DRSC/TRiP Functional Genomics Resources

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Protein Alignment wek and HIC1

DIOPT Version :10

Sequence 1:NP_524930.1 Gene:wek / 48785 FlyBaseID:FBgn0001990 Length:470 Species:Drosophila melanogaster
Sequence 2:NP_001091672.1 Gene:HIC1 / 3090 HGNCID:4909 Length:733 Species:Homo sapiens


Alignment Length:284 Identity:76/284 - (26%)
Similarity:99/284 - (34%) Gaps:87/284 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 DEAVSP--PPL-----KRKRGRPKGSGKQKNVDDSDNVTSREPDDNAKSKQDDKTSELSMSPHGS 263
            |.||||  |||     .|..|...|.|...:.||            .||..::..|....||.| 
Human   362 DAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDD------------YKSSSEETGSSEDPSPPG- 413

  Fly   264 QSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPKK-----YVCDHCGKGLKTFTSLVEHQLVHT 323
              .:...|||                .|..:|.|:.     |||..||||..:...|..|...|.
Human   414 --GHLEGYPC----------------PHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHV 460

  Fly   324 EE------------------------------------------KPCICPVCNAGFKNKARLRVH 346
            ||                                          :|..|..|:..:|:.|.||.|
Human   461 EEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQH 525

  Fly   347 SQTHGEPK-FECNVCGKKLQTRAILNKHKYVHTDERRFKCEVCGSGCKNSTALKIHLLGHTGLRP 410
            .:||...: :.|.:||||...|..:.:|...|...:.|.|:.||........|..|:..|:|.:|
Human   526 EKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKP 590

  Fly   411 YVCKYCGKAFASNTNCRSHKWKKH 434
            |.|:.||..||...|..|| .|.|
Human   591 YECQVCGGKFAQQRNLISH-MKMH 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wekNP_524930.1 zf-AD 11..80 CDD:462262
SFP1 <226..346 CDD:227516 33/166 (20%)
C2H2 Zn finger 273..294 CDD:275368 2/20 (10%)
C2H2 Zn finger 302..322 CDD:275368 7/19 (37%)
SFP1 <320..401 CDD:227516 26/123 (21%)
C2H2 Zn finger 330..350 CDD:275368 7/19 (37%)
C2H2 Zn finger 357..377 CDD:275368 7/19 (37%)
SFP1 <379..434 CDD:227516 19/54 (35%)
C2H2 Zn finger 385..405 CDD:275368 5/19 (26%)
C2H2 Zn finger 413..429 CDD:275368 6/15 (40%)
HIC1NP_001091672.1 BTB_POZ 26..155 CDD:453885
Mediates HDAC-dependent transcriptional repression 154..315
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..209
PHA03247 <223..325 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..421 21/73 (29%)
Interaction with CTBP1 241..247
COG5048 <501..613 CDD:227381 37/112 (33%)
C2H2 Zn finger 509..529 CDD:275368 7/19 (37%)
zf-C2H2 535..557 CDD:395048 7/21 (33%)
C2H2 Zn finger 537..557 CDD:275368 7/19 (37%)
C2H2 Zn finger 565..585 CDD:275368 5/19 (26%)
zf-H2C2_2 577..602 CDD:463886 10/24 (42%)
C2H2 Zn finger 593..613 CDD:275368 9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

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