 710
            |.|.||:||||||:|.|..|.:||..|:.|||||||||||||:.|||..||||||||||||||||
 Worm   648 DTTGKAYTGREFDDLPPEQQSEACRRAKLFARVEPSHKSKIVDILQSQGEITAMTGDGVNDAPAL 712

Human   711 KKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIF 775
            |||||||:|||||||||:|||||||||||::||:||||||||||||||||||||||||||||.||
 Worm   713 KKAEIGISMGSGTAVAKSASEMVLADDNFASIVSAVEEGRAIYNNMKQFIRYLISSNVGEVVSIF 777

Human   776 LTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIG 840
            :.||||.||||||||||||||||||||||||||||||||||::.||:..:.||||||||||||:|
 Worm   778 MVAALGIPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRHPRSANDGLISGWLFFRYLAVG 842

Human   841 CYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVT 905
            .|||.|||||:.|||:..:.||::::|||:|:::|:.:..:|..:|||:||..:|..||||||||
 Worm   843 TYVGVATVGASMWWFLLYEEGPQITYYQLTHWMRCEIEPDNFADLDCAVFEDNHPNAMALSVLVT 907

Human   906 IEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVL 970
            |||.||:||||||||||.||||:||||:.:|.|||||||:||||:.:..||||||||..:|:.||
 Worm   908 IEMLNAINSLSENQSLLVMPPWKNIWLMAAISLSMSLHFVILYVDIMATIFQITPLNWVEWIAVL 972

Human   971 KISLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVYSTDTN 1035
            ||||||:|:||.|||:||||::...|.|....:|.                 :.|:.||..|...
 Worm   973 KISLPVLLLDEILKFIARNYIDGKPETVGAKARSA-----------------ISLLAWVSVTLAY 1020

Human  1036 FSDM 1039
            |:.|
 Worm  1021 FAWM 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A2	NP_733765.1	P-type_ATPase_SERCA	5..988	CDD:319778	699/987 (71%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:18971376	575..594		11/18 (61%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	787..807		19/19 (100%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250|UniProtKB:O55143	788..1042		148/252 (59%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	931..942		6/10 (60%)
sca-1	NP_499386.1	P-type_ATPase_SERCA	5..990	CDD:319778	699/987 (71%)