DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wek and LOC101883356

DIOPT Version :9

Sequence 1:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_009290247.2	Gene:	LOC101883356 / 101883356	-ID:	-	Length:	777	Species:	Danio rerio

Alignment Length:	484	Identity:	111/484 - (22%)
Similarity:	179/484 - (36%)	Gaps:	170/484 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPTSDWIYWC--------RL--CARDDVVYKVRERDDDLVRIISKCFDVEMTL---------E 46
            |.:.|::..|.|        ||  |.|....: ..|||.:.:: ..|.|....:|         |
Zfish   186 MRIHTNEKPYACLFCEKRFSRLCDCKRHQKTH-TGERDHECLQ-CGKSFTQSGSLKIHQMIHTGE 248

  Fly    47 EPELGSMLCEECYSVIGQLITFSDSVSKVQAIFELLRHSEPQDSQDLDALRLEYGLPPACKQDLE 111
            :|...| .||:.:|                      |.|..:..:.:......|..|| |::..
Zfish   249 KPHKCS-YCEKSFS----------------------RSSHLKSHERIHTGEKPYCCPP-CQKSF- 288

  Fly   112 FLDIDDTEDRCSLVEELTISDHSTSPSPDFEAQTVRTRANLKQCNSDPKVLASPTASIPEVETKR 176
                   :|.|||...|.:  |:..                           .|.:|.|.::|:|
Zfish   289 -------KDSCSLTYHLLV--HTGE---------------------------KPFSSYPIIKTRR 317

  Fly   177 SRRQQFAAKRNSKVYTATESDDEEAILDEDEAVSPPPLKRKRGRPKGSGKQKNVDDSDNVTSREP 241
            :          ||:                                 ||     |.||.:
Zfish   318 A----------SKL---------------------------------SG-----DHSDQM----- 329

  Fly   242 DDNAKSKQDDKTSELSMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPKKYVCDHCG 306
            ::|.:.:::|:  |.:.:..|:::::.  :.|:.|.::|.....|::|: ..|.|.|.|.|..||
Zfish   330 EENEQRQEEDE--ERNFNTKGTKTTHL--HSCRQCGKSFRRKSKLKKHR-KTHAGEKPYTCTECG 389

  Fly   307 KGL-------------------------KTFTS---LVEHQLVHTEEKPCICPVCNAGFKNKARL 343
            |..                         |:||:   |..||.:||.|||..|..|...|...:.|
Zfish   390 KSFSQLDSYKQHQKTHEDKRDHECLQCGKSFTTAGHLKIHQRIHTGEKPYKCSYCEKSFSQSSDL 454

  Fly   344 RVHSQTH-GEPKFECNVCGKKLQTRAILNKHKYVHTDERRFKCEVCGSGCKNSTALKIHLLGHTG 407
            :.|.:.| ||..:.|..|||..:.::.|..|..|||.|:.|.|..||...::||.||.|:..||.
Zfish   455 KKHERIHTGEKPYHCTQCGKSYKDKSSLTYHLLVHTGEKPFTCTQCGHDFRSSTILKQHMRIHTN 519

  Fly   408 LRPYVCKYCGKAFASNTNCRSHKWKKHPE 436
            .:||.|.:|.|.|:...:|:.|: |.|.:
Zfish   520 EKPYACLFCEKRFSRLDSCKQHQ-KTHTD 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wek	NP_001260472.1	zf-AD	11..80	CDD:214871	17/87 (20%)
		C2H2 Zn finger	273..294	CDD:275368	5/20 (25%)
		C2H2 Zn finger	302..322	CDD:275368	10/47 (21%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	11/24 (46%)
		C2H2 Zn finger	413..429	CDD:275368	5/15 (33%)
LOC101883356	XP_009290247.2	COG5048	26..420	CDD:227381	62/354 (18%)
		C2H2 Zn finger	29..49	CDD:275368
		C2H2 Zn finger	57..77	CDD:275368
		C2H2 Zn finger	85..105	CDD:275368
		C2H2 Zn finger	113..133	CDD:275368
		C2H2 Zn finger	141..161	CDD:275368
		C2H2 Zn finger	169..189	CDD:275368	1/2 (50%)
		C2H2 Zn finger	197..217	CDD:275368	5/19 (26%)
		C2H2 Zn finger	225..245	CDD:275368	3/20 (15%)
		C2H2 Zn finger	253..273	CDD:275368	6/42 (14%)
		C2H2 Zn finger	281..301	CDD:275368	8/30 (27%)
		COG5048	354..737	CDD:227381	63/198 (32%)
		C2H2 Zn finger	357..377	CDD:275368	5/20 (25%)
		C2H2 Zn finger	385..405	CDD:275368	4/19 (21%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	8/19 (42%)
		C2H2 Zn finger	525..545	CDD:275368	7/20 (35%)
		C2H2 Zn finger	553..573	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100