Protein Alignment Mtr4 and MTR4

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_012485.1
• Gene: MTR4 / 853397
• SGDID: S000003586
• Length: 1073
• Species: Saccharomyces cerevisiae
• Alignment Length: 1103
• Identity: 538/1103 - (48%)
• Similarity: 741/1103 - (67%)
• Gaps: 78/1103 - (7%)

  Fly     1 MDIEELFDCFDEVTPSVPPPALNQEEKPSGSSASKKGNKRQADGTTASKEATSSKGAEGDDKGDV 65
            ||..:|||.|:| ||         .|.|:.|:..|..:....|  |.........|.| ::|.:.
Yeast     1 MDSTDLFDVFEE-TP---------VELPTDSNGEKNADTNVGD--TPDHTQDKKHGLE-EEKEEH 52

  Fly    66 TEEPTKRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAPKSCT------- 123
            .|..::..|.:::....:|.|.....|.    :.||...||.|.      :||.|..|
Yeast    53 EENNSENKKIKSNKSKTEDKNKKVVVPV----LADSFEQEASRE------VDASKGLTNSETLQV 107

  Fly   124 -------------HEVAAHPDQEYIPLKPFSGV-PAKEYPFVLDPFQRQAILCIDNSQSVLVSAH 174
                         |:||..|:.:|.|:.....| .|:.|||.|||||..||.|||..:|||||||
Yeast   108 EQDGKVRLSHQVRHQVALPPNYDYTPIAEHKRVNEARTYPFTLDPFQDTAISCIDRGESVLVSAH 172

  Fly   175 TSAGKTVVAEYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIM 239
            ||||||||||||||:||..|||||||:|||||||||:||...||.||||:|||:||||.|.||:|
Yeast   173 TSAGKTVVAEYAIAQSLKNKQRVIYTSPIKALSNQKYRELLAEFGDVGLMTGDITINPDAGCLVM 237

  Fly   240 TTEILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQF 304
            ||||||:|||||||:||||.||:|||:|||||||||||||||:|||||.|||||||||||||.:|
Yeast   238 TTEILRSMLYRGSEVMREVAWVIFDEVHYMRDKERGVVWEETIILLPDKVRYVFLSATIPNAMEF 302

  Fly   305 AEWVCHLHKQPCHVVYTDYRPTPLQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLAN----- 364
            |||:|.:|.||||:|||::||||||||:|||.||||:|:||||..|:|:||..|||.::|
Yeast   303 AEWICKIHSQPCHIVYTNFRPTPLQHYLFPAHGDGIYLVVDEKSTFREENFQKAMASISNQIGDD 367

  Fly   365 ---AGEAGKGDQKGRHGGIKGTNAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLD 426
               ....||..|..:.|..||...|  :|:||||||.::.:.|||:|||||:|||..|::|:|||
Yeast   368 PNSTDSRGKKGQTYKGGSAKGDAKG--DIYKIVKMIWKKKYNPVIVFSFSKRDCEELALKMSKLD 430

  Fly   427 FNTPDEKKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGL 491
            ||:.|||:.:.::||||:.:|.|.||.|||::::||||||||||||.||||||||.|||||.||.
Yeast   431 FNSDDEKEALTKIFNNAIALLPETDRELPQIKHILPLLRRGIGIHHSGLLPILKEVIEILFQEGF 495

  Fly   492 IKALFATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMID 556
            :|.|||||||::||||||:||:||:.||:||::|||:|.||||||:||||||||||:||||:|||
Yeast   496 LKVLFATETFSIGLNMPAKTVVFTSVRKWDGQQFRWVSGGEYIQMSGRAGRRGLDDRGIVIMMID 560

  Fly   557 EKVSPAVGRDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQV 621
            ||:.|.|.:.:|:|:||.::|||||.|||:|||:|||.|:||:|||.||:||||..::|    .:
Yeast   561 EKMEPQVAKGMVKGQADRLDSAFHLGYNMILNLMRVEGISPEFMLEHSFFQFQNVISVP----VM 621

  Fly   622 EQKTLELNK----LTIKDEHNIASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAA-G 681
            |:|..||.|    :.::||.|:..||.|...:..:.:..||.:|.|...|.||||||||:::. |
Yeast   622 EKKLAELKKDFDGIEVEDEENVKEYHEIEQAIKGYREDVRQVVTHPANALSFLQPGRLVEISVNG 686

  Fly   682 SQEYDWGIVLNFKKQDQSRKNPLKA---EPSVTIDVLLHVSEAAAKTGDTEPCKP---------- 733
            ...|.||.|::|.|: .:::||...   ..|..::|:::.....:.....:|..|
Yeast   687 KDNYGWGAVVDFAKR-INKRNPSAVYTDHESYIVNVVVNTMYIDSPVNLLKPFNPTLPEGIRPAE 750

  Fly   734 -NERGCMEVVPVAHTLITQISSIRVYFPNDLRSADNRRAVLKTIQEAKKRFPLGPPVLNPIDDMN 797
             .|:....|:|:....|..|.::|:|.|.|:|::..:..|.|:::|..:|||.|.|||:|:.:|.
Yeast   751 EGEKSICAVIPITLDSIKSIGNLRLYMPKDIRASGQKETVGKSLREVNRRFPDGIPVLDPVKNMK 815

  Fly   798 IKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQLQDLKAELKAARSLLQMD 862
            |:|.:|..::..|.....:|..:||..|..||.::.:|..|..|.:.::.||.::..:::::|:|
Yeast   816 IEDEDFLKLMKKIDVLNTKLSSNPLTNSMRLEELYGKYSRKHDLHEDMKQLKRKISESQAVIQLD 880

  Fly   863 ELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVC 927
            :|:.|||||||:|:|.|.|:||.|||||||:||.||||:||:||||.||:|...||.||||||..
Yeast   881 DLRRRKRVLRRLGFCTPNDIIELKGRVACEISSGDELLLTELIFNGNFNELKPEQAAALLSCFAF 945

  Fly   928 DEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLDLDADTYVDKFKPFLMDVVLAWCKGSSF 992
            .|:..|:.:...||:.||::|:::|.:|||:..:.|:::....||:.|:..||:||..||:|::|
Yeast   946 QERCKEAPRLKPELAEPLKAMREIAAKIAKIMKDSKIEVVEKDYVESFRHELMEVVYEWCRGATF 1010

  Fly   993 LAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNTDLENKFSEGIRLLKRDIVFAASLYL 1055
            ..:|||||::|||:||..:|||||::::...:.||||:.|:.|....::|:.||||.|.||||
Yeast  1011 TQICKMTDVYEGSLIRMFKRLEELVKELVDVANTIGNSSLKEKMEAVLKLIHRDIVSAGSLYL 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	492/929 (53%)
MTR4	NP_012485.1	Dob10	143..1068	CDD:443638	494/931 (53%)