DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wek and ZNF354A

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_005640.2	Gene:	ZNF354A / 6940	HGNCID:	11628	Length:	605	Species:	Homo sapiens

Alignment Length:	419	Identity:	114/419 - (27%)
Similarity:	172/419 - (41%)	Gaps:	54/419 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EMTLEEPELGSMLCEECYSVIGQLITFSDSVSKVQAI------FELLRHSEPQDSQDLDALRLEY 100
            ::.||:|.:.....|:.....|.....|.:..|:..|      .||.::..|:.......:....
Human   119 DLKLEKPYIYEGRLEKKQDKKGSFQIVSATHKKIPTIERSHKNTELSQNFSPKSVLIRQQILPRE 183

  Fly   101 GLPPAC-------KQDLEFLD----IDDTEDRCSLVEELTISDHSTSPSPDFEAQTVRTRANLKQ 154
            ..||.|       ||:.:.|:    ..|...:|||.|:..|:..|..     :.:...:...|.:
Human   184 KTPPKCEIQGNSLKQNSQLLNQPKITADKRYKCSLCEKTFINTSSLR-----KHEKNHSGEKLFK 243

  Fly   155 CNSDPKVLASPTASIPEVETKRSRRQQFAAKRNSKVYTATESDDEEAILDEDEAVSPPPLKRKRG 219
            |....|..:..:|.| :.:...:..:.:..|...|.:|.:.|..:.......|         |..
Human   244 CKECSKAFSQSSALI-QHQITHTGEKPYICKECGKAFTLSTSLYKHLRTHTVE---------KSY 298

  Fly   220 RPKGSGK----------QKNVDDSDNVTSREPDDNAKSKQDDKTSELSMSPHGSQ--SSNFVDYP 272
            |.|..||          .:.:...:|.....|        ..|.|..|.|..|.|  .|....|.
Human   299 RCKECGKSFSRRSGLFIHQKIHAEENPCKYNP--------GRKASSCSTSLSGCQRIHSRKKSYL 355

  Fly   273 CKICNETFMSFMALRRHKHDMHGGPKKYVCDHCGKGLKTFTSLVEHQLVHTEEKPCICPVCNAGF 337
            |..|..||.|..:||.|:. :|.|.|.:.|..||:......||::|:.:||.|||..|..|..||
Human   356 CNECGNTFKSSSSLRYHQR-IHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGF 419

  Fly   338 KNKARLRVHSQTH-GEPKFECNVCGKKLQTRAILNKHKYVHTDERRFKCEVCGSGCKNSTALKIH 401
            .:.:||..|...| ||..:.||.|||.|.:.:.|..|:.:||.|:..||:|||...:.|:||..|
Human   420 TSISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQH 484

  Fly   402 LLGHTGLRPYVCKYCGKAFASNTNCRSHK 430
            ...|||.|||.|..|||.|..|::..:|:
Human   485 QRMHTGERPYKCNECGKTFRCNSSLSNHQ 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871	8/43 (19%)
		C2H2 Zn finger	273..294	CDD:275368	8/20 (40%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	14/24 (58%)
		C2H2 Zn finger	413..429	CDD:275368	6/15 (40%)
ZNF354A	NP_005640.2	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..106
		C2H2 Zn finger	189..208	CDD:275368	4/18 (22%)
		COG5048	198..600	CDD:227381	99/340 (29%)
		C2H2 Zn finger	216..236	CDD:275368	6/24 (25%)
		zf-H2C2_2	228..253	CDD:290200	4/29 (14%)
		C2H2 Zn finger	244..264	CDD:275368	4/20 (20%)
		zf-H2C2_2	256..280	CDD:290200	4/24 (17%)
		C2H2 Zn finger	272..292	CDD:275368	4/19 (21%)
		zf-H2C2_2	284..309	CDD:290200	7/33 (21%)
		C2H2 Zn finger	300..320	CDD:275368	3/19 (16%)
		C2H2 Zn finger	356..376	CDD:275368	8/20 (40%)
		zf-H2C2_2	368..393	CDD:290200	9/25 (36%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		zf-H2C2_2	396..421	CDD:290200	12/24 (50%)
		C2H2 Zn finger	412..432	CDD:275368	7/19 (37%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		zf-H2C2_2	453..477	CDD:290200	10/23 (43%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		zf-H2C2_2	480..505	CDD:290200	14/24 (58%)
		C2H2 Zn finger	496..516	CDD:275368	7/18 (39%)
		zf-H2C2_2	508..531	CDD:290200	1/6 (17%)
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	536..561	CDD:290200
		C2H2 Zn finger	552..572	CDD:275368
		zf-H2C2_2	568..589	CDD:290200
		C2H2 Zn finger	580..600	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910