DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wek and ZNF335

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_071378.1	Gene:	ZNF335 / 63925	HGNCID:	15807	Length:	1342	Species:	Homo sapiens

Alignment Length:	639	Identity:	128/639 - (20%)
Similarity:	208/639 - (32%)	Gaps:	249/639 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IISKCFDVE------------MTLEEPELGSMLCEECYSVIGQLITFSDSVSKVQAIFELLRHSE 86
            :|..|..|.            :.|:.|:.|:.:.....|     .|.:.|::.::|:.:     .
Human   145 LIQNCITVTSAEDGGAETTRYLILQGPDDGAPMTSPMSS-----STLAHSLAAIEALAD-----G 199

  Fly    87 PQDSQDLDALRLEYG------LPPAC---KQDLEFLDIDDTEDRCSLVEELTISDHSTSPSPDFE 142
            |..:.  ..|..:.|      ||||.   :.||:.|:        :::|.:.:.        .|:
Human   200 PTSTS--TCLEAQGGPSSPVQLPPASGAEEPDLQSLE--------AMMEVVVVQ--------QFK 246

  Fly   143 AQTVRTRANLKQCNSDPKVLA-------SPTASIPEVETKRSRRQQFAAKRNSKVYTATESDDEE 200
            .:..:.|::.|     ..:|.       .|.|:......|:.|.::::....|:.....|.:|::
Human   247 CKMCQYRSSTK-----ATLLRHMRERHFRPVAAAAAAAGKKGRLRKWSTSTKSQEEEGPEEEDDD 306

  Fly   201 AILD----------------EDE-----------AVSPPPLKRKRGRPKGSGKQKNVDDSDNVTS 238
            .|:|                |||           ..|.|..:|:.|||:...:.:..|..|.|..
Human   307 DIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLEISDLPDGVEG 371

  Fly   239 R------------EPDD-----------------------NAKSKQDDKTSELSMSP-------- 260
            .            ||.|                       .|...|.|..:.....|
Human   372 EPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAENAAPSCPDEHDTLPR 436

  Fly   261 -HGSQSSNFV-----------------DYPCKICNETFMSFMALRRH------------------ 289
             .|..|..|:                 .:.|:||...|:|...||.|
Human   437 RRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCS 501

  Fly   290 ---------KHDM--HGGPKKYVCDHCGKGLKTFTS-----LVEHQLVHTEEK-------PCI-- 329
                     |..|  |.|.|.|.||.|     ::||     ::.|..||:.::       |.:
Human   502 YRSRRWSSLKEHMFNHVGSKPYKCDEC-----SYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSS 561

  Fly   330 --CPVCNAGFKNKARLRVHSQTHG-EPKFECNVCGKKLQTRAILNKHKYVHTD---ERRFKCEVC 388
              ||||...:..:.||..|.:||. |....|:.|||..:.|.....|...|..   .||||||.|
Human   562 FPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFC 626

  Fly   389 GSGCKNSTALKIHLLG-----------------------------HTGLRPYVCKYCGKAFASNT 424
            ...|::..||..|.|.                             |||.:|:.|:||..:.....
Human   627 EFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKK 691

  Fly   425 NCRSH----------KW-KKHPELASKEDETESSRVPVPTLEELRAITREMAKA 467
            |.|.|          :| ::|||      |..|.|.|..:|:::..:.::.:.|
Human   692 NLRLHVRCRHASSFEEWGRRHPE------EPPSRRRPFFSLQQIEELKQQHSAA 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871	10/57 (18%)
		C2H2 Zn finger	273..294	CDD:275368	10/49 (20%)
		C2H2 Zn finger	302..322	CDD:275368	6/24 (25%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	8/48 (17%)
		zf-H2C2_2	397..422	CDD:290200	11/53 (21%)
		C2H2 Zn finger	413..429	CDD:275368	5/15 (33%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..228		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..442		27/167 (16%)
		C2H2 Zn finger	467..487	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..517	CDD:275368	2/19 (11%)
		zf-H2C2_2	509..534	CDD:290200	11/29 (38%)
		C2H2 Zn finger	529..545	CDD:275370	3/15 (20%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		zf-H2C2_2	577..600	CDD:290200	9/22 (41%)
		zf-C2H2	590..612	CDD:278523	6/21 (29%)
		C2H2 Zn finger	592..612	CDD:275368	6/19 (32%)
		C2H2 Zn finger	623..643	CDD:275368	8/19 (42%)
		C2H2 Zn finger	651..672	CDD:275368	0/20 (0%)
		C2H2 Zn finger	680..699	CDD:275368	6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..763		1/8 (13%)
		PRK04654	<795..911	CDD:135173
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1013
		C2H2 Zn finger	1021..1041	CDD:275368
		Involved in the interaction with CCAR2. /evidence=ECO:0000269\|PubMed:19131338	1041..1342
		C2H2 Zn finger	1049..1069	CDD:275368
		zf-H2C2_5	1075..1097	CDD:290620
		C2H2 Zn finger	1077..1097	CDD:275368
		zf-H2C2_2	1089..1114	CDD:290200
		C2H2 Zn finger	1105..1126	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930