DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and SKIV2L

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_008860.4	Gene:	SKIV2L / 6499	HGNCID:	10898	Length:	1246	Species:	Homo sapiens

Alignment Length:	1052	Identity:	375/1052 - (35%)
Similarity:	553/1052 - (52%)	Gaps:	112/1052 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DDDNNADDEP-----------------TRTLDIDDSATLEALRTRIVTHLLDAPKSCTHEVAAHP 130
            :|:|.|..:|                 .|...::|....|| .|.:.|.  :||:..:.|..|.|
Human   225 EDENEAVGQPGGPRGDTVSASPCSAPLARASSLEDLVLKEA-STAVSTP--EAPEPPSQEQWAIP 286

  Fly   131 DQEYIPLKPFSGV---PAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLA 192
            .....|:..|..:   ||.::.|..|.||:||||.::...||.|:||||||||||||||||.:..
Human   287 VDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQK 351

  Fly   193 AKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMRE 257
            ...|.|||:|||||||||||:|.:.|.||||:||||.::|.||||||||||||:|||.||:::|:
Human   352 HMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRD 416

  Fly   258 VGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTD 322
            :.||:|||:||:.|.||||||||.||:|||:|..:.||||:|||.:||:|:..|.::..:|:.|.
Human   417 LEWVIFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTV 481

  Fly   323 YRPTPLQHYIFPAGGD----GIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHG---GI 380
            .||.||:||:|.....    .:.|::|.:|.|....:..|:       || |.::..:|.   |.
Human   482 TRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAV-------EA-KKERMSKHAQTFGA 538

  Fly   381 K-----GTNAGQTNIF-KIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEV 439
            |     |..|....:: .::..:..|...||::|:||:..|:..|..:..||..|..||..:...
Human   539 KQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLF 603

  Fly   440 FNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMG 504
            ....:..|...||:||||.::..||.||:|:||.|:||||||.:|:||..||:|.||||||||||
Human   604 LQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMG 668

  Fly   505 LNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVG--RDI 567
            :|||||||:|.:.||.||..||.:..|||:||||||||||||..|.|||:...:| |.:.  ..:
Human   669 VNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRV-PEMADLHRM 732

  Fly   568 VQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQV--EQKTLELNK 630
            :.||...:.|.|.|||.|:||||||:.:..|.|::|||.:|      |...|..  ||...||.|
Human   733 MMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEF------PSRKDSKAHEQALAELTK 791

  Fly   631 -LTIKDEH-------NIASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDW 687
             |...:|.       ::..|:....:|.:.....::.|.:....|..|..||:|.|.........
Human   792 RLGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLSAGRVVVVKNQEHHNAL 856

  Fly   688 GIVLNFK------------------KQDQSRKNPLKAE---PSVTIDVLLHVSEAAAKTGDTEPC 731
            |::|...                  .||...:.|..||   |...:...|.:.|.        ||
Human   857 GVILQVSSNSTSRVFTTLVLCDKPLSQDPQDRGPATAEVPYPDDLVGFKLFLPEG--------PC 913

  Fly   732 KPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSADNRR-----------AVLKTIQE---AKKR 782
               :...:::.|.....|| ...:||.....|.....|:           ||...:||   ..:.
Human   914 ---DHTVVKLQPGDMAAIT-TKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVTTAVQELLRLAQA 974

  Fly   783 FPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQLQD 847
            .|.|||.|:|::|:.:||....:......:.|:.::......||.....:.:.::::.:||:::.
Human   975 HPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPAQYLKLRERMQIQKEMER 1039

  Fly   848 LKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMIFNGVFND 912
            |:. |.:.:|||.:.|...|..|||.:||......::..|||||.:|| .|||:||::|:...:.
Human  1040 LRF-LLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSS-HELLLTELMFDNALST 1102

  Fly   913 LTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLDLDADTYVDKFKP 977
            |...:..||||..||........:....|...:..::.:|:||.:|...|.|:...:.:|.:...
Human  1103 LRPEEIAALLSGLVCQSPGDAGDQLPNTLKQGIERVRAVAKRIGEVQVACGLNQTVEEFVGELNF 1167

  Fly   978 FLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNTDLENKFSEGIRL 1042
            .|::||..|.:|..|..:..::...||.::||::||.|:.|.:..|::.:|...|..|......|
Human  1168 GLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATL 1232

  Fly  1043 LKRDIVFAASLY 1054
            |:||||||||||
Human  1233 LRRDIVFAASLY 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	372/1044 (36%)
		DEAD	154..299	CDD:278688	95/144 (66%)
		HELICc	390..554	CDD:238034	82/164 (50%)
		rRNA_proc-arch	600..853	CDD:289976	61/297 (21%)
		DSHCT	881..1048	CDD:285374	50/166 (30%)
SKIV2L	NP_008860.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..246		4/20 (20%)
		Dob10	280..1244	CDD:333050	361/992 (36%)
		DEVH box	423..426		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720