DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wek and Zfp64

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001012093.1	Gene:	Zfp64 / 311661	RGDID:	1307948	Length:	678	Species:	Rattus norvegicus

Alignment Length:	369	Identity:	92/369 - (24%)
Similarity:	149/369 - (40%)	Gaps:	47/369 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 CKQDLEFLD--IDDTEDRCSLVEELTISDHSTSPSPDFEAQTVRTRANLKQCNSDPKVLASPTAS 168
            |||....||  :...:..|.|         :|:|.         |..:..|..|:..|.|:||.:
  Rat    36 CKQQFSNLDAFVAHKQSGCQL---------TTTPV---------TAPSTVQFVSEETVPATPTQT 82

  Fly   169 I-----PEVETKRSRRQQFAAKRNSKVYTATESDDEEAILDEDEAVSPPPLKRKRGRPKGSGKQK 228
            .     .|.:|......:|..:...:.|..|||.|     |:...|...|.|.:..:|.....||
  Rat    83 ATTTISSETQTITVAAPEFVFEHGYQTYLPTESTD-----DQTATVIALPTKTRTKKPTAPPAQK 142

  Fly   229 NVDDSDNVTSREPDDNAKSKQDDKTSELSMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDM 293
            .:.      ...|....|:....|..|..:..|....    .:.|::|.:.|.....|:.|.. .
  Rat   143 KLG------CCYPGCQFKTAYGMKDMERHLKIHTGDK----PHKCEVCGKCFSRKDKLKTHMR-C 196

  Fly   294 HGGPKKYVCDHCGKGLKTFTSLVEHQLVHTEEKPCICPVCNAGFKNKARLRVHSQTH-GEPKFEC 357
            |.|.|.|.|..|.......:||.:|..:|::|:|..|.:|....:|.::|.||.::| |:..|:|
  Rat   197 HTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERPFKCQICPYASRNSSQLTVHLRSHTGDAPFQC 261

  Fly   358 NVCGKKLQTRAILNKHKYVHTDERRFKCEVCGSGCKNSTALKIHL-LGHTGLRPYVCKYCGKAFA 421
            .:|..|.:..:.|.:|..||:.|:.|||:.|...|.....||.|: :.|:| ..:.|.:|.....
  Rat   262 WLCSAKFKISSDLKRHMRVHSGEKPFKCDFCNVRCTMKGNLKSHIRIKHSG-NNFKCPHCDFLGD 325

  Fly   422 SNTNCRSHK---WKKHPELASKEDETESSRVPVPTLEELRAITR 462
            |.:..|.|.   ..:|||..::...:.||:..:...|.:....|
  Rat   326 SKSTLRKHSRLHQSEHPEKCAECSYSCSSKAALRVHERIHCTER 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871
		C2H2 Zn finger	273..294	CDD:275368	5/20 (25%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..405	CDD:275368	6/20 (30%)
		zf-H2C2_2	397..422	CDD:290200	7/25 (28%)
		C2H2 Zn finger	413..429	CDD:275368	4/15 (27%)
Zfp64	NP_001012093.1	COG5048	<151..450	CDD:227381	60/225 (27%)
		zf-H2C2_2	161..186	CDD:290200	5/28 (18%)
		C2H2 Zn finger	177..197	CDD:275368	5/20 (25%)
		zf-H2C2_2	190..211	CDD:290200	8/21 (38%)
		C2H2 Zn finger	205..225	CDD:275368	5/19 (26%)
		zf-H2C2_2	217..239	CDD:290200	8/21 (38%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..297	CDD:290200	9/23 (39%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	345..365	CDD:275368	3/19 (16%)
		zf-H2C2_2	357..382	CDD:290200	2/13 (15%)
		C2H2 Zn finger	373..391	CDD:275368
		zf-C2H2_6	424..450	CDD:290623
		C2H2 Zn finger	427..447	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338031
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930