DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wek and CG11696

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	134/619 - (21%)
Similarity:	205/619 - (33%)	Gaps:	204/619 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRLCARD-----DVVYKVRERDDDLVRIISKCFDVEMTL---EEPELGSMLCEECYSVIGQLITF 68
            ||||..|     .:..:.........|.:::..:..:.|   |...:.:.||..|:..:.::..|
  Fly     3 CRLCLEDAEHGVPIFGQEPPMGQPAHRQLAELIERHLLLVLAENDVVSTCLCNRCWRQLAEIEQF 67

  Fly    69 SDSVSKVQ-----------AIFELLRHSEPQDSQDLDALRLEYGLPP-------------ACKQD 109
            ...|::.|           .:.||...:||:.:  |.....|..:.|             .|:..
  Fly    68 CSMVAEKQRSLHRSLQLKTELPELPELTEPEPA--LVVWNTESPIEPKLSYEGDDIKDHILCEPV 130

  Fly   110 LEFLDIDDTEDRCSLVEELTISDHSTSPSPDFEAQT------------VRTRAN-------LKQC 155
            ::.|...|.:|          ||:..:..||||.::            |:.|..       |:|.
  Fly   131 IDALSAGDEKD----------SDYGDTFEPDFEPESQPDEEEEPEPDPVKPRPRGRPRKTALQQT 185

  Fly   156 N-----SDPKVLASPTASIPEVETKRSRRQQFAAKRNSKVYTATESDDEEAILDEDE-------- 207
            :     ...|......|.|.|:..:.||.:|...||:|    |...||::.  ||||
  Fly   186 HQIIKRKYEKRKQQNKAKITELSLRESRARQRELKRSS----AGAEDDQDG--DEDEEDEEDVGG 244

  Fly   208 -----AVSPPPLKRKRGRPKGSGKQKNVDDSDNVTSREPDDNAKSKQDD---------------- 251
                 |...|..:.|||||| :.|....||:|: ||..|...:..|:.|
  Fly   245 ELTPDADEQPKPRGKRGRPK-TKKLVTADDNDD-TSEVPVKRSSIKEMDDYIAANVKLDCAICAA 307

  Fly   252 ------------------------------------------------------------KTSEL 256
                                                                        .:..:
  Fly   308 PLEDFNDLKRHFRVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQVM 372

  Fly   257 SMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPKKYVCDHCGKGLKTFTSLVEH-QL 320
            .|....||....| :.|.||...|.....|..|.....|..:..|||.|.|..:|...|..| :.
  Fly   373 HMLRFHSQQQELV-HQCAICEARFAKKFLLTMHLKGHKGTERPEVCDTCSKTFRTKFELSAHVKR 436

  Fly   321 VHTEE-KPCICPVCNAGFKNKAR-------------------------------LRVHSQTH--- 350
            :|..: .|.||.:|...|::||.                               ||.|...|
  Fly   437 MHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHDDR 501

  Fly   351 -GEPKFECNVCGKKLQTRAILNKHKYVHTDERRFKCEVCGSGCKNSTALKIHLLGHTGLRPYVCK 414
             |:.|:.|.:|..:..:||.|:.|...|...:|.||.:|....|...||..|:..|||:..|.|:
  Fly   502 DGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDLYQCQ 566

  Fly   415 YCGKAFASNTNCRSHKWKKHP-ELASKEDETESS 447
            :|.:.|.|:.|..:||.|.|| :...|..:..||
  Fly   567 FCTRTFKSHANMHNHKKKMHPNDWVRKYSQPSSS 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871	14/86 (16%)
		C2H2 Zn finger	273..294	CDD:275368	6/20 (30%)
		C2H2 Zn finger	302..322	CDD:275368	7/20 (35%)
		C2H2 Zn finger	330..350	CDD:275368	8/50 (16%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	10/24 (42%)
		C2H2 Zn finger	413..429	CDD:275368	5/15 (33%)
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	14/74 (19%)
		C2H2 Zn finger	332..349	CDD:275368	0/16 (0%)
		C2H2 Zn finger	357..378	CDD:275368	1/20 (5%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..465	CDD:275368	5/17 (29%)
		C2H2 Zn finger	478..498	CDD:275368	3/19 (16%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..583	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910