DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wek and wdn

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	121/553 - (21%)
Similarity:	190/553 - (34%)	Gaps:	147/553 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GVPTSDWIYWCRLCARDDVVYKVRERDDDLVRIISKCFDVEMTLEEPELGSMLCEECYSVIGQLI 66
            |.||.        .|.|:::       ..|:||.:  ||...::::..|...| ..|.::....:
  Fly    30 GTPTK--------AAHDEIL-------SSLLRINN--FDSISSIKDESLDIDL-SACVTISSASL 76

  Fly    67 TFSDSVSKVQAIFELLRHSEPQDSQDLDALRLEYGLPPACKQDLEFLDIDDTEDRCSLVEELTIS 131
            ...:|:|... .:.:|..|    :|:...|.|.   ...|:.||.      .....::...||..
  Fly    77 VNGNSLSSTD-FWRVLDES----AQNNTELNLS---SDVCRDDLA------ATSSSTVPSTLTSD 127

  Fly   132 DHSTSPSPDFEAQTVRTRANLKQCNSDPKVLASPTASIPEVETKRSRRQQF--------AAKRNS 188
            :||:|   :|....:|........||..|..:|...|.|...:.....||.        ..:|..
  Fly   128 NHSSS---EFSVTFLRPEPPNAFTNSPFKKTSSSGTSTPVKLSPEQLHQQHQLQMPQSQLLQRKP 189

  Fly   189 KVYTAT-------------ESDDEEAILDE--------------------------DEAVSPPPL 214
            |:..||             |....|.::.:                          |.|..|||.
  Fly   190 KLPAATAVRLKVFKEEPPEEKHPPEQVVTKVEVCESELLPPSFTIFQQAKSAESVADAASMPPPA 254

  Fly   215 KRKRGRPKGSGKQKNVD--------DSDNVTSREPDDNAKSKQDDKTSELSMSPHGSQSSNFVDY 271
            ..:.       |...||        |.:.:....||:.||.:.......|:             |
  Fly   255 ASET-------KPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRLT-------------Y 299

  Fly   272 PCKICNETFMSFMALRRH------------------------------KHDMHGGPKKYVCDHCG 306
            .|..|...|.....|::|                              ...:|...|||.||.||
  Fly   300 RCSECQREFELLAGLKKHLKTHRTEGRKDTWKKCPDCGKCLKLGSMWMHRKIHSDNKKYQCDICG 364

  Fly   307 KGLKTFTSLVEHQLVHTEEKPCICPVCNAGFKNKARLRVHSQTHGEPK-FECNVCGKKLQTRAIL 370
            :......:|..|..:|:.|||..||.|...|:.::.|:.|.:.|.:.: :.|..|||..:|...|
  Fly   365 QKFVQKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCL 429

  Fly   371 NKHKYVHTDERRFKCEVCGSGCKNSTALKIHLLGHTGLRPYVCKYCGKAFASNTNCRSHKWKKHP 435
            ..|..||.::|.|.|.||.....:::.||.|...|||:||:.|.||.:.|.:..|     |.||.
  Fly   430 KVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPN-----WLKHT 489

  Fly   436 ELASKEDETESSRVP-VPTLEELRAITREMAKA 467
            ....|.|......:. :|:....::.|.:..||
  Fly   490 RRRHKVDHKTGEHLENIPSYCSKKSTTNKAQKA 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871	12/68 (18%)
		C2H2 Zn finger	273..294	CDD:275368	5/50 (10%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..429	CDD:275368	5/15 (33%)
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	5/19 (26%)
		RPB9	333..425	CDD:224510	25/91 (27%)
		C2H2 Zn finger	333..352	CDD:275368	0/18 (0%)
		zf-H2C2_2	344..369	CDD:290200	8/24 (33%)
		zf-C2H2	358..380	CDD:278523	7/21 (33%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	372..395	CDD:290200	9/22 (41%)
		zf-C2H2	386..408	CDD:278523	6/21 (29%)
		C2H2 Zn finger	388..436	CDD:275368	14/47 (30%)
		zf-H2C2_2	400..425	CDD:290200	7/24 (29%)
		C2H2 Zn finger	416..433	CDD:275368	6/16 (38%)
		zf-H2C2_2	429..453	CDD:290200	9/23 (39%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	457..481	CDD:290200	12/23 (52%)
		C2H2 Zn finger	472..493	CDD:275368	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100