DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wek and let-391

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_491744.3	Gene:	let-391 / 182953	WormBaseID:	WBGene00006492	Length:	453	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	64/368 - (17%)
Similarity:	108/368 - (29%)	Gaps:	157/368 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 DDEEAILDEDEAVSPPPLKRKRGRPKGSGKQKNVDDSDNVTSREPDDNAKSKQDDKTSELSMSPH 261
            ::.:||.:|..|...|            ..||..::.:.:. :.||...:.|:
Worm     9 ENSDAIFEEWAAECTP------------DAQKEHEELEEIV-KIPDSTYRKKK------------ 48

  Fly   262 GSQSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPKKYVCDHCGKGLKTFTSLVEH-QLVHTEE 325
            |:|....|. .|::|.........:..|.. .|.|.|.|.||.||......|.::.| ::.|..:
Worm    49 GNQKLPTVT-TCEVCGVALKYPSRIMEHMR-THTGEKPYECDICGMRFTQRTPMINHFRVQHMGD 111

  Fly   326 KPCICPV-CNAGFKNKARLRVHSQTHG-------------------------------------- 351
            .|.:|.. |...|.|.:|...|..:|.
Worm   112 LPFLCNFGCGKRFVNNSRRTAHELSHNGLKRAGPARPYLKPVKKIVCPSMDMDILSNSALANYIS 176

  Fly   352 ----------------------------------------------------------------- 351

Worm   177 PPTIDSIFQSDPSTSSSSPSQFQSSNQTTKQSIYPSEKEMEKAAISNARIDDVINTVLARVLAPI 241

  Fly   352 -------EPK----------------FECNVCGKKLQTRAILNKHKYVHTDERRFKCEVCGSGCK 393
                   ||:                .:||:||..|:..:.:..|...||.|:.|:|..||....
Worm   242 DEEIPIEEPEKAPQKRAYISNRRATLAQCNICGLMLKHPSKIADHIRTHTGEKPFECGECGLSLS 306

  Fly   394 NSTALKIHLLG-HTGLRPYVCKY-CGKAFASNTNCRSHKWKKH 434
            .:::||:|:.. |||.||:.|.: ||.:|.:::..:.|:...|
Worm   307 KASSLKVHIRRMHTGERPFECTWRCGLSFVTDSVRKEHEMTVH 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871
		C2H2 Zn finger	273..294	CDD:275368	3/20 (15%)
		C2H2 Zn finger	302..322	CDD:275368	6/20 (30%)
		C2H2 Zn finger	330..350	CDD:275368	6/20 (30%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	6/20 (30%)
		zf-H2C2_2	397..422	CDD:290200	12/26 (46%)
		C2H2 Zn finger	413..429	CDD:275368	4/16 (25%)
let-391	NP_491744.3	C2H2 Zn finger	59..79	CDD:275368	3/20 (15%)
		zf-H2C2_2	73..96	CDD:290200	9/23 (39%)
		C2H2 Zn finger	87..108	CDD:275368	6/20 (30%)
		C2H2 Zn finger	116..137	CDD:275368	6/20 (30%)
		C2H2 Zn finger	270..290	CDD:275368	6/19 (32%)
		zf-H2C2_2	286..304	CDD:290200	8/17 (47%)
		C2H2 Zn finger	298..319	CDD:275368	6/20 (30%)
		C2H2 Zn finger	327..347	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..377	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000