DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and SKI2

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_013502.3	Gene:	SKI2 / 851114	SGDID:	S000004390	Length:	1287	Species:	Saccharomyces cerevisiae

Alignment Length:	1153	Identity:	389/1153 - (33%)
Similarity:	590/1153 - (51%)	Gaps:	153/1153 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DIEELFDCFDEVTPSVPPPALNQEEKPSGSSASKKGNKRQADGTTASKEATSSKGAEGDDKGDVT 66
            |.:.|||.         |..:|:..||..|.|..:....|      .||.....  |.|::.|:.
Yeast   189 DGQGLFDI---------PEGMNRGIKPMDSPAENEDQNGQ------FKELKQLN--EIDNELDIR 236

  Fly    67 EEPTK-RLKQE---ASTVAVDDDNNADDEPTRTLDIDDSATLEAL--------RTRIVTHLLDAP 119
            .|..: :||:|   |.:::.:....|.:|  .|.|..|.|.::.|        ||:.|:..:...
Yeast   237 IEANEAKLKEEEKSAKSISEEIMEEATEE--TTADNADDAEIDELLPIGIDFGRTKPVSKSVPVK 299

  Fly   120 KSCTHEV-AAHPDQEYIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVA 183
            |...|.| ..|..:.:..|.|   .||:.:||.||.||::|:..::...||.|:|||||||||||
Yeast   300 KEWAHVVDLNHKIENFDELIP---NPARSWPFELDTFQKEAVYHLEQGDSVFVAAHTSAGKTVVA 361

  Fly   184 EYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDV--GLVTGDVTINPSASCLIMTTEILRN 246
            |||||.:.....:.|||:|||||||||||:|.:.|.||  ||:||||.|||.|:||||||||||:
Yeast   362 EYAIAMAHRNMTKTIYTSPIKALSNQKFRDFKETFDDVNIGLITGDVQINPDANCLIMTTEILRS 426

  Fly   247 MLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHL 311
            |||||::::|:|.:|:|||:||:.|::|||||||.:|:||.:|:::.||||:||..:||.|:...
Yeast   427 MLYRGADLIRDVEFVIFDEVHYVNDQDRGVVWEEVIIMLPQHVKFILLSATVPNTYEFANWIGRT 491

  Fly   312 HKQPCHVVYTDYRPTPLQHYIF------PAGGDGIHLIVDEKGQFKEDNFTTAMAVL-------- 362
            .::..:|:.|..||.||:..|:      |        ::::..:|.|.||.....:|
Yeast   492 KQKNIYVISTPKRPVPLEINIWAKKELIP--------VINQNSEFLEANFRKHKEILNGESAKGA 548

  Fly   363 ------------ANAGEAGKGDQKGR------------HGGIKGTNAGQTNIFK----------- 392
                        |..|..|...:.||            .||.:|..|..:|..|
Yeast   549 PSKTDNGRGGSTARGGRGGSNTRDGRGGRGNSTRGGANRGGSRGAGAIGSNKRKFFTQDGPSKKT 613

  Fly   393 ---IVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEEDRRL 454
               ||..:.:|...|:::|.||||.||.||..:..::|....||..:......::..|.:|||.|
Yeast   614 WPEIVNYLRKRELLPMVVFVFSKKRCEEYADWLEGINFCNNKEKSQIHMFIEKSITRLKKEDRDL 678

  Fly   455 PQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTAPRK 519
            ||:.....||.|||.:||||||||:||.|||||.:|.||.||||||||||||:|.|||:|::.||
Yeast   679 PQILKTRSLLERGIAVHHGGLLPIVKELIEILFSKGFIKVLFATETFAMGLNLPTRTVIFSSIRK 743

  Fly   520 FDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILM-IDEKVSPAVGRDIVQGKADPINSAFHLTY 583
            .||...|.::.||:.||||||||||||..|.||:| .:..:|.|..:::..|....:.|.|.|||
Yeast   744 HDGNGLRELTPGEFTQMAGRAGRRGLDSTGTVIVMAYNSPLSIATFKEVTMGVPTRLQSQFRLTY 808

  Fly   584 NMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQV-----EQKTLELNKLTIKDEHNIASYH 643
            ||:|||||:|.:..|.|::.||.:...:...|....|:     |.:|:|.....|.| ::|..:.
Yeast   809 NMILNLLRIEALRVEEMIKYSFSENAKETLQPEHEKQIKVLQEELQTIEYKSCEICD-NDIEKFL 872

  Fly   644 HIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQD-----QSRKNP 703
            .:.....:......|.:.|...:|..|:.||||.....:.....|.|.....:|     .:...|
Yeast   873 ELMLAYKEATVNLMQEMVKSPSILHILKEGRLVAFRDPNDCLKLGFVFKVSLKDAVCVIMTFTKP 937

  Fly   704 LKAEPSVTIDVLLHVSEAAAKTGDTEPCKPNERGCMEVVPVAHTLITQISSIRVYFP-------- 760
            .|. |:...:.|::..:|........|........||.|||  |.|..|:..:...|
Yeast   938 YKL-PNGEPNHLIYFPKADGYRRRNFPKFQKTDFYMEEVPV--TAIEVITKRKFAAPLGKVIKKD 999

  Fly   761 ----NDLRSADNRRAVLKTIQEA----KKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRL 817
                |:..:..|.....||::||    |:...:...:|   |..||:|..|:  :.:|
Yeast  1000 VAALNEFNAETNNILDGKTLKEAINIEKQGLKIHQILL---DRTNIRDEIFK--LKSI------- 1052

  Fly   818 EEHPLHKSPEL-ERIHRRYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGD 881
                  |.|.| :.|..:::..| ::|::::| ..|.:.::|..:.:.:.|..||:...:.....
Yeast  1053 ------KCPNLSQHIVPKFKAHV-IKKKIEEL-YHLMSDQNLSLLPDYEKRLAVLKDTEFIDQNH 1109

  Fly   882 VIEFKGRVACELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKS--ATELSGP 944
            .:..|||||||::|..||::||:|.:.........:.|||||.||.:.|:.|....  ...|:..
Yeast  1110 NVLLKGRVACEINSGYELVLTELILDNFLGSFEPEEIVALLSVFVYEGKTREEEPPIVTPRLAKG 1174

  Fly   945 LRSMQDLARRIAKVSTECKLDLDAD--TYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSII 1007
            .:.::::.:::..|....::.|..|  .::|:.:..:|:||..|.:|.||..:.:|:...||:::
Yeast  1175 KQRIEEIYKKMLCVFNTHQIPLTQDEAEFLDRKRFAMMNVVYEWARGLSFKEIMEMSPEAEGTVV 1239

  Fly  1008 RCMRRLEELLRQMCQASKTIGNTDLENKFSEGIRLLKRDIVFAASLYL 1055
            |.:..|:|:.|::..||..|||:.|..|.|....|:||||||||||||
Yeast  1240 RVITWLDEICREVKTASIIIGNSTLHMKMSRAQELIKRDIVFAASLYL 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	365/1058 (34%)
		DEAD	154..299	CDD:278688	89/146 (61%)
		HELICc	390..554	CDD:238034	86/177 (49%)
		rRNA_proc-arch	600..853	CDD:289976	58/279 (21%)
		DSHCT	881..1048	CDD:285374	53/170 (31%)
SKI2	NP_013502.3	Dob10	137..1287	CDD:226947	387/1151 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I2625
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S388
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.660