Protein Alignment Mtr4 and NMD5

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_012666.2
• Gene: NMD5 / 853596
• SGDID: S000003893
• Length: 1048
• Species: Saccharomyces cerevisiae
• Alignment Length: 1123
• Identity: 199/1123 - (17%)
• Similarity: 383/1123 - (34%)
• Gaps: 357/1123 - (31%)

  Fly    96 LDIDD-----SATLE---ALRTRIVTHLLDAPK------SCTHEVAAHPDQEYIPLKPFSGVPAK 146
            :||.:     :.||:   |:||...|||.:|.|      :|...:||....|.|.|
Yeast     1 MDITELLQCFACTLDHNAAVRTNAETHLKNASKVPGFLGACLDIIAADEVPENIKL--------- 56

  Fly   147 EYPFVLDPFQRQAILCIDN------------SQSVLVSAHTSAGKTVVAEYAIAKSLAAKQRVIY 199
                       .|.|...|            ..:.|:.:|....:..|.:..:.|::.:   |..
Yeast    57 -----------SASLYFKNKITYGWSAGARQGSNELLDSHVDPDEKPVVKDMLIKTMVS---VSK 107

  Fly   200 TTP--IKALSNQKFREFTDEF--KDVG---------LVTGDVTINPSASCLIMTTEILRNMLYRG 251
            |:|  |:.|.:......::::  |..|         |...|:|:....  |:...||.|...::.
Yeast   108 TSPRCIRVLKSALTVIISEDYPSKKWGNLLPNSLELLANEDITVTYVG--LLCLAEIFRTYRWKN 170

  Fly   252 SEIMREV---------------GWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNA 301
            ::..:::               ..|:|.:..||.:::.|.: .:.:|.:...|.|..|..|:..:
Yeast   171 NDERQDLEELILNYFPALLNYGANVLFQDGKYMNNEQIGEL-VKLIIKIYKFVSYHDLPFTLQRS 234

  Fly   302 RQFAEWVCHLHKQPCHVVYTDYRPTPLQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAG 366
            ..|..|.|..       |....:|.|.:                               |||
Yeast   235 ESFTPWACFF-------VSIIQQPLPQE-------------------------------VLA--- 258

  Fly   367 EAGKGDQKGRHGGIKGTNAGQTNIFKIVKMIMERNFAPVIIF-SFSKKDCEIYAMQMAKLDFNTP 430
             ....:.:.::..:|.......|::::.:.....:......: .|.:..||.:..|..::.|
Yeast   259 -ISDIEVRSKNPWVKCKKWALANLYRLFQRYASTSLTRKFQYDEFKQMYCEEFLTQFLQVVF--- 319

  Fly   431 DEKKLVDEVFNNAMDVLTEEDRRLPQVEN------VLPLLRRGIGIHHGGLL-----PILKETIE 484
                  |::.......|...|..|..:.|      |.....:.:|.|:..:|     |:||.|.|
Yeast   320 ------DQIEKWGTGQLWLSDECLYYILNFVEQCVVQKTTWKLVGPHYNVILQHVIFPLLKPTAE 378

  Fly   485 ILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRA------GRR 543
            .|            |.|.            ..|:::..:...:...|....:|..|      .:|
Yeast   379 TL------------EAFD------------NDPQEYINRNMDFWDVGYSPDLAALALLTTCVTKR 419

  Fly   544 GLDDKGIVILMIDEKVSPAVG--RDIVQGKADPINSAFHLTYNMVLNLL--------RVEEINPE 598
            |.......:..:...:..|||  .:|:...|..|.|...:..:::..|:        .:|:....
Yeast   420 GKTTLQPTLEFMVSTLQSAVGDYNNIMLDNALQIESCLRIFSSIIDRLITKDSPFASEMEKFILT 484

  Fly   599 YMLE--RSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIAS-YHHIRSQLDQHGK------ 654
            |:|.  :|.|.|        |..:|.....:|..:..||....:: |..:.:.|:....
Yeast   485 YVLPFFKSQYGF--------LQSRVCDICSKLGSMDFKDPVITSTIYEGVMNCLNNSSNSLPVEL 541

  Fly   655 -------------QFRQWITKPQYLLPFLQPGRLVKVAAGSQEYD----WGIVLNFKKQDQSRKN 702
                         ||...::  ::::|.:|     |:.:.|.:::    .|::.:|.:|...:..
Yeast   542 TAALALQTFISDDQFNMKLS--EHVVPTMQ-----KLLSLSNDFESDVISGVMQDFVEQFAEQLQ 599

  Fly   703 PLKAEPSVTIDVLLHVSEAAAKTGDTEPCKPNERGCMEVVP-------VAHTLITQISSIRVYFP 760
            |...|...|:  :....:.|....:|....|:....::.:|       .|..:::...||
Yeast   600 PFGVELMNTL--VQQFLKLAIDLHETSNLDPDSFTNVDSIPDESDKQMAALGILSTTISI----- 657

  Fly   761 NDLRSADNRRAVLKTIQEAKKRFPLGPPVL-NPIDDMNIKDREF--------RDIVNT------- 809
              |.|.:|...:||.::::  .:|....:| |.|:|...:..||        |||...
Yeast   658 --LLSFENSPEILKNLEQS--FYPAAEFILKNDIEDFYRECCEFVENSTFLLRDITPISWKILEL 718

  Fly   810 ---------------ISQFEKRLEEHPLHKSPELER-------IHRRYQDKVTLQ-KQLQDLKAE 851
                           :|.|...|....::...||::       |...||..||.: ..|.||:..
Yeast   719 IGECNRKPDSMVSYYLSDFMLALNNILIYGRNELKKNEFYTKIIFEIYQKAVTAEDNSLDDLRVV 783

  Fly   852 LKAARSL-LQMDE---LKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMIFNGVFND 912
            ...::.| |.:|:   .::|:|:|        .||:   |.:   |:..:| |.|.::|:
Yeast   784 FDLSQELVLALDDSLPQQYRERLL--------ADVV---GSI---LTQKNE-LKTNVVFS----- 828

  Fly   913 LTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLDLDADTYVDKFKP 977
                     ::.|        :|..:..::.||.::|.|.::      .| |::...|::..:.|
Yeast   829 ---------VTAF--------NVVISNMITEPLITLQYLKQQ------GC-LEIFFQTWITDYIP 869

  Fly   978 ---FLMDVVLAWCKGSSFLAVCKMTDIFE----------------GSII-RCMRRLEELLRQMCQ 1022
               ...|:.|      |.||:.|:....|                |||: :...||...|||:..
Yeast   870 NYKRCYDIKL------SVLALLKIILKLESNDYSVLNLENLVPQLGSIVTQLASRLPTALRQLAN 928

  Fly  1023 ASKTIGNTDLE--NKFSE 1038
            ..|...::..|  .|:.|
Yeast   929 QRKEFSSSGFEEDTKWDE 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	181/1060 (17%)
NMD5	NP_012666.2	SXM1	2..1048	CDD:227943	199/1122 (18%)