DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and Mtrex

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_082427.1	Gene:	Mtrex / 72198	MGIID:	1919448	Length:	1040	Species:	Mus musculus

Alignment Length:	1065	Identity:	665/1065 - (62%)
Similarity:	819/1065 - (76%)	Gaps:	44/1065 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EELFDCFDEVTPSVPPPALNQEEK----PSGSSASKKGNKRQADGTTASKEATSSKGAEGDDKGD 64
            :|||..|::.:.|......::|::    |.| ||.|.|.:..   |....|:.|.    |.:|.|
Mouse     7 DELFSVFEDDSTSAAGAKKDKEKEKWKGPPG-SADKAGKRLD---TKLQSESASG----GKNKRD 63

  Fly    65 VTEEPTKRLKQEASTVAVDDDNNADDEP-----TRTLD-IDDSATLEALRTRIVTHLLDAPKSCT 123
            :..|.|                   |||     .|..| |::..:|..|..|:....::..:.||
Mouse    64 LDVEGT-------------------DEPIFGKKPRIEDSINEDLSLADLMPRVKVQSVETVEGCT 109

  Fly   124 HEVAAHPDQEYIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIA 188
            ||||...|::||||||..|..||||||:||.|||:||.|:||:|||||||||||||||.||||||
Mouse   110 HEVALPADEDYIPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIA 174

  Fly   189 KSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSE 253
            .:|..|||||:|:|||||||||:||..:||:||||:||||||||:||||:|||||||:|||||||
Mouse   175 LALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSE 239

  Fly   254 IMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHV 318
            :||||.||:|||||||||.|||||||||:|||||||.|||||||||||||||||:||||||||||
Mouse   240 VMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHV 304

  Fly   319 VYTDYRPTPLQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHGGIKGT 383
            :||||||||||||||||||||:||:|||.|.|:||||.|||.||.:||:..|||||||.||.|
Mouse   305 IYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTK-- 367

  Fly   384 NAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLT 448
              |.:|:||||||||||||.|||||||||||||.||:||.||||||.:|||:|:||||||:|.|:
Mouse   368 --GPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFNNAIDCLS 430

  Fly   449 EEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVL 513
            :||::|||||:|||||:||||||||||||||||||||||.||||||||||||||||:||||||||
Mouse   431 DEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVL 495

  Fly   514 FTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADPINSA 578
            ||..||:|||.||||||||||||:|||||||:||:||||||:|||:||.:|:.:::|.|||:|||
Mouse   496 FTNARKYDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSA 560

  Fly   579 FHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYH 643
            ||||||||||||||||||||||||:||||||:..|:||:.::|:....:.||:.|.:|.|:..|:
Mouse   561 FHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEENVVIYY 625

  Fly   644 HIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPLKAEP 708
            .||.||.:.||:..::|.||:|.||||||||||||.....::.||:|:||.|:...:.|..:.:|
Mouse   626 KIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDP 690

  Fly   709 SVTIDVLLHVSEAAAKTGDTE---PCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSADNRR 770
            ...::|||..|:.:.|...||   |.||:|:|.|:||||...|::.||::|:|.|.|||..|||:
Mouse   691 LYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISTVRLYIPKDLRPVDNRQ 755

  Fly   771 AVLKTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRY 835
            :|||:|||.::|||.|.|:|:|||||.|:|:..:.::..:..||.|:..||||..|.||.::...
Mouse   756 SVLKSIQEVQRRFPDGVPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLC 820

  Fly   836 QDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELL 900
            :.|..:...::..|.|||.||::|||||||.|||||||:|:....||||.|||||||:|||||||
Mouse   821 ERKAQIALDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELL 885

  Fly   901 MTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLD 965
            :|||:|||:||||::.||.|||||||..|.|||..|...:|:||||.||:.|:||||||.|.||:
Mouse   886 LTEMMFNGLFNDLSSEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLE 950

  Fly   966 LDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNT 1030
            :|.:||:..|||.|||||..|..|::|..:|||||:||||||||||||||||||||||:|.||||
Mouse   951 IDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNT 1015

  Fly  1031 DLENKFSEGIRLLKRDIVFAASLYL 1055
            :|||||:|||..:||||||||||||
Mouse  1016 ELENKFAEGITKIKRDIVFAASLYL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	642/972 (66%)
		DEAD	154..299	CDD:278688	117/144 (81%)
		HELICc	390..554	CDD:238034	137/163 (84%)
		rRNA_proc-arch	600..853	CDD:289976	110/255 (43%)
		DSHCT	881..1048	CDD:285374	116/166 (70%)
Mtrex	NP_082427.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..77		19/87 (22%)
		Dob10	92..1040	CDD:226947	636/951 (67%)
		DEAD	142..285	CDD:278688	116/142 (82%)
		DEIH box	250..253		2/2 (100%)
		HELICc	372..536	CDD:238034	137/163 (84%)
		rRNA_proc-arch	582..838	CDD:289976	110/255 (43%)
		DSHCT	866..1033	CDD:285374	116/166 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849251
Domainoid	1	1.000	248	1.000	Domainoid score	I2140
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6257
Inparanoid	1	1.050	1326	1.000	Inparanoid score	I147
Isobase	1	0.950	-	0	Normalized mean entropy	S388
OMA	1	1.010	-	-		QHG53687
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	1	1.000	-	-		oto94290
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R764
SonicParanoid	1	1.000	-	-		X2451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740