Protein Alignment Mtr4 and Brr2

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_648818.3
• Gene: Brr2 / 39737
• FlyBaseID: FBgn0263599
• Length: 2142
• Species: Drosophila melanogaster
• Alignment Length: 1070
• Identity: 226/1070 - (21%)
• Similarity: 392/1070 - (36%)
• Gaps: 323/1070 - (30%)

  Fly     7 FDCFDEVTPSVPPPALNQE---------------------EKPSGSSASKKGNKRQADGTTASKE 50
            :||||    .:....||::                     ||..|:||..|..::...|.:..:|
  Fly   317 YDCFD----FIKQLKLNRQMVLYCTMLASAQTDSERQRIREKMRGNSALAKILRQLDTGKSEDQE 377

  Fly    51 ATSSKGAEGDDKGDVTEEPTKRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHL 115
            ...::|:: ..|||..:.......|.|..             .:.|::::.|..:.      :|.
  Fly   378 EGEARGSK-RGKGDAEDGGAAAAGQVAGV-------------RQLLELEEMAFTQG------SHF 422

  Fly   116 LDAPKSCT------------HEVAAHPDQEYIP------LKPFSGVPAKEYPFVLDPFQ------ 156
            : |.|.|.            :|....|..:.:|      |:|...:|....| |.:.|:
  Fly   423 M-ANKRCQLPDGSYRKQRKGYEEVHVPALKPVPFDANEELQPVDKLPKYVQP-VFEGFKTLNRIQ 485

  Fly   157 -RQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSL-----------AAKQRVIYTTPIKALSNQ 209
             |.....:|:.:::|:.|.|.||||.||...:.:.:           |...::||..|:|:|..:
  Fly   486 SRLYKAALDSDENMLLCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQE 550

  Fly   210 KFREFTDEFK----DVGLVTGDVTIN----PSASCLIMTTEILRNMLYRGSE--IMREVGWVVFD 264
            ....|.....    .|..:|||..:.    .:...::.|.|....:..:|.|  .:..|..|:.|
  Fly   551 MVGNFGRRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRLVIID 615

  Fly   265 EIHYMRDKERGVVWE-------ETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCH-VVYT 321
            |||.:.| |||.|.|       ..:....:.||.|.||||:||.:..|.:   |..:|.. :.|.
  Fly   616 EIHLLHD-ERGPVLEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATF---LRVKPDKGLFYF 676

  Fly   322 D--YRPTPL-QHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHGGIKGT 383
            |  |||..| |.||.          |.||...|.......:........||:..
  Fly   677 DNSYRPVSLEQQYIG----------VTEKKALKRFQVMNEIVYEKTMEHAGRNQ----------- 720

  Fly   384 NAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLT 448
                                 |::|..|:|:....|..:..:..........:.| .:.:|:||.
  Fly   721 ---------------------VLVFVHSRKETGKTARAVRDMCLEQDTLGSFLKE-GSASMEVLR 763

  Fly   449 EEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVL 513
            .|..::...| :..||..|..|||.|:..:.:..:|.||.:..|:.|.:|.|.|.|:|:||.||:
  Fly   764 TEAEQVKNTE-LKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVI 827

  Fly   514 FTAPRKFDGKKFRWI--SSGEYIQMAGRAGRRGLDDKGIVILMID-------------------- 556
            ....:.::.:|.||:  |:.:.:||.|||||...|.||..||:.:
  Fly   828 IKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQFYLSLLNQQLPIESQ 892

  Fly   557 --EKVSPAVGRDIVQGKADPINSAFH---LTYNMVLNLLR--------VEEINPEYMLERSFYQF 608
              .|:...:..:||.|....:..|.:   .|| :.:.:||        .:.|..:.:||
  Fly   893 FISKLPDMLNAEIVLGTVQHLQDAVNWLGYTY-LYIRMLRNPTLYGVSHDAIKADPLLE------ 950

  Fly   609 QNQAALPGLHD-----------QVEQKTLELNKLTIKDEHNIASYHHIRSQLDQHGKQFRQWITK 662
            |::|.|  ||.           :.::||   ....:.|...|||::::..:         ..:|.
  Fly   951 QHRADL--LHTAACCLERSGLIKYDRKT---GHFQVTDLGRIASHYYLTHE---------TMLTY 1001

  Fly   663 PQYLLPFLQPGRLVKVAAGSQEYDWGIV-----LNFKKQDQSRKNPLK---AEPSVTIDVLL--H 717
            .|.|...|....|.:|.:.|.|:....|     |..:|..:....|:|   .|.|..::|||  :
  Fly  1002 NQLLKQTLSEIELFRVFSLSSEFRHISVREEEKLELQKLMERVPIPIKESIEEHSAKVNVLLQAY 1066

  Fly   718 VS----EAAAKTGD----TEPCKPNERGCMEVV------PVAHTLIT-----------QISSIRV 757
            :|    |..|...|    |:......|...|:|      .:|...:|           .::.:|.
  Fly  1067 ISQLKLEGFALMSDMVFITQSAARLMRAIFEIVLTRGWAQLADKTLTLCKMIDRRMWQSMTPLRQ 1131

  Fly   758 Y--FPNDLRSADNRRAVLKTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIV------NTISQFE 814
            :  .|::         :.|.::  ||.||.|..       .:::..|..:::      .||.:|
  Fly  1132 FKKMPDE---------IAKKLE--KKHFPWGRL-------YDLEPHELGELIRVPKLGKTIHKF- 1177

  Fly   815 KRLEEHPLHKSPELE-------------RIHR------RYQDKVTLQKQ-----LQDLKAELKAA 855
                   :|:.|:||             |:..      ::.:||..|.:     ::|:.:||
  Fly  1178 -------VHQFPKLELSTHIQPITRGTLRVELTITPDFQWDEKVHGQSEGFWVLIEDVDSEL--- 1232

  Fly   856 RSLLQMDELKHRKRVLRRMGYCKPGDVIEF 885
                    :.|.:..|.:..|.:....::|
  Fly  1233 --------ILHHEFFLLKQKYSQDEHQLKF 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	194/893 (22%)
Brr2	NP_648818.3	Helicase_PWI	259..368	CDD:436309	12/54 (22%)
		DEXHc_Brr2_1	464..677	CDD:350777	55/217 (25%)
		BRR2	476..1020	CDD:440817	143/612 (23%)
		Sec63	982..1285	CDD:460740	59/319 (18%)
		BRR2	1309..1848	CDD:440817
		DEXHc_Brr2_2	1325..1514	CDD:350779
		Sec63	1811..2127	CDD:460740