DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wek and klu-1

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_493611.2	Gene:	klu-1 / 173366	WormBaseID:	WBGene00013970	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	370	Identity:	83/370 - (22%)
Similarity:	137/370 - (37%)	Gaps:	96/370 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SVIGQLITFSDSVSKVQAIFELLR-----HSEPQDSQDLDALRLE---YGLPPACKQDLEFLDID 116
            |.:|......:.:....|.:||.|     .|:.|.:|:.|...|.   ..:|...|:.|.....:
Worm   162 SSLGHSTAHFNQLLAAGAAYELSRERSRSESDMQPTQEDDVRHLNTSTISVPIYAKKPLHKFGGE 226

  Fly   117 DTEDRCSLVEELTISDHSTSPSPDFEAQTVRTRANLKQCNSDPKVLASPTASI---PEVETKRS- 177
                         |...|::|.|     |...|..::|     ::|..|::.:   .::||..|
Worm   227 -------------IKRSSSTPPP-----TSDEREQVEQ-----RLLLRPSSGMEIKKDLETTNSF 268

  Fly   178 ----RRQQFAAKRNSKVY---TATESDDEEAILDEDEAVSPPPLK---RKRGRPKGSGKQKNVDD 232
                .|:|..|.:|:.:|   ||..::|...|      .:|.|||   |.:
Worm   269 VSSWAREQIFAMQNATMYNLLTARSAEDCSTI------STPGPLKVFPRSK-------------- 313

  Fly   233 SDNVTSREPDDNAKSKQDDKTSELSMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDMH--- 294
             |::|....||::::||                   :.|||.:|.:.|.....|.:|....|
Worm   314 -DDMTFAPRDDSSRAKQ-------------------MQYPCTLCGQAFAVHDRLAKHIASRHRQR 358

  Fly   295 -----GGPKKYVCDHCGKGLKTFTSLVEHQLVHTEEKPCICPVCNAGFKNKARLRVHSQTH-GEP 353
                 ...|.:.|:.|.|.......|..|..:||..||..||.||..|.....|..|.:|| ||.
Worm   359 SCTLDDASKVHKCNMCSKSFSRSDMLTRHMRLHTGAKPYSCPTCNQVFSRSDHLSTHLRTHTGEK 423

  Fly   354 KFECNVCGKKLQTRAILNKHKYVH--TDERRFKCEVCGSGCKNST 396
            .:.|.:|......|.::::|...|  ||:......:.....:::|
Worm   424 PYACPMCNYSASRRDMISRHMRTHSLTDDSSISTPISQLSIRSAT 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871	3/19 (16%)
		C2H2 Zn finger	273..294	CDD:275368	5/20 (25%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	4/19 (21%)
		C2H2 Zn finger	385..405	CDD:275368	1/12 (8%)
		zf-H2C2_2	397..422	CDD:290200	83/370 (22%)
		C2H2 Zn finger	413..429	CDD:275368
klu-1	NP_493611.2	C2H2 Zn finger	334..354	CDD:275368	5/19 (26%)
		zf-C2H2	369..391	CDD:278523	5/21 (24%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		zf-H2C2_2	383..408	CDD:290200	11/24 (46%)
		COG5048	395..>448	CDD:227381	17/52 (33%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		zf-H2C2_2	411..436	CDD:290200	8/24 (33%)
		C2H2 Zn finger	427..447	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910