DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wek and F58G1.2

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001254358.1	Gene:	F58G1.2 / 174931	WormBaseID:	WBGene00010264	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	485	Identity:	89/485 - (18%)
Similarity:	146/485 - (30%)	Gaps:	193/485 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 DIDDTEDRCSLVEELTISDHSTSPSPDFEAQTVRTRANLKQC--NSDPKVLASPTASIPEVETKR 176
            :|.|.||  ||.|:    ||                |..:.|  ..:.:::||..|.    :.::
Worm     5 EIVDRED--SLSED----DH----------------AEHRDCQDEKEQQIIASFNAQ----DAQQ 43

  Fly   177 SRR-QQFAAKRNSKVYTATESDD---------EEAILDEDEAV----SPPPLKRKR------GRP 221
            .|| |:...:...|..|..|::|         .:.:....|.:    :||.:.::|      |||
Worm    44 IRRIQEHFLQECMKKETVAEANDSGRNDVCCPRKKLTGVGELLASLRNPPKIHKERIILGGDGRP 108

  Fly   222 KGSGKQKN-----VDDS---DNVTSREPDDNAKSKQDDKTSELSMSPHGSQSSNFVD-------Y 271
            ....::..     :|.|   |....|:      .:||....:|:|.|..|.|.:.:.       :
Worm   109 IKKLRENRAALNFIDPSAELDKCIVRQ------KQQDFCAPDLNMVPASSLSIDEIRNAVRKSMF 167

  Fly   272 PCKICNETFMSFMALRRHKHDMHGGPKKYV---------CDHCGK-------------------- 307
            .||:|...|.....|.||..|.|  ||.|:         .|:.|:
Worm   168 RCKVCKNRFGEMSLLERHLRDSH--PKAYIAFLENQREMADYMGELERERNRIEELVSGGFIPPE 230

  Fly   308 ---------------------------------GLKTFTSLVEHQLVHTEEKPCICPVCNAGFKN 339
                                             ||......:..:..:.:::...||.|:..|:|
Worm   231 SEIEATSNNLEVDSIPLPGENSQGHIPRLNRYGGLMYPMDALRKKFPYLKKRSPQCPFCDKRFRN 295

  Fly   340 KARLRVH-SQTHGE--------------------PKFECNV------------------------ 359
            ......| ::.|.|                    |..:|::
Worm   296 DISFNNHLTKKHPECAEFVQCLHCFKCLPSAADLPTHDCDLTYLCLDCRPIRNMCNGYRLFRHRT 360

  Fly   360 --------------CGKKLQTRAILNKH-KYVHTDERRFKCEVCGSGCKNSTALKIHLLGHTGLR 409
                          |.:|..|...|.|| |..|...|.|:|..|.....:.||:.||...|||:.
Worm   361 KFHRGYHSGFRCPDCNQKFLTPRKLRKHRKMAHVFSRTFQCHFCEEFFISDTAVTIHERVHTGIL 425

  Fly   410 PYVCKYCGKAFASNTNCRSHKWKKHPELAS 439
            .:.|..|....:.......|..:.|..:.|
Worm   426 KFECTVCDFRASRYLQMEEHTKEHHGYMCS 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871
		C2H2 Zn finger	273..294	CDD:275368	8/20 (40%)
		C2H2 Zn finger	302..322	CDD:275368	4/72 (6%)
		C2H2 Zn finger	330..350	CDD:275368	6/20 (30%)
		C2H2 Zn finger	357..377	CDD:275368	8/58 (14%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	8/24 (33%)
		C2H2 Zn finger	413..429	CDD:275368	2/15 (13%)
F58G1.2	NP_001254358.1	bZIP	<186..222	CDD:304365	7/37 (19%)
		C2H2 Zn finger	372..393	CDD:275368	7/20 (35%)
		C2H2 Zn finger	401..421	CDD:275368	6/19 (32%)
		C2H2 Zn finger	429..449	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000