DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and HEN2

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_565338.1	Gene:	HEN2 / 815269	AraportID:	AT2G06990	Length:	995	Species:	Arabidopsis thaliana

Alignment Length:	1021	Identity:	497/1021 - (48%)
Similarity:	691/1021 - (67%)	Gaps:	63/1021 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EEPT---KRLKQEASTVAVDDDNNADDEPT-------RTLDIDDSATLEALRTRIVTHLLDAPKS 121
            |||.   ||.:.|:|.:      .:|:.||       |:|                      .::
plant     6 EEPETLGKRKESESSKL------RSDETPTPEPRTKRRSL----------------------KRA 42

  Fly   122 CTHEVAAHPDQEYIPLKP-----------FSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHT 175
            |.||||...|  |.|.|.           |:|..||.|||.|||||..::.|::..:|:||||||
plant    43 CVHEVAVPND--YTPTKEETIHGTLDNPVFNGDMAKTYPFKLDPFQSVSVACLERKESILVSAHT 105

  Fly   176 SAGKTVVAEYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMT 240
            |||||.|||||||.:...|||||||:|:|||||||:||...|||||||:|||||::|:||||:||
plant   106 SAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHEFKDVGLMTGDVTLSPNASCLVMT 170

  Fly   241 TEILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFA 305
            |||||.|||||||:::||.||:|||||||:|:||||||||::|.||..::.||||||:.||.:||
plant   171 TEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIKMVFLSATMSNATEFA 235

  Fly   306 EWVCHLHKQPCHVVYTDYRPTPLQHYIFPAGGDGIHLIVDEKGQFKEDNFT----TAMAVLANAG 366
            ||:|:||||||||||||:||||||||.||.||.|::|:||:..||:||:|.    |.....:|.|
plant   236 EWICYLHKQPCHVVYTDFRPTPLQHYAFPMGGGGLYLVVDDNEQFREDSFVKMQDTFPKPKSNDG 300

  Fly   367 EAGKGDQKGRHGGIKGTNAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPD 431
            :.....:.|..|...|...|.::::|||||||||.|.||||||||:::||.:|:.|:||||||.:
plant   301 KKSANGKSGGRGAKGGGGPGDSDVYKIVKMIMERKFEPVIIFSFSRRECEQHALSMSKLDFNTDE 365

  Fly   432 EKKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALF 496
            ||::|::||||||..|.||||.||.:|.:||||:|||.:||.||||::||.:|:||.|||:||||
plant   366 EKEVVEQVFNNAMQCLNEEDRSLPAIELMLPLLQRGIAVHHSGLLPVIKELVELLFQEGLVKALF 430

  Fly   497 ATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSP 561
            |||||||||||||:||:|||.:|:||...|:|.|||||||:|||||||.|::||.|:||||::..
plant   431 ATETFAMGLNMPAKTVVFTAVKKWDGDSHRYIGSGEYIQMSGRAGRRGKDERGICIIMIDEQMEM 495

  Fly   562 AVGRDIVQGKADPINSAFHLTYNMVLNLL-RVE-EINPEYMLERSFYQFQNQAALPGLHDQVEQK 624
            ...||::.||..|:.|.|.|:|..:|||| |.| :...|:::..||:|||::.|||.:.::|.:.
plant   496 NTLRDMMLGKPAPLLSTFRLSYYTILNLLSRAEGQFTAEHVIRHSFHQFQHEKALPDIGNKVSKL 560

  Fly   625 TLELNKLTIKDEHNIASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGI 689
            ..|...|....|..:|.||:::..:.:|.|:....|.:|:.:|.||..|||||:..|..::.||:
plant   561 EEEAAILNASGEAEVAEYHNLQFDIAKHEKKLMSEIIRPERVLCFLDTGRLVKIREGGTDWGWGV 625

  Fly   690 VLNFKKQDQSRKNPLKAE-PSVTIDVLLHVSEAAAKTG-DTEPCKP--NERGCMEVVPVAHTLIT 750
            |:|..|..........:. ....:|.|||.|...::.| ..:||.|  .|:|.|.||||...||:
plant   626 VVNVVKNSSVGTGSASSHGGGYIVDTLLHCSTGFSENGAKPKPCPPRAGEKGEMHVVPVQLPLIS 690

  Fly   751 QISSIRVYFPNDLRSADNRRAVLKTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEK 815
            .:|.:|:..|:|||..:.|:::|..:||...|||||.|.|:|:.||||:|.|..|:|:.|.:.|:
plant   691 ALSRLRISVPSDLRPVEARQSILLALQELSSRFPLGFPKLHPVKDMNIQDTEIVDLVSQIEEVEQ 755

  Fly   816 RLEEHPLHKSPELERIHRRYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPG 880
            :|..||:|||.:.::| :.:|.|..:..::|.||::::.::.....||||:|.|||:::|:....
plant   756 KLLAHPMHKSEDDQQI-KSFQRKAEVNYEIQQLKSKMRDSQLQKFRDELKNRSRVLKKLGHIDAD 819

  Fly   881 DVIEFKGRVACELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPL 945
            .|::.|||.||.:.:.||||:||::|||.||||...|..||.|||:..:||:|.|....||:.||
plant   820 GVVQVKGRAACLIDTGDELLVTELMFNGTFNDLDHHQVAALASCFIPVDKSNEQVNLRNELTKPL 884

  Fly   946 RSMQDLARRIAKVSTECKLDLDADTYVDK-FKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRC 1009
            :.:||.||:||::..||||::|.:.||:. .:||||||:.:|.||:||..:.:|||||||||||.
plant   885 QQLQDSARKIAEIQHECKLEIDVEEYVESTIRPFLMDVIYSWSKGASFAEIIQMTDIFEGSIIRS 949

  Fly  1010 MRRLEELLRQMCQASKTIGNTDLENKFSEGIRLLKRDIVFAASLYL 1055
            .|||:|.|.|:..|::.:|.:.||:||:.....|:|.|:||.||||
plant   950 ARRLDEFLNQLRAAAEAVGESSLESKFAAASESLRRGIMFANSLYL 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	487/992 (49%)
		DEAD	154..299	CDD:278688	100/144 (69%)
		HELICc	390..554	CDD:238034	111/163 (68%)
		rRNA_proc-arch	600..853	CDD:289976	91/256 (36%)
		DSHCT	881..1048	CDD:285374	82/167 (49%)
HEN2	NP_565338.1	Dob10	34..995	CDD:226947	485/985 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I1094
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	961	1.000	Inparanoid score	I49
OMA	1	1.010	-	-		QHG53687
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2451
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840