DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wek and CG11695

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	127/586 - (21%)
Similarity:	197/586 - (33%)	Gaps:	195/586 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRLCARDDVVYKVR--ERDD--------DLVRIISKCFDVEMTLEEPELGSMLCEECYSVIGQLI 66
            ||||. ||..:.|.  ::||        :|..:|.|...: :.|....:...||.:|:..:....
  Fly     3 CRLCL-DDAEHSVPIFDQDDSGDQPVPSNLAELIEKHLQL-VLLPNDGVSKSLCTQCWQQLADFE 65

  Fly    67 TFSDSVSKVQAIFELLRHSEPQDSQDLDA-----LRLEYGLPPACKQDLEFLDID---DTEDRCS 123
            .|...|.|.|...:.|:.....:.:|.|.     ...|..:.||...:.|..:||   .:..|.|
  Fly    66 QFCAMVMKKQLGLQQLKMEPFSEDEDADTKAQILCEPEIDVSPAAADNEECNEIDGDASSNSRSS 130

  Fly   124 LVEELTISDHSTSPSPDFEAQTVRTRANLKQCNSDPKVLASPTASIPEVETKRSRRQQFAAKRNS 188
            .:...::.: ...|||      :|.|..|      |:.:.:|            :.|...||..:
  Fly   131 SIRTTSLRE-MRLPSP------IRRRMRL------PRAVTAP------------KTQAVKAKART 170

  Fly   189 KVYTATESDDEEAILDEDEAVSPPPLKRKRGRPKGSGKQKNVDDSDNVTSREPD----------- 242
            |.:.|...:||:|                    :|.|.    .:|.:..|||.|
  Fly   171 KTHKAEADEDEDA--------------------EGEGD----PESRSSNSREMDSYIALHGRLEC 211

  Fly   243 ----------DNAKSKQDDKTSELSMS------------------PHGSQSSNFVDYPCKICNET 279
                      :.|:.|:..:....|:.                  .|.....|:  :.||||::.
  Fly   212 CICGGDEQFPNFAEMKRHFRNHHQSLGYVVCCQRRYKKRALYVDHLHMHNDPNY--FRCKICSKQ 274

  Fly   280 FMSFMALRRHKHDMHGGPKK----YVCDHCGKGLKTFTSLVEHQLVHTEEK-------------- 326
            .:|.::...|....|  |.|    :.||.|.|.......|..|..||.:|:
  Fly   275 LVSRISYDVHMLRFH--PNKDDLSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRSFRTA 337

  Fly   327 ----------------PCICPVCNAGFKNKARLRVHSQT-HGE----PKFECNVCGKKLQTRAIL 370
                            |.||..|.|.||.|..|.||.:| |.|    |:.:|..|...|.....|
  Fly   338 VDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNLLVHKRTVHREGSQLPEVQCQECQVWLSDENSL 402

  Fly   371 NKHKYVHTDE---RRFKCEVCG------------------------SGC----KNSTALKIHLLG 404
            .||.|:|.|.   |::|||.||                        :.|    |:|.:|:.|...
  Fly   403 RKHMYMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRYHHPKEYHKCTHCAKEFKSSRSLEEHTAT 467

  Fly   405 HTGLRPYVCKYCGKAFASNTNCRSHKWKKHPELASKEDETESSRVPVPTLEELRAITREMAKAKQ 469
            |||...|.|.:|.:.|.::.|...|:.:.|             ...|..|::.:.:.....|.|.
  Fly   468 HTGQDLYECAFCERTFKNSGNMHKHRRQMH-------------AAQVAALQQQKKVPPSKRKDKG 519

  Fly   470 D 470
            |
  Fly   520 D 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871	20/77 (26%)
		C2H2 Zn finger	273..294	CDD:275368	6/20 (30%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..405	CDD:275368	9/47 (19%)
		zf-H2C2_2	397..422	CDD:290200	9/24 (38%)
		C2H2 Zn finger	413..429	CDD:275368	4/15 (27%)
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	20/79 (25%)
		C2H2 Zn finger	268..289	CDD:275368	6/20 (30%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..348	CDD:275368	0/20 (0%)
		C2H2 Zn finger	357..376	CDD:275368	9/18 (50%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		C2H2 Zn finger	476..494	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910