DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wek and ZFP64

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_060667.2	Gene:	ZFP64 / 55734	HGNCID:	15940	Length:	681	Species:	Homo sapiens

Alignment Length:	364	Identity:	87/364 - (23%)
Similarity:	146/364 - (40%)	Gaps:	37/364 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 CKQDLEFLD--IDDTEDRCSLVEELTISDHSTSPSPDFEAQTVRTRANLKQCNSDPKVLASPTAS 168
            |||....||  :...:..|.|......:..:.....:......:|:...:...|:.:.:   |.|
Human    36 CKQQFNNLDAFVAHKQSGCQLTGTSAAAPSTVQFVSEETVPATQTQTTTRTITSETQTI---TVS 97

  Fly   169 IPEVETKRSRRQQFAAKRNSKVYTATESDDEEAILDEDEAVSPPPLKRKRGRPKGSGKQKNVDDS 233
            .||          |..:...:.|..|||::     ::...|...|.|.:..:|.....||.::
Human    98 APE----------FVFEHGYQTYLPTESNE-----NQTATVISLPAKSRTKKPTTPPAQKRLN-- 145

  Fly   234 DNVTSREPDDNAKSKQDDKTSELSMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPK 298
                ...|....|:....|..|..:..|....    .:.|::|.:.|.....|:.|.. .|.|.|
Human   146 ----CCYPGCQFKTAYGMKDMERHLKIHTGDK----PHKCEVCGKCFSRKDKLKTHMR-CHTGVK 201

  Fly   299 KYVCDHCGKGLKTFTSLVEHQLVHTEEKPCICPVCNAGFKNKARLRVHSQTH-GEPKFECNVCGK 362
            .|.|..|.......:||.:|..:|::|:|..|.:|....:|.::|.||.::| |:..|:|.:|..
Human   202 PYKCKTCDYAAADSSSLNKHLRIHSDERPFKCQICPYASRNSSQLTVHLRSHTGDAPFQCWLCSA 266

  Fly   363 KLQTRAILNKHKYVHTDERRFKCEVCGSGCKNSTALKIHL-LGHTGLRPYVCKYCGKAFASNTNC 426
            |.:..:.|.:|..||:.|:.||||.|...|.....||.|: :.|:| ..:.|.:|.....|....
Human   267 KFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLKSHIRIKHSG-NNFKCPHCDFLGDSKATL 330

  Fly   427 RSHK---WKKHPELASKEDETESSRVPVPTLEELRAITR 462
            |.|.   ..:|||..|:...:.||:..:...|.:....|
Human   331 RKHSRVHQSEHPEKCSECSYSCSSKAALRIHERIHCTDR 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871
		C2H2 Zn finger	273..294	CDD:275368	5/20 (25%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..405	CDD:275368	7/20 (35%)
		zf-H2C2_2	397..422	CDD:290200	7/25 (28%)
		C2H2 Zn finger	413..429	CDD:275368	4/15 (27%)
ZFP64	NP_060667.2	COG5048	<151..450	CDD:227381	62/225 (28%)
		zf-H2C2_2	161..186	CDD:290200	5/28 (18%)
		C2H2 Zn finger	177..197	CDD:275368	5/20 (25%)
		zf-H2C2_2	190..211	CDD:290200	8/21 (38%)
		C2H2 Zn finger	205..225	CDD:275368	5/19 (26%)
		zf-H2C2_2	217..239	CDD:290200	8/21 (38%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..297	CDD:290200	10/23 (43%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	373..391	CDD:275368
		zf-C2H2_6	425..450	CDD:290623
		C2H2 Zn finger	427..447	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930